Person: YAVUZ, DİLEK
Loading...
Email Address
Birth Date
Research Projects
Organizational Units
Job Title
Last Name
YAVUZ
First Name
DİLEK
Name
5 results
Search Results
Now showing 1 - 5 of 5
Publication Metadata only Vitamin D receptor gene BsmI, FokI, ApaI, TaqI polymorphisms and bone mineral density in a group of Turkish type 1 diabetic patients(SPRINGER-VERLAG ITALIA SRL, 2011) YAVUZ, DİLEK; Yavuz, Dilek Gogas; Keskin, Lezan; Kiyici, Sinem; Sert, Murat; Yazici, Dilek; Sahin, Ibrahim; Yuksel, Meral; Deyneli, Oguzhan; Aydin, Hasan; Tuncel, Ercan; Akalin, SemaPrevious studies have suggested an influence of vitamin D receptor alleles on bone metabolism and on susceptibility to type 1 diabetes mellitus in different ethnic populations. We aimed to investigate the distribution of vitamin D receptor (VDR) alleles in relation to biochemical bone turnover parameters and bone densitometry measurements in a group of Turkish type 1 diabetic patients. One hundred and seventeen patients (M/F 57/60, 27.6 +/- A 7.3 y duration of diabetes 8.1 +/- A 6.3 y) and 134 healthy controls (M/F 61/73, 26.2 +/- A 5.3 y) were included in the study. Bone mineral density (BMD) was evaluated by dual-energy X-ray absorptiometry (DEXA). The vitamin D receptor gene (VDR) polymorphisms FokI, Bsm1, Apa1, and Taq1 were examined using a PCR-based restriction analysis. Serum levels of calcium, phosphor osteocalcin, intact parathyroid hormone, and C telopeptide were measured. Vitamin D receptor Bsm1 Fok1, Apa1, and Taq1 genotype distributions were not different between patient with diabetes and control groups. BMD was 0.77 +/- A 0.2 g/cm(2) vs. 0.97 +/- A 0.2 g/cm(2) (P = 0.0001) for the femur, 1.0 +/- A 0.1 g/cm(2) vs. 1.13 +/- A 0.1 g/cm(2) (P = 0.001) for type 1 diabetic patients and controls. Bone turnover markers were significantly lower in type 1 diabetic group. BMD measurements and bone metabolic markers were not different between the genotypes in either the patient with diabetes or the controls. The VDR gene polymorphisms, Bsm1, Fok 1, Apa1, and Taq1 showed no influence on bone metabolism in our group of type 1 diabetic patients.Publication Open Access Effects of ACE inhibition and Angiotensin II receptor blockade on glomerular basement membrane protein excretion and charge selectivity in Type 2 diabetic patients(J R A A S LTD, 2006-06) VELİOĞLU ÖĞÜNÇ, AYLİZ; Deyneli, Oguzhan; Yavuz, Dilek; Velioglu, Ayliz; Cacina, Hasan; Aksoy, Nihal; Haklar, Goncaguel; Taga, Yavuz; Akalin, SemaAngiotensin-converting enzyme (ACE) inhibitors may reduce urinary albumin excretion (UAE) by decreasing glomerular pressure and increasing glomerular charge selectivity through preservation of glycosaminoglycans. The effect of Angiotensin II antagonism on glomerular charge selectivity remains to be determined. The aim of this study was to compare the effects of an AT, blocker losartan and an ACE inhibitor (ACE-I) enalapril on UAE, extracellular matrix proteins, glycosaminoglycan excretion(U-GAG) and red blood cell anionic charge (RBCCh) which are the indirect markers of glomerular basement membrane anionic content in hypertensive Type 2 diabetic patients. Twenty-four patients were randomised into two groups and received either enalapril (5-20 mg/d) or losartan (50-100 mg/d). All parameters were measured at baseline and after six months of treatment. At the end of six months, systolic and diastolic blood pressures (BP), UAE rates, U-GAG excretion and RBCCh were significantly and equally reduced in both treatment groups compared with baseline. RBCCh was negatively correlated