Person: RABUŞ, ŞULE
Loading...
Email Address
Birth Date
Research Projects
Organizational Units
Job Title
Last Name
RABUŞ
First Name
ŞULE
Name
3 results
Search Results
Now showing 1 - 3 of 3
Publication Metadata only Comparison of the protective effects of various antiulcer agents alone or in combination on indomethacin-induced gastric ulcers in rats(ELSEVIER GMBH, 2012) OKUYAN, BETÜL; Izzettin, Fikret Vehbi; Sancar, Mesut; Okuyan, Betul; Apikoglu-Rabus, Sule; Cevikbas, UgurThe aim of this study which was structured with the objective of determination of the optimum protective therapy against the long term NSAID therapy-induced ulcers was to compare the gastro-protective effects of various antiulcer drugs (ranitidine, omeprazole, bismuth and misoprostol)alone or in combination with each other in different doses on indomethacin-induced gastric ulcers in rats. In this experimental study the protective effect of misoprostol (100 mu g/kg/day and 10 mu g/kg/day i.g.), omeprazole (5 mg/kg/day and 1.5 mg/kg/day i.p.), ranitidine (40 mg/kg/day and 10 mg/kg/day i.p.), bismuth (70 mg/kg/day and 15 mg/kg/day i.g.), combinations of misoprostol (10 mu g/kg/day i.g.) plus omeprazole (1.5 mg/kg/day i.p.) and misoprostol (10 mu g/kg/day i.g.) plus ranitidine (10 mg/kg/day i.p.) are investigated on indomethacin (50 mg/kg/day s.c.) induced gastric ulcers. Half an hour before indomethacin administration, each group received the above treatment regimens for 5 days. After 5-day treatment, the rats were sacrificed and histopathological and hematological examinations were performed. The following regimens were found to be effective in the prevention of indomethacin-induced gastric lesions: 100 mu g/kg misoprostol, 10 mu g/kg misoprostol, 5 mg/kg omeprazole, combination of 10 mu g/kg misoprostol plus 1.5 mg/kg omeprazole and 10 mu g/kg misoprostol plus 10 mg/kg ranitidine. The prevention rates achieved by these treatments were 71.4%, 50%, 47.6%, 52.4% and 50%, respectively. As a result of this study, misoprostol and omeprazol were found to be effective in protection against NSAID-induced gastric problems: while, ranitidine and bismuth were not. Also, the combinations of these agents were not found to have additive or synergistic effects. (C) 2010 Elsevier GmbH. All rights reserved.Publication Metadata only Translation and psychometric evaluation of the Turkish version of the pharmacy students' perceptions of preparedness to provide pharmaceutical care scale(GOVI-VERLAG PHARMAZEUTISCHER VERLAG GMBH, 2016) OKUYAN, BETÜL; Okuyan, B.; Sancar, M.; Ay, P.; Demirkan, K.; Apikoglu-Rabus, S.; Izzettin, F. VehbiThe aim of the study is to conduct the psychometric evaluation of the Turkish version of the Pharmacy Students' Perceptions of Preparedness to Provide Pharmaceutical Care (PREP) scale. The present study was conducted at three faculties of pharmacy among fifth-year students during a three-month period in 2015. After the translation process, the Turkish version was developed. Psychometric evaluation consisted of the calculation of inter-rater and test-retest reliability and factor analysis. The mean age of 184 students (71.2% of female) was 23.74 +/- 1.07. The mean score of the Pharmacy Students' PREP scale was 4.54 +/- 1.00 and the Cronbach's alpha was 0.971. Inter-rater and test-retest reliability and factor analysis were also in concordance with the literature. In the present study, the Turkish version of Pharmacy Students' Perceptions of Preparedness to Provide Pharmaceutical Care Scale has been determined to be a reliable and validated tool to assess students' perceptions of preparedness to provide pharmaceutical care.Publication Metadata only The biochemical assessment of the effectsof Nigella sativa oil on cutaneous wound healing in rats(2010-06-09) RABUŞ, ŞULE; SANCAR, MESUT; OKUYAN, BETÜL; AKSOY, HALİL; AKSOY H. Z., RABUŞ Ş., SANCAR M., OKUYAN B., URAS F., İZZETTİN F. V.