Person: APAYDIN, TUĞÇE
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APAYDIN
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TUĞÇE
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Publication Open Access Prevalence of vitamin d deficiency and hypervitaminosis d among adult patients admitted to the tertiary care hospitals in Turkey(2022-06-01) YAVUZ, DİLEK; APAYDIN, TUĞÇE; HAKLAR, GONCAGÜL; YAVUZ D., ERSOY R., Altuntas Y., Bilen H., Pamuk B., APAYDIN T., Temizkan S., Altuntas H., Mert M., AKALIN A., et al.Objective: Vitamin D deficiency is a common health problem around the world. This study aimed to evaluate the nationwide prevalence of vitamin D status in tertiary care hospitals in Turkey. Methods: Retrospectively, the data on vitamin D levels from 33 tertiary care hospitals’ clinical biochemistry laboratories around Turkey between January and December were collected. Results: In total, 706 434 serum samples from adult subjects (female/male: 469 028/237 406; 66.4%/33.6%) were included. While vitamin D levels were sufficient in 20.3% (n=14 222), they were insufficient in 21.9% (n=154 360) and deficient in 57.8% (n=408 882). We observed the highest rates of deficiency in those aged between 18 and 29 years (62.9%, n=70 235) and lowest rates between 60 and 69 years (52.3%, n=61 121) and between 70 and 79 years (52.3%, n=32 397). Hypervitaminosis D was detected in 5.5% of adult subjects; highest rates of hypervitaminosis D were observed in those who were over 80 years (6.6%) and 70-79 years (6.5%) and the lowest in 18-29 years (2.8%). Discussion: In this cohort, over half of the subjects admitted to the tertiary care hospitals in Turkey had vitamin D deficiency and required vitamin D supplementation. The elderly population had the lowest prevalence of vitamin D insufficiency and the highest prevalence of hypervitaminosis D.Publication Metadata only Does concomitant prolactin measurement increase the accuracy of inferior petrosal sinus sampling?(SPRINGER, 2022) YAVUZ, DİLEK; Apaydin, Tugce; Yasar, Mehmet; Baltacioglu, Feyyaz; Haklar, Goncagul; Yavuz, Dilek GogasIntroduction Prolactin (PRL) measurement during inferior petrosal sinus sampling (IPSS) can be helpful to improve the accuracy. We aimed to evaluate the effect of measuring PRL levels as a predictor for the accuracy of IPSS and evaluate its impact on the lateralization of adenomas. Methods In this retrospective cohort study, we reviewed 51 patients who had undergone IPSS for the investigation of ACTH-dependent hypercortisolism. Results Forty-nine patients had proven Cushing's disease (CD), one had EAS, and the remaining one patient had adrenal adenoma. Forty-seven patients had an above 2 ACTH IPS/P ratio at baseline, and all the post-corticotropin-releasing hormone (CRH) ACTH IPS/P ratios of patients with proven CD were above 3. In these two patients whose ACTH IPS/P ratio at baseline was below 2, PRL IPS/P ratios were above 1.8 in only the dominant side, which was considered secondary to a prolactin intersinus gradient due to the biological effects of the tumor. PRL-adjusted ACTH IPS/P ratios were > 1.3 in all patients with proven CD; it was 0.7 in the patient with EAS. Surgically confirmed positive lateralization was observed in 55.1% of patients with the ACTH gradient, but when PRL-adjusted ACTH IPS/IPS ratios were used in addition to the ACTH gradient, the ratio increased to 67.3%. Conclusion Although PRL-adjusted ACTH IPS/P ratios can be helpful to improve the accuracy of results during IPSS procedures, a prolactin intersinus gradient towards the ACTH-dominant side in patients with CD may invalidate PRL as an indicator of pituitary venous outflow.Publication Metadata only The association of free testosterone levels with coronavirus disease 2019(2022) ILGIN, CAN; Apaydin, Tugce; Sahin, Bahadır; Dashdamirova, Saida; Dincer Yazan, Ceyda; Elbasan, Onur; Ilgin, Can; Bilgin, Hüseyin; Cam, Haydar Kamil; Bahramzada, Gunel; Kucuk, Aleyna; Haklar, Goncagul; Iliksu Gozu, Hulya