Person: BOZKURTLAR, EMİNE
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BOZKURTLAR
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EMİNE
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Publication Metadata only Differences in PET/CT standardized uptake values involvement and survival compared to histologic subtypes of lung adenocarcinoma(SAGE PUBLICATIONS LTD, 2021) BOZKURTLAR, EMİNE; Ercelep, Ozlem; Alan, Ozkan; Telli, Tugba A.; Tuylu, Tugba B.; Arikan, Rukiye; Demircan, Nazim Can; Simsek, Eda T.; Babacan, Nalan A.; Kaya, Serap; Dane, Faysal; Bozkurtlar, Emine; Ones, Tunc; Lacin, Tunc; Yumuk, Perran FuldenPurpose: Lung adenocarcinoma is histologically diverse but has distinct histologic growth patterns. There is no consensus on the clinical benefit of this histologic model. We aimed to evaluate the differences in the distribution of the preoperative primary tumor positron emission tomography (PET)/computed tomography (CT) standardized uptake values (SUVs) and survival in the lung adenocarcinoma subtypes. Methods: We retrospectively evaluated the data of 107 patients with resected lung adenocarcinoma who had preoperative PET/CT between 2005 and 2017 in a single center. Patients had lepidic, acinar, papillary, micropapillary, and solid histologic subtypes. We compared fluorodeoxyglucose SUVs and survival data of histologic subtypes. Results: The median age of the patients was 62 years (40-75), 76.4% were male, the median SUVmax was 9.4 (1-36.7), and the median follow-up time was 29 months (3-135 months). The median overall survival (OS) was 71 months and the median progression-free survival (PFS) was 33 months. SUVmax was significantly different in histologic subtypes: values for papillary, micropapillary, solid, acinar, and lepidic subtypes were 9.7, 8, 12, 9.1, and 3.9, respectively (p= 0.000). Solid predominant adenocarcinoma had significantly higher SUVmax than the other subtypes (p= 0.001). Lepidic predominant adenocarcinoma had significantly lower SUVmax than the other subtypes (p= 0.000). There was no significant difference in OS between histologic subtypes (p= 0.66), but PFS was significantly different between the groups (p= 0.017), and the solid subtype had a shorter PFS than the other histologic subtypes. Conclusion: Lung adenocarcinoma consists of a diverse group of diseases. Different SUVmax values are seen in different histologic subtypes of nonmetastatic lung adenocarcinoma. Solid predominant types have high SUVmax values while lepidic predominant types have lower SUVmax values. The solid subtype had a shorter PFS than the other histologic subtypes.Publication Metadata only Histopathological evaluation of post-mortem pulmonary specimens excised from ICU patients with COVID-19: Do we know what we do not know(2023-05-06) ERMERAK, NEZİH ONUR; BOZKURTLAR, EMİNE; KOCAKAYA, DERYA; GÜL, FETHİ; KARAKURT, SAİT; ERMERAK N. O., BOZKURTLAR E., KOCAKAYA D., GÜL F., KARAKURT S., Cinel I.Publication Metadata only Protective effect of cysteinyl leukotriene receptor antagonist montelukast in bleomycin-induced pulmonary fibrosis(BAYCINAR MEDICAL PUBL-BAYCINAR TIBBI YAYINCILIK, 2018) CEYHAN, BERRİN; Topaloglu, Nurhayat; Yildizeli, Sehnaz Olgun; Sener, Goksel; Lacin, Tunc; Sehirli, Ozer; Bozkurtlar, Emine; Celikel, Cigdem; Ceyhan, BerrinBackground: This study aims to investigate the early- and late-term effects of pharmacological inhibition of cysteinyl leukotriene activity by using montelukast in bleomycin-induced inflammatory and oxidative lung injury in an animal model. Methods: The study included 48 male Wistar albino rats (weighing 250 g to 300 g). Rats were administered intratracheal bleomycin or saline and assigned into groups to receive montelukast or saline. Bronchoalveolar lavage fluid and lung tissue samples were collected four and 15 days after bleomycin administration. Results: Bleomycin resulted in significant increases in tumor necrosis factor-alpha levels (4.0 +/- 1.4 pg/mL in controls vs. 44.1 +/- 14.5 pg/mL