Person: AK, ESİN
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AK
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ESİN
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Publication Metadata only Neuroprotective effects of mitoquinone and oleandrin on Parkinson's disease model in zebrafish(TAYLOR & FRANCIS LTD, 2020) ALTURFAN, EBRU IŞIK; Unal, Ismail; Caliskan-Ak, Esin; Ustundag, Unsal V.; Ates, Perihan S.; Alturfan, Ahmet A.; Altinoz, Meric A.; Elmaci, Ilhan; Emekli-Alturfan, EbruAim: The aim of this study is to investigate the possible protective effects of mitoquinone and oleandrin on rotenone induced Parkinson's disease in zebrafish. Materials and methods: Adult zebrafish were exposed to rotenone and mitoquinone for 30 days. Biochemical parameters were determined by spectrophotometric method and Parkinson's disease-related gene expressions were determined by reverse transcription polymerase chain reaction method. Measurement of neurotransmitters was performed by liquid chromatography tandem-mass spectrometry instrument. The accumulation of synuclein was demonstrated by immunohistochemical staining. In vitro thiazolyl blue tetrazolium bromide method was applied to determine the mitochondrial function of synaptosomal brain fractions using rotenone as a neurotoxic agent and mitoquinone and oleandrin as neuroprotective agents. Results: Mitoquinone improved the oxidant-antioxidant balance and neurotransmitter levels that were disrupted by rotenone. Mitoquinone also ameliorated the expressions of Parkinson's disease-related gene expressions that were disrupted by rotenone. According to thiazolyl blue tetrazolium bromide assay results, mitoquinone and oleandrin increased mitochondrial function which was decreased due to rotenone exposure. Conclusion: Based on the results of our study, positive effects of mitoquinone were observed in Parkinson's disease model induced by rotenone in zebrafish.Publication Metadata only Kronik periodontitisli ve sağlıklı kişilerin tükürük örneklerinin bazı biyokimyasal parametreler ve sitolojik incelemeler açısından karşılaştırılmasında saklama süresinin belirlenmesi(2009-06-20) ALTURFAN, EBRU IŞIK; YARAT, AYŞEN; AK, ESİN; ALTURFAN E. I., YARAT A., AK E., PİŞİRİCİLER R., KURU B., NOYAN Ü.Publication Metadata only Zebra balığı barsak dokusunda doku faktörü ekspresyonunun incelenmesi(2015-03-08) AK, ESİN; ALTURFAN, EBRU IŞIK; ÜSTÜNDAĞ Ü. V., AK E., ALTURFAN E. I.Publication Metadata only Bisphenol A reveals its obesogenic effects through disrupting glucose tolerance, oxidant-antioxidant balance, and modulating inflammatory cytokines and fibroblast growth factor in zebrafish(2022-01-01) ALTURFAN, EBRU IŞIK; AK, ESİN; Beler M., Cansız D., Ünal İ., Üstündağ Ü. V., Dandin E., Ak E., Alturfan A. A., Emekli-Alturfan E. I.Obesogens affect lipid metabolism, and genetic or epigenetic factors may also contribute to the progression of obesity. Endocrine-disrupting chemicals (EDCs) are the most striking among obesogens. Bisphenol A (BPA) is an estrogenic EDC used in food containers, adhesives, dye powders, and dental fillers. We aimed to elucidate molecular mechanisms of BPA\"s obesogenic effects focusing on obesogenic pathways in the liver including fibroblast growth factor (FGF) and Dnmt3a which is its epigenetic regulator, oxidant-antioxidant status, and inflammatory cytokines. Zebrafish were divided into three groups as control, low-dose BPA (1 mu m BPA), and high-dose BPA groups (10 mu m BPA). At the end of 30 days, oral glucose tolerance test (OGTT) was performed, fasting blood glucose levels were measured, and hepatopancreas tissues were taken. Malondialdehyde (MDA) levels, superoxide dismutase (SOD), glutathione S-transferase (GST), and nitric oxide (NO) activities were examined in the hepatopancreas. Inflammatory cytokines, lepa, fgf21, and dnmt3a expressions were determined by RT-PCR. BPA exposure increased the body weights, il1ss, tnf alpha, il6, lepa, fgf21, and dnmt3a expressions, impaired glucose tolerance, and oxidant-antioxidant status in a dose-dependent manner. Hepatocyte degeneration, lipid vacuolization, and vasocongestion were observed in both BPA-exposed groups. Our study suggests impaired glucose tolerance, oxidant-antioxidant balance, increased inflammatory response, fgf21 expression, and dnmt3a expressions as the possible mechanisms for the BPA-induced obesity model in zebrafish.Publication Metadata only The Protective Role of Chard (Beta Vulgaris L. Var. Cicla) on Amiodarone Induced Submandibular Gland Injury in Rats(2020-10-01) AK, ESİN; AK E., TÜRKYILMAZ İ. B.Publication Metadata only Fibrin sealant induces periodontal tissue healing after tooth replantation in rats.(2012-05-27) AK, ESİN; ÇETİNEL, ŞULE; DEMİREL S., AKYÜZ S. H., YALVAÇ M. E., AK E., ÇETİNEL Ş.Publication Metadata only Sudan Kaçınma Stresi ile Oluşturulan İnterstisyel Sistit Modelinde Oksitosinin Etkisi(2014-05-30) AK, ESİN; ÇETİNEL, ŞULE; AK E., ÇİKLER E., ŞEHİRLİ A. Ö., ŞENER G., TETİK Ş., ÇETİNEL Ş.Publication Metadata only Histological Evaluation of the Effect of Baicalin On Cyclophosphamide Induced Testicular Damage in Rats(2023-03-19) AK, ESİN; ALTAY, GÜLSEREN; ALTAY G., AK E.Publication Metadata only Cytological investigation of saliva samples of disabled children(2013-07-11) ALTURFAN, EBRU IŞIK; AK, ESİN; YARAT, AYŞEN; PİŞİRİCİLER R., ALTURFAN E. I., OZBAY G., AK E., AKYÜZ S. H., YARAT A.Publication Metadata only In vitro effect of aqueous plant extracts on antioxidant parameters in saliva samples(2011-11-13) YARAT, AYŞEN; AK, ESİN; YARAT A., SAÇAN Ö., AKYÜZ S. H., PİŞİRİCİLER R., AK E., YANARDAĞ R.
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