Person: AKBAY, TUĞBA
Loading...
Email Address
Birth Date
Research Projects
Organizational Units
Job Title
Last Name
AKBAY
First Name
TUĞBA
Name
8 results
Search Results
Now showing 1 - 8 of 8
Publication Metadata only Edaravone ameliorates the adverse effects of valproic acid toxicity in small intestine(SAGE PUBLICATIONS LTD, 2015) YARAT, AYŞEN; Oktay, S.; Alev, B.; Tunali, S.; Emekli-Alturfan, E.; Tunali-Akbay, T.; Koc-Ozturk, L.; Yanardag, R.; Yarat, A.Valproic acid (VPA) is a drug used for the treatment of epilepsy, bipolar psychiatric disorders, and migraine. Previous studies have reported an increased generation of reactive oxygen species and oxidative stress in the toxic mechanism of VPA. Edaravone, a free radical scavenger for clinical use, can quench free radical reaction by trapping a variety of free radical species. In this study, effect of edaravone on some small intestine biochemical parameters in VPA-induced toxicity was investigated. Thirty seven Sprague Dawley female rats were randomly divided into four groups. The groups include control group, edaravone (30 mg(-1) kg(-1) day(-1)) given group, VPA (0.5 g(-1) kg(-1) day(-1)) given group, VPA + edaravone (in same dose) given group. Edaravone and VPA were given intraperitoneally for 7 days. Biochemical parameters such as malondialdehyde, as an index of lipid peroxidation(LPO), sialic acid (SA), glutathione levels and glutathione peroxidase, glutathione-S-transferase, superoxide dismutase, catalase, myeloperoxidase, alkaline phosphatase (ALP), and tissue factor (TF) activities were determined in small intestine samples by colorimetric methods. Decreased small intestine antioxidant enzyme activities, increased LPO and SA levels, and increased activities of ALP and TF were detected in the VPA group. Based on our results edaravone may be suggested to reverse the oxidative stress and inflammation due to VPA-induced small intestine toxicity.Publication Metadata only Effect of black cumin seed oil on gastric tissues in experimental conditions(2010-11-04) ALTURFAN, EBRU IŞIK; YARAT, AYŞEN; AKBAY, TUĞBA; AK, ESİN; ALTURFAN E. I., YARAT A., AKBAY T., IŞIK F., YENİDOĞAN G., ŞENER G., ŞEHİRLİ A. Ö., PİŞİRİCİLER R., AK E., ALTINTAŞ A.Publication Metadata only The effect of Myrtus communis L. ethanol extract on the small intestine and lungs in experimental thermal burn injury(PERGAMON-ELSEVIER SCIENCE LTD, 2020) ŞEN, ALİ; Ozcan, Ozan; Ipekci, Hazal; Alev, Burcin; Ustundag, Unsal Veli; Sen, Ali; Emekli-Alturfan, Ebru; Sener, Goksel; Yarat, Aysen; Tunali-Akbay, TugbaThermal trauma can damage organs away from the skin burn site and lead to multiple organ dysfunction. Following thermal injury, all tissues are exposed to ischemia, and as a result, resuscitation and reperfusion occur during the burning shock. Burn damage starts systemic inflammatory reactions that produce toxins and reactive oxygen radicals that lead to peroxidation. This study aimed to investigate, for the first time, the possible antioxidant effects of Myrtus communis ethanol extract on burn-induced oxidative distant organ injury orally. The thermal trauma was generated under ether anesthesia by exposing the dorsum of rats to 90 degrees C water bath for 10 s. 100 mg/kg/day Mrytus communis ethanol extract was applied orally for two days. Malondialdehyde (MDA) and glutathione (GSH) levels, glutatinone-S-transferase (GST), superoxidedismutase (SOD) and catalase (CAT) activities were determined to detect the possible antioxidant effects of myrtle on small intestine and lung tissues. Burn damage significantly increased MDA levels in lung and small intestine tissues, and significantly decreased GSH levels, CAT and GST activities in the small intestine and lung tissues compared to control group. Mrytus communis ethanol extract decreased MDA level and increased GSH level, SOD, CAT and GST activities significantly in either small intestine or lung tissues. Mrytus