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ATASOY, BESTE MELEK

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ATASOY

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BESTE MELEK

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Start date: 2020 × Subject: Health Sciences ×

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Now showing 1 - 5 of 5
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    The role of radiotherapy in intracranial hemangiopericytoma: TROD CNS group study 07-008
    (2022-05-01) ATASOY, BESTE MELEK; Kaydihan N., Guney Y., Yazici G., Erpolat P., Kamer S., Atasoy B. M., Aslan D., ATALAR B., Demircioglu F., Dincbas F. O., et al.
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    PublicationOpen Access
    Long-term outcomes of gamma-knife radiosurgery for intracanalicular vestibular schwannomas
    (2022-01-01) PINAR, ERTUĞRUL; BAYRİ, YAŞAR; BAYRAKLI, FATİH; SAKAR, MUSTAFA; ATASOY, BESTE MELEK; Sakar M., Pınar E., Bayri Y., Bayraklı F., Atasoy B. M., Ziyal M. İ.
    GİRİŞ ve AMAÇ: Kanal içi vestibüler schwannomalar, tüm vestibüler schwannomalar içerisinde küçük bir yüzdeye sahiptir. Kanal içi vestibüler schwannomalarda işitmenin korunması, hasta yönetiminin temel amaçlarındandır. Bu çalışmanın amacı, kanal içi vestibüler schwannomalarda Gamma-Knife radyocerrahinin (GKR) tümör kontrolü ve işitmenin korunması üzerine etkisinin incelenemesidir.YÖNTEM ve GEREÇLER: Bu geriye dönük çalışmada, Gamma-Knife Radyocerrahi Merkezi’mizde Ocak 2010–Ocak 2020 arasında kanal içi vestibüler schwannoma tanısı ile stereotaksik radyocerrahi almış, klinik, odyometrik ve radyolojik takibi bulunan hastalar değerlendirildi. Tümör kontrolü manyetik rezonans görüntüleme yönteminde tümör boyutlarının ölçülmesi ile takip edildi. İşitme seviyeleri Gardner-Robertson (GR) işitme sınıflaması yöntemine göre değerlendirildi.BULGULAR: Ortalama 48.23 aylık takipte, çalışmaya dahil edilen toplam 45 hastadan 44’ünde tümör kontrolü sağlandığı görüldü (%97.7). Tümör büyümesi görülen bir hastada ise, ek bir tedavi uygulanması gerekmedi. Ek tedavi gerekliliğine göre değerlendirildiğinde tüm hastalarda tümör kontrolü sağlandı (%100). Tedavi öncesi fonksiyonel işitmesi olan (GR derece I ve II) toplam 29 hastadan, ortalama 70.42 aylık takip sonrasında, toplam 13 hastada fonksiyonel işitme korundu (%44.8). GR derecesinde kayıp, ameliyat öncesinde yüksek GR derecesine sahip olmak ile korelasyon gösterdi (Rs=0.459, p=0.002). Tedavi dozu işitme kaybı ile korelasyona sahipti ve daha yüksek doz alan hastalar daha kötü sonuçlara sahipti (Rs=0.459, p=0.002).TARTIŞMA ve SONUÇ: Kanal içi vestibüler schwannomalarda GKR uzun dönemli takiplerde mükemmel tümör kontrolü sağlamaktadır. Beş yılın üzerindeki takip sürelerinde fonksiyonel işitmenin korunma oranı azalabilir. Kanal içi vestibüler schwannomalarda GKR sonrası işitmenin seyrini ortaya koyabilmek için uzun takip süreli daha fazla çalışma gerekmektedir.Anahtar Kelimeler:Gamma-knife radyocerrahi, işitmenin korunması; kanal içi; tümör kontrolü; vestibüler schwannoma.
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    Anxiety and depression level and body appreciation of breast cancer patients who had oncology physician and nurse led education during postoperative radiotherapy
    (2020-10-17) ÖZGEN, ZERRİN; YANARTAŞ, ÖMER; ATASOY, BESTE MELEK; Çankaya G., Özgen Z., Korkmaz A., Yanartaş Ö., Atasoy B. M.
    OP-02 Anxiety and depression level and body appreciation of breast cancer patients who had oncology physician and nurse led education during postoperative radiotherapy Gul Cankaya, Zerrin Ozgen, Ayse Korkmaz, Omer Yanartas, Beste Melek Atasoy Department Of Radiation Oncology Marmara University Pendik Training Hospital Istanbul Turkey INTRODUCTION: In this study, we have investigated effect of education on anxiety and depression levels and body perception of breast cancer patients during postoperative radiotherapy (RT) led by physicians and oncology nurse. MATERIAL-METHODS: Ethical approval was obtained from institutional ethical committee. In this prospective study we have enrolled 50 patients with written consent who were operated and had indication for RT (n = 50). Hospital Anxiety and Depression Scale (HAD-A1 and HAD-D1) and Body Appreciation Scale (BAS-1) were applied to patients after first examination. Then the patients had education on these topics: steps of radiotherapy, side effects and precautions, simulation, main points in simulation, deep breathing for patients operated on the left chest, significance of crunches, doing deep breathing exercise, the factors in skin care during RT, lymphedema, protection from lymphedema, making a breast self-examination, importance of inspection, importance of preventive health screenings and its intervals, importance of nutrition and activity in breast cancer. In line with the demands of patients, they had dietician and psychiatry support. However, radiotherapy skin reactions that may develop on the patient\"s skin during treatment was followed up regularly and complaints were answered. HAD (HAD-A2, HAD-D2) and BAS (BAS-2) were applied again after RT completed. RESULTS: Mean HAD-A1 was 4.9 (0 -15) SD 0.36, whereas HAD-A2 