in early-term vs. 30.3 +/- 5.7 pg/mL in late-term, p<0.001 and p<0.001, respectively), transforming growth factor beta 1 levels (28.6 +/- 6.6 pg/mL vs. 82.3 +/- 14.1 pg/mL in early-term vs. 60.1 +/- 2.9 pg/mL in late-term, p<0.001 and p<0.001, respectively), and fibrosis score (1.85 +/- 0.89 in early-term vs. 5.60 +/- 1.14 in late-term, p<0.001 and p<0.01, respectively). In bleomycin exposed rats, collagen content increased only in the late-term (15.3 +/- 3.0 mu g/mg in controls vs. 29.6 +/- 9.1 mu g/mg in late-term, p<0.001). Montelukast treatment reversed all these biochemical indices as well as histopathological alterations induced by bleomycin. Conclusion: Montelukast attenuates bleomycin-induced inflammatory and oxidative lung injury and prevents lung collagen deposition and fibrotic response. Thus, cysteinyl leukotriene receptor antagonists might be regarded as new therapeutic agents for idiopathic pulmonary fibrosis.Publication Metadata only The Importance of Lymph Node Drainage Areas of Ampullary Carcinomas(2022-03-01) BOZKURTLAR, EMİNE; BAĞCI ÇULÇİ, PELİN; Akar K., BOZKURTLAR E., BAĞCI ÇULÇİ P., Balci S.Publication Metadata only Centrally-necrotic/hyalinizing demarcated (CND) carcinomas of the pancreas: A clinico-pathologically distinct group with divergent metaplastic patterns and high-grade characteristics(2022-03-01) BAĞCI ÇULÇİ, PELİN; BOZKURTLAR, EMİNE; Cengiz D., Saka B., BAĞCI ÇULÇİ P., Altinmakas E., Bozkurt E., Armutlu A., PEHLİVANOĞLU B., BOZKURTLAR E., Reid M., Mericoz M. A., et al.Publication Metadata only Endobronchial ultrasound transbronchial needle aspiration in elderly patients: safety and performance outcomes EBUS-TBNA in elderly(TAYLOR & FRANCIS LTD, 2020) TUFAN ÇİNÇİN, ASLI; Yildizeli, Sehnaz Olgun; Tufan, Asli; Bozkurtlar, Emine; Arikan, Huseyin; Kocakaya, Derya; Eryuksel, Emel; Ceyhan, Berrin; Karakurt, SaitAim Complication rates are low and endobronchial ultrasound guided needle aspiration (EBUS-TBNA) is generally regarded as a safe procedure, but there is a very limited number of studies evaluating the efficacy and safety of the procedure in advanced ages. The aim of this study is to assess the safety and performance outcomes of EBUS-TBNA in elderly. Methods It was a retrospective observational study; patients who received EBUS-TBNA between September 2016 and January 2018 were evaluated. We analyzed patient's characteristics, doses of midazolam, and lidocaine used, regions of lymph node biopsies, and complications. Also, functionality and general physical status of patients over 65 years of age were evaluated. Results During study period 132 cases of EBUS-TBNA were evaluated. 39 (29.5%) cases were aged 70 years, and over. There were more comorbidities in older group. Performance status of older group was worse. Furthermore, when evaluated according to American College of Cardiology (ACC)/American Heart Association (AHA) and American Society of Anesthesiologists (ASA), the older group was found to be composed of the riskier patients. When patients aged between 65 and 69, and over 70 compared, older patient's Barthel, EQ 5-D, SGA, and G8 scores were found to be worse. Despite that, there was no difference in the frequency, and types of complications between both groups. Diagnostic performance was not different between age groups. Conclusions Independent from comorbidities, general health status, and functionality EBUS-TBNA procedure in 70-year-old and over patients is a safe minimally invasive procedure.Publication Metadata only Pulmoner nodül rezeksiyonu yapılan olgularda klinik radyolojik bulguların malign histopatolojik tanılar ile korelasyonu(2023-05-09) OLGUN YILDIZELİ, ŞEHNAZ; KOCAKAYA, DERYA; ERMERAK, NEZİH ONUR; BOZKURTLAR, EMİNE; ERYÜKSEL, SEMİHA EMEL; ÇİMŞİT, NURİ ÇAGATAY; YILDIZELİ, BEDRETTİN; KARAKURT, SAİT; OLGUN YILDIZELİ Ş., GİVİVİ S., KOCAKAYA D., ERMERAK N. O., BOZKURTLAR E., ERYÜKSEL S. E., ÇİMŞİT N. Ç., YILDIZELİ B., KARAKURT S.Pulmonary nodules are common (nc(dental f(nd(ng on thorac(c