Person: MUMCU, GONCA
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MUMCU
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GONCA
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Publication Metadata only Accuracy of the Dentaport ZX apex locator for working length determination when retreating molar root canals(WILEY-BLACKWELL, 2014) MUMCU, GONCA; Cimilli, Hale; Aydemir, Seda; Arican, Burcin; Mumcu, Gonca; Chandler, Nicholas; Kartal, NevinThe aim of this study was to evaluate the accuracy of the Dentaport ZX apex locator for working length determination during root canal retreatment of mandibular molars. Fifteen extracted mandibular first molars with separate mesial canals and apical foraminae and one distal canal were selected. The mesiobuccal and distal canals were investigated; the length with the file tip at the major diameter was defined as the tooth length (TL). The canals were prepared with ProTaper files to 1mm short of this and filled with gutta-percha and AH Plus sealer. One week later, the root fillings were removed using ProTaper retreatment files. Tooth length was remeasured and recorded as the retreatment tooth length (RTL). Then electronic measurements were taken at the major (electronic apex locator (EAL) major) and minor (EAL minor) foraminae as suggested by the instrument display. These lengths were compared with RTL and measurements 0.5 and 1mm short of this distance. For both canals, no significant difference was found between RTL and EAL major, and 0.5mm short of RTL and EAL minor (P>0.05). There were significant differences found between all other readings. The Dentaport ZX could not detect the minor foramen accurately but was able to indicate the major foramen in molars undergoing a root canal retreatment procedure.Publication Metadata only Spiral computed tomographic demonstration of C-shaped canals in mandibular second molars(BRITISH INST RADIOLOGY, 2005) MUMCU, GONCA; Cimilli, H; Cimilli, T; Mumcu, G; Kartal, N; Wesselink, PObjectives: The aim of this study was to evaluate the prevalence of C-shaped canals in single rooted mandibular second molars with spiral computed tomographic imaging in detail. Methods: One hundred and twelve single-rooted mandibular second molar samples were selected from 491 extracted mandibular second molars. The teeth were scanned by spiral computed tomographic technique to examine canal configurations. Results: The evaluation criteria of the shape of roots was based on Manning's category as round, oval and C-shaped. The prevalence of C-shaped canals was found to be 8. 1 % in mandibular second molars. The evaluation of the root canal configurations of C-shaped mandibular second molars with single roots (40 teeth) was based on Vertucci's classification. Vertucci type 1 canals were most frequently seen in C-shaped mandibular second molars (40%). Additionally, we disclosed three additional canal types. Conclusion: Results of this study demonstrated that high resolution visualization of the root canal shape can be achieved by spiral computed tomographic imaging.Publication Metadata only Salivary and Serum B-cell Activating Factor (BAFF) Levels after Hydroxychloroquine Treatment in Primary Sjogren's Syndrome(QUINTESSENCE PUBLISHING CO INC, 2013) MUMCU, GONCA; Mumcu, Gonca; Bicakcigil, Muge; Yilmaz, Neslihan; Ozay, Hale; Karacayli, Umit; Cimilli, Hale; Yavuz, SulePurpose: Some evidence implicates a role of hydroxychloroquine (HQ) in the management of Sjogren's syndrome. This study evaluated the effect of HQ on saliva B-cell activating factor (BAFF) levels as well as health related quality of life (QoL) in patients with primary Sjogren's syndrome (pSS). Materials and Methods: Ten pSS patients who had been treated with HQ for at least 2 years and 15 healthy controls (HC) were included in the study. First, HQ was withdrawn for 12 weeks, then baseline evaluation was performed. Subsequently, HQ was restarted and further evaluations were carried out after 12 and 24 weeks of HQ treatment. Oral infection foci were eliminated by dental and periodontal treatments in both groups before enrollment. BAFF levels were evaluated with ELISA in serum and unstimulated mixed saliva. Salivary flow rates of patients and the control group were measured as well. Oral health quality of life (QoL) was evaluated by an oral health impact profile-14 (OHIP-14) questionnaire. Results: Salivary BAFF levels (median: 12.39 ng/ml) were significantly