Person: MUMCU, GONCA
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MUMCU
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GONCA
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Publication Metadata only Salivary levels of antimicrobial peptides Hnp 1-3, Ll-37 and S100 in Behcet's disease(PERGAMON-ELSEVIER SCIENCE LTD, 2012) MUMCU, GONCA; Mumcu, Gonca; Cimilli, Hale; Karacayli, Umit; Inanc, Nevsun; Ture-Ozdemir, Filiz; Eksioglu-Demiralp, Emel; Ergun, Tulin; Direskeneli, HanerBackground: Oral ulcer is the cardinal clinical sign and increased neutrophilic activity is a part of the pathogenesis in Behcet's disease (BD). Saliva, as a part of the innate immune response, contains antimicrobial peptides (AMPs) that are derived from both oral epithelial cells and neutrophils. The aim of this study was to investigate the associations between salivary levels of AMPs HNP 1-3, LL-37 and S100 and disease course in patients with Behcet's disease (BD). Methods: Fifty-three patients with BD and 44 healthy controls (HC) were included in the study. Disease severity score reflecting organ involvement was calculated. Salivary HNP 1-3, LL-37 and S100 levels were measured in unstimulated saliva samples by ELISA. Results: Salivary HNP 1-3 and S100 levels in BD patients (2715.2 +/- 1333.4 mu g/ml and 430.6 +/- 203.9 mu g/ml) were significantly higher compared to HC (1780.6 +/- 933.2 mu g/ml and 365.3 +/- 84.7 mu g/ml) (p = 0.000 and p = 0.004, respectively). Although LL-37 levels were also higher in BD than HC (190.9 +/- 189.1 vs 143.1 +/- 128.9 ng/ml), no significant difference was observed (p = 0.53). Salivary HNP 1-3 and LL-37 levels were associated with the severity of BD (mild disease: 1975.1 +/- 1174.2 mu g/ml and 115.9 +/- 109.4 ng/ml vs severe disease: 2955.7 +/- 1305.6 mu g/ml and 215.3 +/- 203.8 ng/ml, p = 0.020 and p = 0.031, respectively). Salivary LL-37 levels also correlated with the number of monthly oral ulcers (r = 0.5 p = 0.000). Conclusion: An increase in salivary HNP 1-3 and S100 levels might be associated with enhanced local and systemic innate responses in BD. (C) 2011 Elsevier Ltd. All rights reserved.Publication Metadata only A composite index for determining the impact of oral ulcer activity in Behcet's disease and recurrent aphthous stomatitis(WILEY-BLACKWELL PUBLISHING, INC, 2009) MUMCU, GONCA; Mumcu, G.; Sur, H.; Inanc, N.; Karacayli, U.; Cimilli, H.; Sisman, N.; Ergun, T.; Direskeneli, H.Background: Although number, frequency and healing time of oral ulcers and pain are generally used for clinical practice and studies in Behcet's disease (BD) and recurrent aphthous stomatitis (RAS), no standardized activity index is currently present to monitor clinical manifestations associated with oral ulcers. The aim of this study was to develop a standardized composite index (CI) to assess oral ulcer activity in BD and RAS. Methods: In this cross-sectional study, 121 patients with BD and 45 patients with RAS were included. Sixty-five percentage of BD and 68.9% of RAS patients were in active stage during the previous 3 months. The developed CI included the presence of oral ulcers, ulcer-related pain and functional status and was evaluated in patients with both active and inactive disease for content validity. Results: Composite index score was observed to be higher in active patients with RAS (6.94 +/- 2.19) compared with active BD patients (6.01 +/- 2.04) (P = 0.04). The number of oral ulcers and healing time of oral ulcers were significantly higher in RAS compared with BD (P = 0.018, P = 0.001 respectively). CI score correlated with the number of oral ulcers in both BD and RAS (P = 0.000, P = 0.002 respectively). CI score was '0' for inactive patients without oral ulcer in BD and RAS. Conclusions: The presented CI as an oral ulcer activity index seems to be a reliable and suitable tool for evaluating the clinical impact and disease-specific problems in BD and RAS.