was 1.6 (0-5) SD 1.56. HAD-D1 resulted with average 3.7 (0-16) SD at 3.89 and HAD-D2 with mean 1.08 (0-5) SD 1.17. BAS-1 resulted mean 44.50 (33-50) SD 4.67 and BAS-2 with 46.68 (36-50) SD 3.74. HAD-A scores for 39 patients had decreased with only one increased and 10 remained same. Comparison of anxiety before and after treatment were made by Wilcoxon test; statistically it was found decreased significantly (p <0.05). HAD-D scores of 5 patients over 11 points returned to normal in second test. While HAD-D scores of 35 patients had decrement, 3 patients had mild increase and 12 remained stable. There was a statistically significant improvement in the depression scale (p<0.05). After the treatment, BAS scores had statistically significant increase (p<0.05). DISCUSSION: Anxiety in 3 patients and depression in 5 patients were high but regressed to normal. BAS scores had increment. Patients having regularly information had decreased anxiety and depression scales. It has been found increase in BBS scores. CONCLUSION: HAD-A, HAD-D and BAS scales helped monitoring positive effect of information on patients on RT. Keywords: Breast cancer, Radiotherapy, Hospital anxiety depression scale, Body appreciation scale, Breast cancer education nurse.
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    PublicationOpen Access
    Neuroprotective effect of Myrtus communis against ionizing radiation-induced brain injury: Insights from histopathological and biochemical analysis in rats: TROD-GROG 005
    (2024-12-01) ATASOY, BESTE MELEK; Atasoy B. M.
    Aim: To investigate the potential radioprotective effects of Myrtus communis on brain tissue. Methods: Thirty female rats were divided into four groups. The control group (C) was applied with oral saline solution (SF) for four days. Myrtus communis (MC) groups started to receive MC (100 mg/kg, oral) either four days before (R + preMC) or immediately after (R + MC) irradiation for four days. Irradiation was applied 10 Gy in a single fraction. All rats were sacrificed on the fourth day of irradiation. Malondialdehyde (MDA), nitric oxide (NO), and glutathione (GSH) levels, myeloperoxidase (MPO), superoxide dismutase (SOD), and tissue factor activities (TFa) were determined for biochemical analysis. Hematoxylin&Eosin staining was done for histopathological analyses, and electrophoretic analyses were performed. Results: NO, MDA, and MPO levels were higher in all irradiated groups compared with the C group. MC administration decreased NO, MDA, and MPO levels in R + preMC and R + MC groups. MC administration increased GSH levels. TFa activity decreased in R groups but did not change with MC administration compared to the C group. Radiation-induced brain tissue injury decreased, and morphologically normal neurons were observed in both MC-added groups. Conclusion: Myrtus communis has a potential neuroprotective effect on brain tissue, attributed to its antioxidative, anti-inflammatory, and anti-lipid peroxidative properties.
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    PublicationOpen Access
    Evaluation of Permanent Tooth Development in Pediatric Cancer Survivors: A Single Center Experience
    (2024-09-01) ATASOY, BESTE MELEK; Atasoy B. M.
    Aim: Childhood cancer survival has improved significantly with advances in multimodal treatment. However, treatment-related long-term side effects, including dental developmental abnormalities, remain a concern. The aim of this study was to investigate permanent tooth development and associated risk factors in childhood cancer survivors who were treated before the age of six years, focusing on non-leukemia cases. Materials and Methods: This study was conducted on childhood cancer cases treated with chemotherapy and/or radiotherapy at a single center. Patients diagnosed before the age of six and who were twelve or above at the time of assessment were included. Dental examinations, including Decayed, Missing, Filled Teeth index and radiographic assessments, were performed. Statistical analyses were performed in order to identify associations between treatment modalities and dental findings. Results: Of 914 patients, 90 met the inclusion criteria, with 35 participating in this study. The mean age at diagnosis was four years, with a mean follow-up duration of ten years. Root shortening, hypoplasia, and hypodontia were observed to be common dental anomalies. There was a significant association between alkylating agents, vinca alkaloid plus alkylating agents and root shortening (p<0.001, p<0.001). No significant differences in dental findings were found based on gender, tumor site, or other treatment modalities (p<0.05). As the age at diagnosis increased, the risk of root shortening (p=0.026) and the frequency of hypodontia significantly increased with the duration after diagnosis (p=0.048). Conclusion: Childhood cancer survivors treated during early dentition periods are at risk of dental developmental anomalies, with alkylating agents showing the most significant impact. This emphasizes the necessity of providing these patients and their families with information on the importance of maintaining oral and dental health during and after cancer treatment.