Person: YUMUŞAKHUYLU, ALİ CEMAL
Loading...
Email Address
Birth Date
Research Projects
Organizational Units
Job Title
Last Name
YUMUŞAKHUYLU
First Name
ALİ CEMAL
Name
11 results
Search Results
Now showing 1 - 10 of 11
Publication Open Access Effect of the pandemic on surgical procedures in a tertiary care hospital: A retrospective review(2022-09-01) SAÇAK, BÜLENT; KESİMER, MEHMET DENİZ; ŞAHİN, BAHADIR; UĞURLU, MUSTAFA ÜMİT; SAKAR, MUSTAFA; YUMUŞAKHUYLU, ALİ CEMAL; Ozkan M. C. , SAÇAK B., KESİMER M. D. , ŞAHİN B., UĞURLU M. Ü. , Sirzai E. Y. , SAKAR M., Aykut A., Cicek I., YUMUŞAKHUYLU A. C.Objective: The aim of this study was to examine the impact of performing surgeries with necessary precautions and to evaluate demographic characteristics of operated patients during novel coronavirus-2019 (COVID-19) pandemic and the infection rates during hospitalization and within 14 days after surgery.Publication Open Access Thyroid Surgery and Inadvertent Removal of Parathyroids(SPRINGER INDIA, 2021-06-01) YUMUŞAKHUYLU, ALİ CEMAL; Asya, Orhan; Yumusakhuylu, Ali Cemal; Gundogdu, Yavuz; Incaz, Sefa; Oysu, CagatayThis study aimed to determine the incidence of inadvertent parathyroid removal during thyroid surgery and define its associated risk factors. In this single-center record-based study, we retrospectively analyzed the clinical and pathological records of 462 patients undergoing thyroidectomy. Incidental parathyroidectomy was detected in 61 of 462 patients (13.2%). The incidence of inadvertent parathyroid removal was 17.6% (36 of 205 patients) in patients having malign thyroid diseases, compared with 9.7% (25 of 257 patients) in patients with benign thyroid diseases (p = 0.045). Incidentally removed parathyroid tissue was intrathyroidal in 8 of the 61 patients. Thus, the ratio of intrathyroidal parathyroid tissue among all patients was 1.7% (8 out of 462). Central neck dissection was carried out in 40 patients (8.7%). Fourteen of these 40 patients (35%) had an incidental parathyroid in their specimen compared with 47 of 422 patients (11.1%) who did not undergo central neck dissection (p<0.001). Incidental parathyroidectomy occurred in 13.2% of patients undergoing thyroidectomy in our study. The majority of patients had one parathyroid identified in their specimen. Central neck dissection was significantly predictive for incidental parathyroidectomy. Well-trained senior otolaryngology residents can safely perform thyroid surgery with similar rates of incidental parathyroidectomy as their masters.Publication Metadata only Ki̇sti̇k fi̇brozi̇s tanili hastalarda odyoloji̇k bulgular(2022-03-10) ÇİPRUT, AYŞE AYÇA; YUMUŞAKHUYLU, ALİ CEMAL; GÖKDEMİR, YASEMİN; ERDEM ERALP, ELA; ÇİPRUT A. A., Öztürk N., Toktaş F., YUMUŞAKHUYLU A. C., YILMAZ YEĞİT C., ERGENEKON P., GÖKDEMİR Y., ERDEM ERALP E.Publication Metadata only Diagnostic Features and Risk Factors for Childhood Thyroid Cancers(2022-09-01) ŞAHİN, PINAR; GÜRPINAR TOSUN, BUŞRA; YUMUŞAKHUYLU, ALİ CEMAL; GÜRAN, TÜLAY; HALİLOĞLU, BELMA; OYSU, ÇAĞATAY; DEMİRCİOĞLU, SERAP; BEREKET, ABDULLAH; ŞAHİN P., GÜRPINAR TOSUN B., YUMUŞAKHUYLU A. C. , GÜRAN T., Helvacioglu D., Abali Z. Y. , HALİLOĞLU B., OYSU Ç., BEREKET A., DEMİRCİOĞLU S.Publication Open Access Relationship of PPARG overexpression with prognostic parameters in papillary thyroid carcinoma(2022-02-01) ASYA, ORHAN; YUMUŞAKHUYLU, ALİ CEMAL; BAĞCI ÇULÇİ, PELİN; ŞAHİN, AKIN; OYSU, ÇAĞATAY; KAYA, HANDAN; ASYA O., YUMUŞAKHUYLU A. C., BAĞCI ÇULÇİ P., KAYA H., Gonen A., Gundogdu Y., Muradov T., ŞAHİN A., OYSU Ç.Objectives. PAX8/PPARG chromosomal rearrangement is frequently seen in thyroid cancer, and PPARG overexpression has been shown in the follicular variant of papillary thyroid carcinoma, but not in papillary thyroid carcinoma other than the follicular variant. The main aim of this study was to investigate the frequency of PPARG overexpression among papillary thyroid carcinoma and if there were any variants of papillary thyroid carcinoma with PPARG overexpression other than the follicular variant. Methods. Immunohistochemical analysis of PPARG overexpression was performed using a