Person: GÜVENÇ, YAHYA
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GÜVENÇ
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YAHYA
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Publication Metadata only Servikal spondilotik myelopati. prognoz ve prognozu etkileyen faktörler(Türkiye Klinikleri, 2018-01-01) HARMAN, FERHAT; GÜVENÇ, YAHYA; HARMAN F., AYTAR M. H., GÜVENÇ Y., Çobanoğlu M., KAPTANOĞLU E.Servikal spondilotik miyelopati (SSM), 55 yaş üzeri kişilerde kazanılmış spinal kord disfonksiyonunun en sık sebebidir. SSM progresif ve dejeneratif bir spinal kord hastalığıdır ve doğal seyri her hastada farklı bir süreç izler. Bu sebeple hastalarda prognoza çok sayıda faktör etki eder. Üstelik oluşan nörolojik bozukluklar ve fonksiyon kayıpları hastaların tedavisine rağmen tamamen düzelmeyebilir. Bu yüzden her hastaya özgün prognozu ve prognoza etki edecek faktörleri bilmek en uygun takip ve tedaviyi seçmekte çok önemlidir.Publication Metadata only Punica granatum L. Juice Attenuates Experimental Cerebral Vasospasm in the Rabbit Subarachnoid Hemorrhage Model: A Basilar Artery Morphometric Study and Apoptosis(THIEME MEDICAL PUBL INC, 2017) GÜVENÇ, YAHYA; Guvenc, Yahya; Demirci, Adnan; Billur, Deniz; Aydin, Sevim; Ozeren, Ersin; Bayram, Pinar; Dilli, Alper; Gokce, Emre Cemal; Yaman, Onur; Celik, Haydar; Karatay, Mete; Alagoz, Fatih; Kaptanoglu, ErkanBackground This study investigated the effect of Punica granatum L. (pomegranate) juice on the rabbit basilar artery in an experimental subarachnoid hemorrhage (SAH) model. Methods Eighteen adult male New Zealand white rabbits were randomly divided into three groups: a control group (n = 6), SAH group (n = 6), and SAH + treatment group (n = 6). Basilar artery diameter was measured with magnetic resonance angiography (MRA) in all groups at the beginning of the study. Experimental SAH was created by injecting autologous arterial blood into the cisterna magna. In the treatment group, the subjects were administered a daily dose of 30 ml/kg pomegranate juice via gastric gavage for 4 days after the SAH. The SAH group and SAH + treatment group underwent cerebral MRA after 72 hours. After a neurologic score assessment, all the animals were killed. The wall thickness and lumen area of the basilar artery were measured histometrically in all groups, and the apoptotic cell percentage in the artery was identified. The mean diameter of the basilar artery during MRA was measured. Results Pomegranate improved neurologic functions compared with the SAH group (p < 0.01). The mean basilar artery diameter on MRA in the SAH + treatment group was larger than in the SAH group and smaller than in the control group (p < 0.01 and p < 0.05, respectively). The mean vessel wall thickness value in the SAH + treatment group was lower than in the SAH group (p < 0.01), whereas there was no difference between the control and the SAH + treatment group (p > 0.05). The apoptotic cell rate in the SAH + treatment group was significantly lower than in the SAH group (p < 0.001). Evaluation of the basilar artery luminal area showed no difference between the three groups (p > 0.05). Discussion Pomegranate was shown to have a vasospasm-attenuating effect on the basilar artery in the rabbit SAH model for the first time in our study.Publication Metadata only ICA Anevrizmaları(2019-04-14) GÜVENÇ, YAHYA; GÜVENÇ Y.Publication Open Access Evaluation of topical Dexmedetomidine administration in postlaminectomy epidural fibrosis rat model(ELSEVIER SCIENCE BV, 2018-05) GÜVENÇ, YAHYA; Yaman, M. E.; Ergul, G.; Guvenc, Y.; Ozturk, Y.; Erbay, F. K.; Tolunay, T.; Senturk, S.; Kircil, C.; Bozkurt, G.Epidural fibrosis is a challenging topic in spinal surgery. Numerous clinical and experimental studies have been focused on this issue to clarify problems faced in spinal procedures for the patient as well as the surgeon and find out new methodologies. Dense cytokines and growth factors which are released from inflammatory cells have been suggested to play a major role in the inception and progression of fibrosis. One of the most investigated and important actor in epidural fibrosis is assumed to be the transforming growth factor-1 beta (TGF-1 beta) formation. Studies showed that Dexmedetomidine (DEX) downregulates TGF-beta pathway with its anti-inflammatory and antioxidant effects. From this point of view, for the first time in the literature we try to observe if there will be an effect of topical DEX administration over epidural fibrosis in a rat model. We hypothesized that DEX might have preventive effects on epidural fibrosis via anti-inflammatory and antioxidant effects. Twenty-four adult male Wistar albino rats were randomly assigned to three groups (Topical DEX, Spongostan, Laminectomy). A total laminectomy was performed at the L3-L5 level and then the ligamentum flavum and epidural fat tissue were cleared away from the surgical site. Histopathological assessment was performed postoperatively after 4 weeks. Our study revealed that topical DEX administration may have effects on reducing epidural fibrosis. Topical DEX administration may be helpful in preventing epidural fibrosis after laminectomy in rats through multiple anti-inflammatory and antioxidant mechanisms as well as through TGF -1 beta pathway.Publication Metadata only Omurilik tümörleri(2019-04-14) GÜVENÇ, YAHYA; GÜVENÇ Y.