Person: RABUŞ, ŞULE
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RABUŞ
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ŞULE
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Publication Metadata only In vitro effects of nitric oxide donors on apoptosis and oxidative/nitrative protein modifications in ADP-activated platelets(SAGE PUBLICATIONS LTD, 2013) ŞENER, AZİZE; Sener, A.; Egemen, G.; Cevik, O.; Yanikkaya-Demirel, G.; Apikoglu-Rabus, S.; Ozsavci, D.Nitric oxide (NO) is an important physiological signaling molecule. However, when produced in excessive amounts, NO can also have toxic effects. The aim of this study is to investigate the effects of exogenous- and endogenous-derived NO on oxidative modifications of proteins and apoptosis in activated platelets. Washed platelets were incubated with L-arginine or nitroso-glutathione (GSNO) in the presence of adenosine diphosphate (ADP). After incubation, caspase-3 activity, phosphatidylserine (PS) externalization and the potential of mitochondrial membrane as markers of apoptosis were measured. In addition, the alterations in protein carbonylation (PCO) and nitrotyrosine (NT) formation as markers of protein oxidation were examined. Platelet activation with ADP (20 p,M) significantly increased PCO and NT levels and apoptotic events. After incubation with L-arginine, platelet NO production increased significantly. This L-arginine-induced increase caused decreases in formerly increased PCO and NT levels associated with ADP-induced platelet activation. Stimulation of NO production with L-arginine protected platelets from apoptosis. GSNO caused an increase in protein NT levels. Despite this change, GSNO was effective in inhibition of P-selectin expression, platelet aggregation, protein carbonylation and apoptosis. The results suggest that L-arginine and GSNO-mediated NO leads to the inhibition of key apoptotic processes including caspase-3 activation, PS exposure and low mitochondrial membrane potential in washed platelets. The inhibitory effect of platelet clearance of L-arginine and GSNO may be a novel useful therapeutic property in clinical application.Publication Metadata only Turkish pharmacists' counseling practices and attitudes regarding emergency contraceptive pills(SPRINGER, 2012) RABUŞ, ŞULE; Apikoglu-Rabus, Sule; Clark, Philip Martin; Izzettin, Fikret V.Objective The aim of this study is to assess Turkish pharmacists' counseling practices and attitudes regarding emergency contraception pills (ECPs). Setting This cross-sectional observational study was conducted via a web-based survey in Turkey. Methods Pharmacists registered at a professional web site (n = 822) were invited to fill in the study questionnaire; 624 questionnaires were completed and further analyzed. Pharmacists who agreed to participate in the study completed the questionnaire which was structured to elicit their demography, professional experience, counseling practices and attitudes regarding ECP. Attitudes were measured by 18 items under four domains: reproductive health; information and availability; risk behavior and regulatory restrictions. The answer choices consisted of five items as: totally agree, agree, neither agree nor disagree, disagree and totally disagree. Main outcome Measures The rate of counseling on various aspects of the ECPs and the rate of negative/positive attitudes. Results The aspects most frequently counseled on by the pharmacists were dosage, timeframes, efficacy and pregnancy testing. Less frequently counseled aspects were mechanism of action, methods of contraception and side-effects. In general, the pharmacists displayed positive attitudes towards all domains of the survey; while they were negative to the items suggesting that ECP should be sold only to women and only on prescription. Another interesting finding is that 58 % of the pharmacists agreed with the item suggesting limiting the ECP sales to those over 18 years of age. Conclusions Our results showed that the pharmacists served the clients in need of emergency contraception more frequently than the other health-care providers and in general had favorable attitudes towards ECP. Some aspects of their counseling practices need to be improved. This can be accomplished through continuous education programs that would equip them with the competence to provide counseling on emergency contraception which will in turn help prevent unintended pregnancies and reduce abortion rates.Publication Open Access Drug-related problems and pharmacist interventions in a cohort of patients with asthma and chronic obstructive pulmonary disease(W B SAUNDERS CO LTD, 2016-11) RABUŞ, ŞULE; Apikoglu-Rabus, Sule; Yesilyaprak, Gozde; Izzettin, Fikret VehbiBackground: Asthma and chronic obstructive pulmonary disease are preventable and treatable chronic airway diseases with high incidence and prevalence. Pharmacists and clinical pharmacy based pharmaceutical care services have positive impact on therapy outcomes. Objective: The aim of this study is to describe drug related problems in a cohort of patients with asthma and chronic obstructive pulmonary disease and to assess interventions provided by the pharmacist to address these problems in a community pharmacy. Method: Study population consisted of patients with asthma and chronic obstructive pulmonary disease older than 18 years who visited the study pharmacy during the pre-determined six-month period. The patients whose disease control states were not fully controlled were included in our study for further steps. On the first interview, present and potential drug related problems were addressed, interventions were provided. Follow-up interviews were held one month and two months later than the first interview. Results: For the 44 patients with asthma, 59 drug-related problems and 134 causes for these problems were identified. Eighty-four interventions were made to resolve the problems; and 54.2% of the problems were resolved. For the 37 patients with chronic obstructive pulmonary disease, 