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APAYDIN, TUĞÇE

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Author: YAVUZ, DİLEK × Subject: Klinik Tıp ×

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Now showing 1 - 4 of 4
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    PublicationOpen Access
    Prevalence of vitamin d deficiency and hypervitaminosis d among adult patients admitted to the tertiary care hospitals in Turkey
    (2022-06-01) YAVUZ, DİLEK; APAYDIN, TUĞÇE; HAKLAR, GONCAGÜL; YAVUZ D., ERSOY R., Altuntas Y., Bilen H., Pamuk B., APAYDIN T., Temizkan S., Altuntas H., Mert M., AKALIN A., et al.
    Objective: Vitamin D deficiency is a common health problem around the world. This study aimed to evaluate the nationwide prevalence of vitamin D status in tertiary care hospitals in Turkey. Methods: Retrospectively, the data on vitamin D levels from 33 tertiary care hospitals’ clinical biochemistry laboratories around Turkey between January and December were collected. Results: In total, 706 434 serum samples from adult subjects (female/male: 469 028/237 406; 66.4%/33.6%) were included. While vitamin D levels were sufficient in 20.3% (n=14 222), they were insufficient in 21.9% (n=154 360) and deficient in 57.8% (n=408 882). We observed the highest rates of deficiency in those aged between 18 and 29 years (62.9%, n=70 235) and lowest rates between 60 and 69 years (52.3%, n=61 121) and between 70 and 79 years (52.3%, n=32 397). Hypervitaminosis D was detected in 5.5% of adult subjects; highest rates of hypervitaminosis D were observed in those who were over 80 years (6.6%) and 70-79 years (6.5%) and the lowest in 18-29 years (2.8%). Discussion: In this cohort, over half of the subjects admitted to the tertiary care hospitals in Turkey had vitamin D deficiency and required vitamin D supplementation. The elderly population had the lowest prevalence of vitamin D insufficiency and the highest prevalence of hypervitaminosis D.
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    PublicationOpen Access
    Morbid obesity leads to increased skin autofluorescence independent of metabolic syndrome components
    (2022-01-01) APAYDIN, TUĞÇE; YAVUZ, DİLEK; APAYDIN T., YAVUZ D.
    Background/aim: Obesity, diabetes mellitus, and metabolic syndrome (MetS) are associated with increased accumulated skin advanced glycation end products. We aimed to evaluate the association of MetS components with skin autofluorescence (SAF) in patients with morbid obesity. Material and methods: Eight hundred and one patients with morbid obesity and 94 age-matched controls with normal body mass index (BMI) and normal glucose metabolism were included. Advanced glycation end products (AGEs) were measured using SAF in the forearm, with an AGE reader. Results: The prevalence of MetS in patients with morbid obesity was 65.5% (n = 525). Type 2 diabetes mellitus (type 2 DM) and hypertension were present in 40.9% (n = 328) and 43.7% (n = 357). Patients with morbid obesity and those with MetS had higher SAF measurements compared with the control group, 1.85 ± 0.44 arbitrary unit (AU) and 1.86 ± 0.43 AU vs. 1.72 ± 0.30 AU, respectively (p = 0.016). There was no difference in SAF levels between patients with and without MetS. SAF measurements of patients without MetS were not statistically different from the control group (p = 0.076). Patients with five MetS criteria had higher SAF measurements compared with patients with fewer MetS components (p = 0.019). There was no difference in SAF levels between patients with type 2 DM, impaired glucose metabolism, and patients with normal glucose metabolism (p = 0.513). Conclusion: Although MetS and type 2 DM are known as factors related to increased SAF levels, obesity can cause elevated SAF measurements in different ways independent of concomitant comorbid diseases. Larger studies with longer follow-ups are needed to enlighten the underlying mechanism.
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    PublicationMetadata only
    Diyabetik ketoasidoz
    (Akademisyen Yayınevi Kitabevi, 2024-01-01) APAYDIN, TUĞÇE; YAVUZ, DİLEK; Apaydın T., Yavuz D.
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    PublicationOpen Access
    Clinical predictors of incipient vertebral fractures and bone mineral density in kidney transplant patients
    (2022-09-01) APAYDIN, TUĞÇE; VELİOĞLU, ARZU; YAVUZ, DİLEK; BUĞDAYCI, ONUR; TUĞLULAR, ZÜBEYDE SERHAN; YAVUZ D., Aydin K., Apaydin T., VELİOĞLU A., Mert M., Pekkolay Z., Parmaksiz E., Mese M., Pazir A. E., Aydin E., et al.
    © 2022, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.Purpose: Kidney transplant recipients are prone to metabolic bone diseases and consequent fractures. This study aimed to evaluate the incidence of incipient vertebral fractures, osteopenia, osteoporosis, and the clinical factors associated with incipient vertebral fractures in a group of kidney transplant patients. Methods: Two hundred sixty-four patients (F/M 124/140, 45.3 ± 13 years) who had undergone kidney transplantation in tertiary care centers were included. Vertebral fractures were assessed semiquantitatively using conventional thoracolumbar lateral radiography in 202 of the patients. Results: Vertebral fractures were observed in 56.4% (n = 114) of the study group. The frequency of osteoporosis was 20.0% (53 of 264 patients), and osteopenia was 35.6% (94 of 264 patients). Bone mineral density (BMD) levels were in the normal range in 40.3% (n = 46) of the subjects with vertebral fractures. It was in the osteoporotic range in 20.1% (n = 23) and the osteopenic range in 40.3% (n = 46). Vertebral fractures were associated with age, duration of hemodialysis, BMI, and femoral neck Z score (R2 37.8%, p = 0.027). Conclusion: As incipient vertebral fractures can be observed in patients with normal BMD levels in kidney transplant recipients, conventional X-ray screening for vertebral fractures may be beneficial for a proper therapy decision of metabolic bone disease in kidney transplant recipients.