decreased by using HQ both at 12 (2.78 ng/ml, P = 0.008) and 24 weeks (0.54 ng/ml, P = 0.011). Similarly, decreases in serum BAFF levels (5.23 ng/ml) were seen at 12 and 24 weeks after HQ treatment (2.18 ng/ml, P = 0.008 and 0.0 ng/ml, P = 0.012, respectively). Serum and salivary BAFF levels were significantly lower in healthy controls (0.37 ng/ml and 0.0 ng/ml, resp.) compared to those of pSS before HQ therapy (P = 0.006 and P = 0.001, resp.). Unstimulated salivary flows were similar in patients treated with HQ after 12 (0.38 ml/min) and 24 weeks (0.50 ml/min) (P = 0.51) but higher than the patients' rate at baseline (0.04 ml/min) (P = 0.008). Conclusion: Salivary and serum BAFF levels were lowered in patients with pSS when treated with HQ. In addition, decreased disease activity and increased salivary flows can be achieved with HQ in pSS patients.Publication Metadata only Salivary levels of antimicrobial peptides Hnp 1-3, Ll-37 and S100 in Behcet's disease(PERGAMON-ELSEVIER SCIENCE LTD, 2012) MUMCU, GONCA; Mumcu, Gonca; Cimilli, Hale; Karacayli, Umit; Inanc, Nevsun; Ture-Ozdemir, Filiz; Eksioglu-Demiralp, Emel; Ergun, Tulin; Direskeneli, HanerBackground: Oral ulcer is the cardinal clinical sign and increased neutrophilic activity is a part of the pathogenesis in Behcet's disease (BD). Saliva, as a part of the innate immune response, contains antimicrobial peptides (AMPs) that are derived from both oral epithelial cells and neutrophils. The aim of this study was to investigate the associations between salivary levels of AMPs HNP 1-3, LL-37 and S100 and disease course in patients with Behcet's disease (BD). Methods: Fifty-three patients with BD and 44 healthy controls (HC) were included in the study. Disease severity score reflecting organ involvement was calculated. Salivary HNP 1-3, LL-37 and S100 levels were measured in unstimulated saliva samples by ELISA. Results: Salivary HNP 1-3 and S100 levels in BD patients (2715.2 +/- 1333.4 mu g/ml and 430.6 +/- 203.9 mu g/ml) were significantly higher compared to HC (1780.6 +/- 933.2 mu g/ml and 365.3 +/- 84.7 mu g/ml) (p = 0.000 and p = 0.004, respectively). Although LL-37 levels were also higher in BD than HC (190.9 +/- 189.1 vs 143.1 +/- 128.9 ng/ml), no significant difference was observed (p = 0.53). Salivary HNP 1-3 and LL-37 levels were associated with the severity of BD (mild disease: 1975.1 +/- 1174.2 mu g/ml and 115.9 +/- 109.4 ng/ml vs severe disease: 2955.7 +/- 1305.6 mu g/ml and 215.3 +/- 203.8 ng/ml, p = 0.020 and p = 0.031, respectively). Salivary LL-37 levels also correlated with the number of monthly oral ulcers (r = 0.5 p = 0.000). Conclusion: An increase in salivary HNP 1-3 and S100 levels might be associated with enhanced local and systemic innate responses in BD. (C) 2011 Elsevier Ltd. All rights reserved.Publication Open Access Comparison of the oral health-related quality of life and dental pain in symptomatic irreversible pulpitis and pericoronitis(ELSEVIER TAIWAN, 2012-09) MUMCU, GONCA; Cimilli, Hale; Karacayli, Umit; Sisman, Nur; Kartal, Nevin; Mumcu, GoncaBackground/purpose: The oral health-related quality of life (OHRQoL) reveals important information about a patient's perceptions in clinical practice, and pain is a critical point when evaluating OHRQoL in clinical practice. The aim of the study was to compare pain patterns by means of the Dental Pain-Screening Questionnaire (DePaQ) and an OHRQoL evaluation between symptomatic irreversible pulpitis and pericoronitis. Materials and methods: In this cross-sectional study, 50 patients with symptomatic irreversible pulpitis (with a female:male ratio of 22:28 and a mean age of 35.6 +/- 11.8 years) and 38 patients with pericoronitis (with a female:male ratio of 21:17 and a mean age of 26.3 +/- 9.08 years) were selected. In addition to a visual analogue scale (VAS, 0-100 mm), dental pain was evaluated by means of a Dental Pain Questionnaire (DePaQ). The Oral Health Impact Profile-14 (OHIP-14) was used to examine the OHRQoL status. Results: Scores of the OHIP-14 and VAS were significantly higher in patients with irreversible pulpitis (29.9 +/- 11.8 and 91.80 +/- 10.03, respectively) compared to those suffering from pericoronitis (18.6 +/- 8.7 and 51.05 +/- 36.67, respectively; P < 0.001). According to the DePaQ, the presence of continuous pain, pain radiating to the surrounding area, pain when chewing or eating on the side of the mouth with the affected teeth, pain