with UAE (r = -0.57, p < 0.0001) and U-GAG excretion (r = -0.57, p < 0.0001); UAE was correlated with U-GAG excretion (r = 0.58, p < 0.0001). In conclusion, enalapril and losartan treatment were equally effective in reducing BP, UAE as well as U-GAG excretion and preserving RBCCh in hypertensive Type 2 diabetic patients. ACE inhibition and AT(1)-receptor blockade may have favourable effects on preserving glomerular anionic content in hypertensive diabetic patients.Publication Metadata only Serum Adipokine Levels in Type 1 Diabetic Patients: Association with Carotid Intima Media Thickness(MARY ANN LIEBERT INC, 2012) YAVUZ, DİLEK; Yazici, Dilek; Yavuz, Dilek; Ogunc, Ayliz Velioglu; Sirikci, Onder; Toprak, Ahmet; Deyneli, Oguzhan; Akalin, SemaBackground: Adipokines are markers of insulin resistance and play a role in the atherosclerotic process. The association of adipokines with the macrovascular complications of type 1 diabetes mellitus (DM) needs to be determined. The aim of this study was to measure serum adiponectin, leptin, and resistin levels in type 1 DM patients and investigate their relationship with carotid intima media thickness (CIMT), a clinical marker of atherosclerosis. Methods: Seventy-five type 1 DM patients and 115 sex and age-matched healthy controls were included in the study. Serum adiponectin, leptin, and resistin levels were measured by the enzyme-linked immunosorbent assay (ELISA method). CIMT was assessed by Doppler ultrasonography Results: Adiponectin levels in diabetics were higher (25.8 +/- 14.8 mg/mL vs. 5.5 +/- 7.3 mg/mL; P<0.0001) and leptin levels were lower than controls (9.4 +/- 6.2 ng/mL vs. 12.8 +/- 8.6 ng/mL; P=0.01). Resistin levels were also higher in the diabetic group compared to controls (2.1 +/- 1.4 ng/mL vs. 1.6 +/- 0.8 ng/mL; P=0.04). Adiponectin was correlated negatively with CIMT (r=-0.24, P=0.03), age (r=-0.30, P=0.02), BMI (r=-0.33, P=0.02), waist-to-hip ratio (WHR) (r=-0.38, P=0.01) and positively with creatinine (r=0.44, P=0.004). Leptin levels were correlated with total cholesterol (r=0.53, P=0.01) and high-density lipoprotein (HDL) (r=0.67, P=0.001). Resistin was correlated with CIMT (r=0.24, P=0.03) and systolic blood pressure (r=0.48, P=0.009). Multivariate analysis revealed resistin and creatinine to be independent predictors of CIMT among adiponectin, leptin, resistin, WHR, glycosylated hemoglobin (HbA1c), and creatinine. Conclusions: Increased adiponectin correlates negatively and resistin positively with CIMT in type 1 diabetic patients, but adjusting for other known predictors reveals only resistin to be associated with subclinical atherosclerosis in this group of patients.Publication Metadata only The effect of losartan and captopril on glomerular basement membrane anionic charge in a diabetic rat model(LIPPINCOTT WILLIAMS & WILKINS, 1999) YAVUZ, DİLEK; Yavuz, DG; Ersoz, O; Kucukkaya, B; Budak, Y; Ahiskali, R; Ekicioglu, G; Emerk, K; Akalin, SObjective Although angiotensin-converting enzyme inhibitors are known to reduce albuminuria by preserving glomerular basement membrane anionic content, the effects of angiotensin II receptor blockage are currently not known. The aim of this study was to evaluate the effects of captopril and losartan on glomerular basement membrane anionic charges in a diabetic rat model. Design After diabetes induction with streptozotocin, female Wistar rats were divided into three groups: group A, losartan 10 mg/kg by gavage (n = 8); group B, captopril 50 mg/l in drinking water (n = 6); group C, diabetic control rats (n = 8) given only