60 drug-related problems and 128 causes for these problems were identified. Ninety-five interventions were made to resolve the problems; and 63.3% of the problems were resolved. Conclusion: Pharmacists taking part in therapy and management of asthma and chronic obstructive pulmonary disease can help patients be more educated about their disease and medications; and improve disease control and therapy outcomes. (C) 2016 Elsevier Ltd. All rights reserved.Publication Metadata only Comparison of the protective effects of various antiulcer agents alone or in combination on indomethacin-induced gastric ulcers in rats(ELSEVIER GMBH, 2012) OKUYAN, BETÜL; Izzettin, Fikret Vehbi; Sancar, Mesut; Okuyan, Betul; Apikoglu-Rabus, Sule; Cevikbas, UgurThe aim of this study which was structured with the objective of determination of the optimum protective therapy against the long term NSAID therapy-induced ulcers was to compare the gastro-protective effects of various antiulcer drugs (ranitidine, omeprazole, bismuth and misoprostol)alone or in combination with each other in different doses on indomethacin-induced gastric ulcers in rats. In this experimental study the protective effect of misoprostol (100 mu g/kg/day and 10 mu g/kg/day i.g.), omeprazole (5 mg/kg/day and 1.5 mg/kg/day i.p.), ranitidine (40 mg/kg/day and 10 mg/kg/day i.p.), bismuth (70 mg/kg/day and 15 mg/kg/day i.g.), combinations of misoprostol (10 mu g/kg/day i.g.) plus omeprazole (1.5 mg/kg/day i.p.) and misoprostol (10 mu g/kg/day i.g.) plus ranitidine (10 mg/kg/day i.p.) are investigated on indomethacin (50 mg/kg/day s.c.) induced gastric ulcers. Half an hour before indomethacin administration, each group received the above treatment regimens for 5 days. After 5-day treatment, the rats were sacrificed and histopathological and hematological examinations were performed. The following regimens were found to be effective in the prevention of indomethacin-induced gastric lesions: 100 mu g/kg misoprostol, 10 mu g/kg misoprostol, 5 mg/kg omeprazole, combination of 10 mu g/kg misoprostol plus 1.5 mg/kg omeprazole and 10 mu g/kg misoprostol plus 10 mg/kg ranitidine. The prevention rates achieved by these treatments were 71.4%, 50%, 47.6%, 52.4% and 50%, respectively. As a result of this study, misoprostol and omeprazol were found to be effective in protection against NSAID-induced gastric problems: while, ranitidine and bismuth were not. Also, the combinations of these agents were not found to have additive or synergistic effects. (C) 2010 Elsevier GmbH. All rights reserved.Publication Metadata only Rhabdomyolysis Secondary to Tetanus Toxoid Administration in a Patient Following Minor Laceration(WILEY, 2011) RABUŞ, ŞULE; Hursitoglu, Mehmet; Cikrikcioglu, Mehmet Ali; Gundogan, Erdal; Ozkan, Oktay; Cordan, Ilker; Yigit, Yildiz; Kara, Osman; Soysal, Pinar; Rabus, Sule Apikoglu; Celepkolu, Tahsin; Tukek, TufanPublication Metadata only Translation and psychometric evaluation of the Turkish version of the pharmacy students' perceptions of preparedness to provide pharmaceutical care scale(GOVI-VERLAG PHARMAZEUTISCHER VERLAG GMBH, 2016) OKUYAN, BETÜL; Okuyan, B.; Sancar, M.; Ay, P.; Demirkan, K.; Apikoglu-Rabus, S.; Izzettin, F. VehbiThe aim of the study is to conduct the psychometric evaluation of the Turkish version of the Pharmacy Students' Perceptions of Preparedness to Provide Pharmaceutical Care (PREP) scale. The present study was conducted at three faculties of pharmacy among fifth-year students during a three-month period in 2015. After the translation process, the Turkish version was developed. Psychometric evaluation consisted of the calculation of inter-rater and test-retest reliability and factor analysis. The mean age of 184 students (71.2% of female) was 23.74 +/- 1.07. The mean score of the Pharmacy Students' PREP scale was 4.54 +/- 1.00 and the Cronbach's alpha was 0.971. Inter-rater and test-retest reliability and factor analysis were also in concordance with the literature. In the present study, the Turkish version of Pharmacy Students' Perceptions of Preparedness to Provide Pharmaceutical Care Scale has been determined to be a reliable and validated tool to assess students' perceptions of preparedness to provide pharmaceutical care.Publication Metadata only Effect of topical insulin on cutaneous wound healing in rats with or without acute diabetes(WILEY-BLACKWELL PUBLISHING, INC, 2010) ERCAN, FERİHA; Apikoglu-Rabus, S.; Izzettin, F. V.; Turan, P.; Ercan, F.Background. Diabetes is a condition known even in its early stages to impair the normal course of wound healing, thus leading to chronic wounds. The role of insulin in the regulation of energy metabolism, protein synthesis, cell differentiation and growth suggests that this hormone could also play an essential role in regulation of wound healing. Aim. To determine the effects of topical insulin administration on wound healing in rats with or without acute diabetes. Methods. This study was conducted using four groups of male Sprague-Dawley rats: (i) nondiabetic rats receiving topical insulin (n = 7), (ii) nondiabetic rats receiving topical sterile water (n = 7), (iii) diabetic rats receiving topical insulin (n = 7) and (iv) diabetic rats receiving topical sterile water (n = 7). Wound healing was assessed by wound contraction rate, complete epithelialization time and histological results. Results. Topical insulin enhanced wound healing by shortening the time needed for complete epithelialization in both the nondiabetic and acute diabetic groups. The histological observations supported the planimetric results in both groups. Conclusions. This study revealed that topical insulin application to cutaneous wounds accelerates wound healing in rats with or without acute diabetes.Publication Metadata only The biochemical assessment of the effectsof Nigella sativa oil on cutaneous wound healing in rats(2010-06-09) RABUŞ, ŞULE; SANCAR, MESUT; OKUYAN, BETÜL; AKSOY, HALİL; AKSOY H. Z., RABUŞ Ş., SANCAR M., OKUYAN B., URAS F., İZZETTİN F. V.