experienced as an electric shock, and difficulty sleeping were related to a poor OHIP-14 score in symptomatic irreversible pulpitis (33.5 +/- 10.57, 30.82 +/- 11.4, 30.30 +/- 11.55, 33.92 +/- 10.28, and 27.53 +/- 11.77, respectively) compared with those with pericoronitis (20.09 +/- 11.27, 20.37 +/- 7.85, 19.64 +/- 7.87, 20.56 +/- 9.69, and 19.88 +/- 7.9, respectively; P = 0.003, <0.001, <0.001, <0.001, and 0.005, respectively). VAS scores significantly differed between groups according to all DePaQ items (P < 0.05). Conclusion: The DePaQ gives detailed information about clinical conditions related to pain and the OHRQoL status in both symptomatic irreversible pulpitis and pericoronitis. VAS scores differed between the groups according to the DePaQ items. Copyright (c) 2012, Association for Dental Sciences of the Republic of China. Published by Elsevier Taiwan LLC. All rights reserved.Publication Metadata only Prevalence and distribution of oral lesions: a cross-sectional study in Turkey(BLACKWELL MUNKSGAARD, 2005) MUMCU, GONCA; Mumcu, G; Cimilli, H; Sur, H; Hayran, O; Atalay, TOBJECTIVES: The purpose of this study was to evaluate the prevalence and distribution of oral lesions (OLs) in Turkish population. SUBJECTS AND METHODS: In this cross-sectional study, 765 residents (F/M: 375/390) were selected by the cluster sampling method and examined according to WHO criteria. RESULTS: Excessive melanin pigmentation (6.9%) was the most common lesion in the study population. The tongue lesions observed in this study were as follows: fissured tongue (5.2%), varices (4.1%), hairy tongue (3.8%), geographic tongue (1.0%), atrophic tongue papillae (0.7%) and ankyloglossia (0.3%). The denture-related lesions were denture stomatitis (4.3%), suction irritation (0.8%), denture hyperplasia and torus palatinus as bony lesion (0.5%) and traumatic ulcers (0.3%). In regression analysis, being 65 years old and over was found as a statistically significant risk factor for the occurrence of pigmentation, fissured tongue, varices, hairy tongue, denture stomatitis and petechiae (P < 0.05). CONCLUSIONS: Pigmentation, fissured tongue and denture stomatitis were observed to be the most common lesions in Turkish population. Elderly population was a significant risk factor for occurrence of some OLs.Publication Metadata only Salivary levels of HNP 1-3 are related to oral ulcer activity in Behcet's disease(WILEY, 2013) MUMCU, GONCA; Mumcu, Gonca; Cimilli, Hale; Karacayli, Umit; Inanc, Nevsun; Ture-Ozdemir, Filiz; Eksioglu-Demiralp, Emel; Ergun, Tulin; Direskeneli, HanerBackground Saliva contains antimicrobial peptides derived from oral epithelium as well as neutrophils in the innate immune response. The aim of this study was to examine the association between salivary human neutrophil peptide (HNP) 1-3 levels originating from neutrophils and oral ulcers in patients with Behcet's disease (BD). Methods Ninety-five patients with BD (F/M: 39/56; mean age: 38.711.9years) and 53 healthy controls (HC; F/M: 23/30; mean age: 35.210.1years) were included in the study. The disease control group (F/M: 20/33; mean age: 33.7 +/- 10.7years) was comprised of patients with oral infection regarding endodontic infection (n=32) and pericoronitis (n=21). Salivary HNP 1-3 levels of groups were measured in unstimulated samples by ELISA (Hycult, the Netherlands). Results A statistically significant increase was found in salivary HNP 1-3 levels of patients with BD (2268.28 +/- 1216.38g/ml) compared with HC (1836.49 +/- 857.76g/ml), patients with endodontic infection (849.9 +/- 376.1g/ml), and patients with pericoronitis (824.3 +/- 284.02g/ml; P=0.024, 0.000 and 0.000, respectively). The ratio of active oral ulcer (100%, n=14) was higher in low HNP 1-3 levels (1000g/ml) than the others (66.7%, n=54) in active patients with BD (P=0.008). Moreover, salivary HNP 1-3 levels were significantly lower in patients with endodontic infection and patients with pericoronitis compared with those in the HC group and patients with BD (P=0.000). Conclusion A decrease in salivary HNP 1-3 levels might be a biological factor for predisposition to oral ulcers in patients with BD and oral infection in healthy patients.Publication Metadata only A composite index for determining the impact of oral ulcer activity in Behcet's disease and recurrent aphthous stomatitis(WILEY-BLACKWELL PUBLISHING, INC, 