tap water. Group D (eight rats) served as non-diabetic controls. At the end of 8 weeks, erythrocyte membrane charge, serum sialic acid, urinary glycosaminoglycan and albumin were measured and kidney specimens stained with Alcian blue in order to assess basement membrane glycosaminoglycans. Results Red blood cell anionic charges (ng Alcian blue/10(6) red blood cells) were 371.5 +/- 9.9 for group A, 443.5 +/- 7.1 for group B, 400.1 +/- 14.7 for group C, 468.7 +/- 4 for group D (A < D, C < D, P < 0.01). Serum sialic acid levels (mg/dl) were 90.6 +/- 14.1 for group A, 45.6 +/- 6.8 for group B, 89.1 +/- 8.5 for group C, 50.8 +/- 6.4 for group D (A, C > D, P < 0.01; A > B P < 0.01). Albuminuria (mu g/day) was 778 +/- 221 for group A, 719 +/- 314 for group B, 1724 +/- 945 for group C, 393 +/- 263 for group D (A, B < C, P < 0.05). Urinary glycosaminoglycan/creatinine ratio was 14.2 +/- 1.1 for group A, 9.9 +/- 1 for group B; 28.3 +/- 8 for group C, 5.5 +/- 1.7 for group D (B < C, P < 0.001; B < A, P < 0.003). Alcian blue staining was 1.8 +/- 0.2, 2.2 +/- 0.4, 1.5 +/- 0.16, 2.8 +/- 0.2 for groups A, B, C and D respectively (C, A < D P < 0.05). Conclusion Losartan and captopril have comparable effects on reducing albuminuria in a diabetic rat model. While captopril preserves basement membrane anionic charges, losartan has no effect. The anti-proteinuric effects of these drugs seem to have different mechanisms. I Hypertens 1999, 17:1217-1223 (C) Lippincott Williams & Wilkins.Publication Open Access Diurnal Blood Pressure Abnormalities Are Related to Endothelial Dysfunction in Patients with Non-Complicated Type 1 Diabetes(NATURE PUBLISHING GROUP, 2008-11) YAVUZ, DİLEK; Deyneli, Oguzhan; Yazici, Dilek; Toprak, Ahmet; Yuksel, Meral; Aydin, Hasan; Tezcan, Hakan; Yavuz, Dilek Gogas; Akalin, SemaPatients with diabetes have an increased cardiovascular morbidity and mortality despite interventions to prevent these outcomes. Abnormalities in diurnal blood pressure patterns are also associated with excess cardiovascular mortality. The aim of this study was to determine the effects of diurnal blood pressure patterns on endothelial function and oxidative stress in patients with uncomplicated type 1 diabetes mellitus. Thirty-two normotensive and normoalbuminuric type 1 diabetic patients (21 dipper and 11 nondipper) and 37 healthy (27 dipper and 10 nondipper) volunteers underwent 24-h ambulatory blood pressure monitoring. Their endothelial functions were evaluated using flow mediated dilatation (FMD) and by measuring nitric oxide and thiobarbituric acid reactive substances (TBARS). Dippers were defined as subjects who exhibited an average reduction in both systolic and diastolic blood pressure of greater than 10% between day and night periods. Nondipper type 1 diabetic patients and controls had nighttime systolic and diastolic blood pressure values that were significantly higher than those of dipper diabetic patients (p<0.05) and dipper controls (p<0.01). Values of FMD for nondipper diabetic patients (5.12 +/- 2.2%) were significantly lower than those In dipper diabetic patients (10.19 +/- 2.5%, p<0.01), nondipper (10.08 +/- 2.9%, p<0.001) and dipper controls (11.76 +/- 0.8%, p<0.001). Additionally, levels of TBARS In the dipper diabetic group and dipper controls were significantly lower than those in the nondipper diabetic group (p<0.05). In conclusion, only type 1 diabetic patients with a nondipping pattern of blood pressure exhibited changes that may lead to endothelial dysfunction and atherosclerosis. (Hypertens Res 2008; 31: 2065-2073)