PPARG monoclonal antibody in a series of 111 paraffin-embedded blocks of thyroid tumours. Of the patients in our study, 100 were diagnosed with papillary thyroid carcinoma, 9 with follicular adenoma and 2 with follicular carcinoma. Results. PPARG staining was detected in 19 of the 111 cases. Sixteen patients with PPARG overexpression had papillary thyroid carcinoma and 3 had follicular adenoma. Conclusion. PPARG overexpression was detected mainly in follicular-variant papillary thyroid carcinoma. Vascular invasion, lymphatic invasion, thyroid capsule invasion and lymph node positivity were lower in patients with PPARG overexpression.Publication Open Access Clinicopathologic Results of the Surgical Management of Thyroid Gland Pathologies(GALENOS YAYINCILIK, 2020-07-10) YUMUŞAKHUYLU, ALİ CEMAL; Yumusakhuylu, Ali Cemal; Asya, Orhan; Gundogdu, Yavuz; Oysu, CagatayObjective: The aim of this study is to share our surgical approach and results in patients with benign and malignant thyroid diseases. Methods: All patients who underwent thyroid gland surgery at our University Hospital Ear, Nose, and Throat Department between 2012 and 2017 were retrospectively analyzed. The study included 293 patients. Results: Of the 293 patients included in the study, 76 (25.9%) were male and 217 (74.1%) were female. Mean follow-up period was 47.1 months. Patients' ages ranged from 4 to 77 years. In terms of the pathology, 160 patients had benign and 133 had neoplastic thyroid diseases. None of the patients who underwent thyroid surgery due to benign diseases required revision surgery. Recurrence occurred in 15 out of the 116 patients that were operated on for well-differentiated thyroid cancer. Out of these 15 patients with disease recurrence, 11 had biochemically incomplete responses and four had structurally recurrent diseases. Conclusion: Thyroidectomy, when performed safely and correctly, is a very effective way of treating both benign and malignant thyroid diseases. Total thyroidectomy or total lobectomy and isthmectomy are the gold-standard surgical approaches to prevent recurrence. A national form is needed regarding thyroid surgery for following up on patients and for the regular and systematic collection of data.Publication Open Access Oncologic Results of Supracricoid Laryngectomy: Results From Two Tertitory Centers(2020-01-01) ENVER, NECATİ; YUMUŞAKHUYLU, ALİ CEMAL; OYSU, ÇAĞATAY; ENVER N., ŞAHİN A., YUMUŞAKHUYLU A. C. , ŞAHİN YILMAZ A. A. , OYSU Ç.INTRODUCTION: Larynx cancer is the second most frequent head and neck cancer and important cause of morbiditity and mortality. Supracricoid laryngectomy is one of the open partial laryngeal surgerical techniques which is an important tool for treatment of laryngeal cancer. The purpose of this study was to evaluate the oncological outcomes of laryngeal carcinoma patients treated with supracricoid laryngectomy. METHODS: A total of 47 cases were retrospectively analyzed from two tertiarian head and neck clinics with laryngeal carcinoma that underwent supracricoid laryngectomy from 2009 to 2019. Sociodemographic characteristics, histopathologic characteristics of tumor specimens, and survival analysis were assessed. RESULTS: Early stage laryngeal cancer was detected in 29 (61.7%) of the patients, and 20 (38.3%) of the patients had advanced laryngeal cancer. In 29 cases (61.7%) larynx cancer was located in glottis and lymph node involvement was found to be significantly less in cases with glottic location (p< 0.001). While 5-year overall survival was 74.5%, 5-year overall survival was 88.5% and 69.2% in early and advanced stage cases. DISCUSSION AND CONCLUSION: The two most important factors in the determination of successful treatment in treating laryngeal cancer are survival time and preserving laryngeal function. Supracricoid laryngectomy is one of the key tools used in treating laryngeal cancers. Through preserving a healthy larynx in appropriate patients, it is possible to provide permanent improvement while adhering to the surgical technique and oncological rules.Publication Open Access Primer siliyer diskinezide kulak burun boğaz