computed tomography (CT) and st(ll a problem (n da(ly pulmonary pract(ce. Because of the w(dely usage of CT scans an (ncreased number of pat(ents follow up w(th th(s d(agnose. Nodules may or(g(nated secondary to ben(gn d(seases but pr(mary concern (s mal(gnanc(es wh(ch (s (mportant for early d(agnos(s and curat(ve opt(ons. On the other hand (t (s not cost-effect(ve follow(ng up the ben(gn les(ons w(th an add(t(onal cumulat(ve rad(at(on dose espec(ally (n prolonged durat(on. Many pred(ct(on models were proposed to evaluate the potency of mal(gnancy us(ng cl(n(cal and rad(olog(cal f(nd(ngs Mayo cl(n(c (1), Veterans Assoc(at(on (2), Brock Un(vers(ty (3) and lastly Herder model (4) mostly used models for r(sk strat(f(cat(on. Herder r(sk model evaluates also Flour(ne– flourodeoxyglucose (FDG) uptake (n pos(tron em(ss(on tomography-computed tomography (PET-CT). Comparat(ve study of these models showed non-super(or(ty to each other, added value of PET-CT (s unden(able for larger nodules but not clear for small nodules (< 8mm) (5). Mult(d(sc(pl(nary follow up, careful observat(on and d(agnost(c test(ng are st(ll h(ghly recommended espec(ally for (ndeterm(ne nodulesPublication Metadata only Endotracheal metastasis of colon cancer on FDG PET/CT(WILEY, 2021) BOZKURTLAR, EMİNE; Filizoglu, Nuh; Oksuzoglu, Kevser; Ozguven, Salih; Bozkurtlar, Emine; Ones, Tunc; Erdil, Tanju YusufAlthough tracheal involvement of lung cancer is frequently seen, endotracheal metastasis of colon cancer is a rare entity. Since endotracheal lesion gives no symptom until tracheal lumen nearly occluded, the diagnosis of endotracheal metastasis could be challenging. F-18 fluorodeoxyglucose positron emission tomography/computed tomography may be crucial to detect this unusal distant metastasis of colon cancer. Herein, we report FDG avid endotracheal lesion that was confirmed as metastasis from colon cancer in 56-year-old female patient.Publication Metadata only Pulmoner arter sarkomanın cerrahi sonuçları: Histoloji sağkalımı etkiler mi(2023-08-01) BOZKURTLAR, EMİNE; OLGUN YILDIZELİ, ŞEHNAZ; MUTLU, BÜLENT; KOCAKAYA, DERYA; BEKİROĞLU, GÜLNAZ NURAL; YILDIZELİ, BEDRETTİN; Başar V., Olgun Yıldızeli Ş., Bozkurtlar E., Ercelep ., Mutlu B., Kocakaya D., Bekiroğlu G. N., Taş S., Sunar H., Küçükoğlu M. S., et al.Publication Metadata only Is Perineural Invasio (PN) a Determinant of Disease Free Survival in Early Stage Colorectal Cancer?(H G E UPDATE MEDICAL PUBLISHING S A, 2015) ÇELİKEL, ÇİĞDEM; Ozturk, Mehmet Akif; Dane, Faysal; Karagoz, Sila; Tural, Deniz; Selcukbiricik, Fatih; Demirelli, Fuat; Buyukunal, Evin; Ozguroglu, Mustafa; Turna, Hande; Erdamar, Sibel; Celikel, Cigdem Ataizi; Bozkurtlar, Emine Bas; Yumuk, Perran Fulden; Mandel, Nil Molinas; Turhal, Nazim Serdar; Serdengecti, SuheylaBackground/Aims: The prognostic importance of perineural invasion (PN) in colorectal cancer (CRC) is unclear. The aim of this study to find out whether the PN was an independent stratification factor of postoperative relapse in curatively resected high-risk stage II & III CRC patients who were treated with adjuvant therapy. Methodology: Data of patients with high risk stage II & all stage III CRCs treated with adjuvant chemotherapy were retrospectively analyzed. Pathological features of final surgical specimen were noted. Disease-free survival was determined by Kaplan-Meier estimator, with differences determined by multivariate analysis using the Cox multiple hazards model. Results were compared using the log-ranktest. Results: PN was found to be positive in 26% in the files of 593 eligible patients. In 21% of the reports PN status was not reported. Presence of PN in the resected primary tumors did not have independent effect on DFS. Further analyses for importance of PN on DFS of colon or rectal cancers did not show any effect. Conclusions: This study had failed to demonstrate any prognostic effect of PN for DFS in surgically resected stage II and III CRC patients who received adjuvant treatments.