2009) MUMCU, GONCA; Mumcu, G.; Sur, H.; Inanc, N.; Karacayli, U.; Cimilli, H.; Sisman, N.; Ergun, T.; Direskeneli, H.Background: Although number, frequency and healing time of oral ulcers and pain are generally used for clinical practice and studies in Behcet's disease (BD) and recurrent aphthous stomatitis (RAS), no standardized activity index is currently present to monitor clinical manifestations associated with oral ulcers. The aim of this study was to develop a standardized composite index (CI) to assess oral ulcer activity in BD and RAS. Methods: In this cross-sectional study, 121 patients with BD and 45 patients with RAS were included. Sixty-five percentage of BD and 68.9% of RAS patients were in active stage during the previous 3 months. The developed CI included the presence of oral ulcers, ulcer-related pain and functional status and was evaluated in patients with both active and inactive disease for content validity. Results: Composite index score was observed to be higher in active patients with RAS (6.94 +/- 2.19) compared with active BD patients (6.01 +/- 2.04) (P = 0.04). The number of oral ulcers and healing time of oral ulcers were significantly higher in RAS compared with BD (P = 0.018, P = 0.001 respectively). CI score correlated with the number of oral ulcers in both BD and RAS (P = 0.000, P = 0.002 respectively). CI score was '0' for inactive patients without oral ulcer in BD and RAS. Conclusions: The presented CI as an oral ulcer activity index seems to be a reliable and suitable tool for evaluating the clinical impact and disease-specific problems in BD and RAS.Publication Metadata only Crack Formation on Resected Root Surfaces Subjected to Conventional, Ultrasonic, and Laser Root-End Cavity Preparation(MARY ANN LIEBERT, INC, 2014) MUMCU, GONCA; Aydemir, Seda; Cimilli, Hale; Mumcu, Gonca; Chandler, Nicholas; Kartal, NevinObjective: The aim of this study was to evaluate cracks on root ends following resection and cavity preparation with a laser and two established techniques. Background data: If root canal treatment of a tooth fails, an apicoectomy operation may be indicated. Three millimeters of the root tip is resected and a cavity of similar depth with parallel walls is cut to receive a root-end filling. Materials and methods: Sixty extracted human maxillary anterior teeth were used. Their root canals were prepared with rotary instruments, and they were filled with gutta-percha. Twenty teeth were resected with tungsten carbide fissure burs, and their root-end cavities cut with tungsten carbide round burs at a slow speed (Group 1). The other 40 teeth were resected with an Er:YAG laser, and root-end cavities were made with the same laser (Group 2), or with an ultrasonically-powered zirconium nitride coated retrotip (Group 3). The number and types of cracks on the resected surfaces were assessed using a stereomicroscope before and after cavity preparation. Results: Cracking was not significantly different between the more conventional group and the laser groups after resections (p > 0.05) or following cavity preparation (p > 0.05). Conclusions: In this in vitro study, the laser resection and root-end preparation technique did not influence the number or type of cracks formed on the root surfaces.Publication Metadata only The correlation between root canal patterns and interorificial distance in mandibular first molars(2006) MUMCU, GONCA; Cimilli H., Mumcu G., Cimilli T., Kartal N., Wesselink P.Objectives: The aim of this study was to investigate the relationship of the distance between mesiobuccal (MB) and mesiolingual (ML) orifices (interorificial distances) in the pulp chamber floor and the degree of canal curvature in the mandibular first molars. Study design: In this in vitro study, 102 extracted teeth were radiographed in both buccolingual (CV) and mesiodistal (PV) directions and then grouped according to the Vertucci classification. The interorificial distance was measured by the stereomicroscope method. Results: The interorificial distance was significantly higher in type IV compared to type II (P= .016). In the logistic regression analysis, the increase in the degree of primary canal curvature of the ML in CV was a predictive factor for increase in the primary curvature of ML in PV (P = .01). Conclusion: The interorificial distance in the pulp chamber floor and primary curvatures in CV were found to be key factors for evaluation of root canal patterns in PV. © 2006 Mosby, Inc. All rights reserved.