sorunlarına yaklaşım(Türkiye Klinikleri, 2022-01-01) YUMUŞAKHUYLU, ALİ CEMAL; ASYA, ORHAN; Yumuşakhuylu A. C., Gündoğdu Y., Asya O.Publication Open Access Evaluation of LRIG1 expression in larynx pathologies(2022-03-01) CİNEL, ZELİHA LEYLA; YUMUŞAKHUYLU, ALİ CEMAL; Gündoğdu Y., Asya O., Gönen A., Muradov T., Erçetin S. Y., Cinel Z. L., Yumuşakhuylu A. C.Objective: Studies have been performed on many biomolecules to determine the prognosis of LSCC and predict the course of the disease. However, a molecular marker that can be used clinically has not yet been found. Therefore, in this study, we aimed to investigate the expression levels of LRIG 1 in laryngeal cancer. Materials and Methods: In our study, 219 cases who underwent surgery due to LSCC and 88 randomly selected patients whose pathologic result were benign and premalignant lesions in Marmara University Pendik Education and Research Hospital between 2003 and 2018 were analyzed. Patients’ data were obtained from the medical records. The tissue microarray method was used to evaluate specimens. Results: There was a statistically significant difference between the tumor differentiation, diagnosis, and the expression of LRIG1 (respectively p=0.045, p<0.001). Also, an increase in the degree of dysplasia in premalignant lesions correlates with a decrease in LRIG1 expression (p=0.015). Conclusion: Our findings suggest that LRIG1 plays a role in the early tumorigenesis of LSCC. Therefore, LRIG1 can be a target molecule for treatment approaches. However, LRIG1 was not correlated with overall survival of the LSCC.Publication Open Access A single-center multidisciplinary study analyzing thyroid nodule risk stratification by comparing the thyroid imaging reporting and data system (TI-RADS) and American thyroid association (ATA) risk of malignancy for thyroid nodules(2022-01-01) ASYA, ORHAN; YUMUŞAKHUYLU, ALİ CEMAL; ENVER, NECATİ; İNCAZ, SEFA; GÜNDOĞMUŞ, CEMAL AYDIN; ERGELEN, RABİA; BAĞCI ÇULÇİ, PELİN; OYSU, ÇAĞATAY; ASYA O., YUMUŞAKHUYLU A. C. , ENVER N., Gündoğdu Y., Abuzaid G., İNCAZ S., GÜNDOĞMUŞ C. A. , ERGELEN R., Bağcı P., OYSU Ç.© 2022 Elsevier LtdObjectives: The thyroid imaging reporting and data system (TI-RADS) and 2015 American Thyroid Association (ATA) guidelines are two well-known risk stratification systems for classifying thyroid nodules based on cancer risk. This study aims to evaluate the diagnostic efficacy of these two systems in predicting malignancy in patients undergoing thyroid surgery. Methods: We studied data on 120 individuals who were scheduled to undergo surgery for benign or malignant nodular diseases of the thyroid gland between October 2017 and October 2019. The TI-RADS category and ultrasound pattern based on ATA guidelines were assigned to dominant thyroid nodule categories by two experienced radiologists blinded to patients’ previous thyroid ultrasonography and fine-needle aspiration biopsy results. A pathologist with experience in thyroid diseases blinded to patients’ sonographic and clinical data reviewed the thyroidectomy specimens. Results: A total of 120 patients, 88 women and 32 men, were included in our study. Final histopathological results were as follows: 50% (n=60) papillary thyroid carcinoma, 36.6% (n=44) benign nodular thyroid diseases, 4.1% (n=5) follicular adenoma, 2.5% (n=3) hurtle cell adenoma, 1.7% (n=2) follicular thyroid carcinoma, 1.7% (n=2) medullary thyroid carcinoma, 1.7% (n=2) hurtle cell carcinoma, and 1.7% (n=2) follicular tumor of uncertain malignancy potential. The sensitivity, specificity, positive predictive value, and negative predictive value for TI-RADS were 80%, 56%, 72%, and 67%, respectively, and that for ATA were 80%, 64%, 76%, and 69%, respectively. Conclusion: The TI-RADS and ATA showed similar rates of sensitivity, specificity, NPV, and PPV. Our observed risk of malignancy was higher than expected for the ACR TI-RADS 3–5 categories and the very low, low, and intermediate suspicion risk strata in the ATA guidelines. We found no difference between observed and expected malignancy risk for the ACR TI-RADS 2’s and ATA\"s high suspicion categories.