communis extract may be an ideal candidate to be used as an antioxidant adjunct to improve oxidative distant organ damage to limit the systemic inflammatory response and decreasing the recovery time after thermal injury.Publication Metadata only Investigation of the toxicologic and biochemical effects of silk fibroin/gold nanoparticles-based nanofiber using zebrafish embryos(2023-01-01) ALTURFAN, EBRU IŞIK; AKBAY, TUĞBA; Ozcan O., TUFAN E., Ünal İ., ALTURFAN E. I., AKBAY T.Publication Metadata only Effect of stinging nettle seed oil on gastric tissues in experimental colitis(2010-11-04) ALTURFAN, EBRU IŞIK; YARAT, AYŞEN; AKBAY, TUĞBA; AK, ESİN; ALTURFAN E. I., YARAT A., GENÇ Z., YENİDOĞAN G., AKBAY T., ŞENER G., ŞEHİRLİ A. Ö., PİŞİRİCİLER R., AK E., ALTINTAŞ A.Publication Metadata only Effects of Chard (Beta VulgarisL. Var. Cicla) on Cardiac Damage in Valproic Acid-Induced Toxicity(WILEY, 2016) YARAT, AYŞEN; Ustundag, Unsal Veli; Tunali, Sevim; Alev, Burcin; Ipekci, Hazal; Emekli-Alturfan, Ebru; Akbay, Tugba Tunali; Yanardag, Refiye; Yarat, AysenThe aim of this study was to examine the effects of chard on valproic acid (VPA)-induced cardiac damage. Female Sprague-Dawley rats were grouped as control, chard given control (100mg/kg/day, by gavage), VPA (500mg/kg/day, intraperitoneally) and chard given VPA (100mg/kg/day chard by gavage, 500mg/kg/day VPA, intraperitoneally). The aqueous extracts of chard leaves were given 1h prior to administration of VPA for 7 days. Malondialdehyde (MDA), total sialic acid (SA) levels and catalase (CAT) activity significantly increased in the VPA group compared with the control group (P<0.05). Chard administration significantly decreased MDA and SA levels in the control and in the VPA groups (P<0.05). Chard administration also significantly increased CAT activities and glutathione levels both in the control and in the VPA groups (P<0.05). As a conclusion, chard consumption may prevent cardiac tissue from oxidative stress and inflammation in VPA-induced toxicity. Practical ApplicationsValproic acid (VPA) is an antiepileptic drug and has severe toxic effects in experimental animals and humans. Chard (Beta vulgarisL. var. cicla) has antioxidant, antidiabetic, antitumor and hepatoprotective effects. Its protective effects against VPA toxicity have not been fully investigated yet. According to the results of this study, chard (B.vulgarisL. var. cicla) can be used as a dietary food supplement in the epilepsy treatment. The beneficial effect of chard consumption is an important finding in a nutritional point of view as chard contains many significant bioactive constituents for a healthy diet.Publication Metadata only The effect of vitamin U on the lung tissue of pentyleneterazole-induced seizures in rats(SPRINGER, 2018) YARAT, AYŞEN; Oktay, Sehkar; Bayrak, Gamze; Alev, Burcin; Ipekci, Hazal; Ustundag, Unsal Veli; Turkyilmaz, Ismet Burcu; Pisiriciler, Rabia; Emekli-Alturfan, Ebru; Tunali-Akbay, Tugba; Yanardag, Refiye; Yarat, AysenThe aim of this study is to investigate the therapeutic effects of vitamin U (Vit U) on lung tissue of pentyleneterazole (PTZ)-induced seizures in rats. Sprague Dawley male rats were randomly divided into four groups as follows: control (0.9% NaCl given, intraperitoneally); Vit U (50 mg/kg/day, for 7 days by gavage); PTZ; (60 mg/kg one dose, intraperitoneally); and PTZ + Vit U (in same dose and time). At the end of the experiment, lung tissues were taken and examined biochemically and cytologically. Lipid peroxidation (LPO), glutathione (GSH), sialic acid (SA), and nitric oxide (NO) levels, and superoxide dismutase (SOD) and catalase (CAT) activities were determined in lung homogenates. Imprinted lung samples were stained with May Grunwald-Giemsa stain and microscopically examined for the presence of collagen fibers, macrophage, leucocyte, and epithelial cells. PTZ administration significantly increased GSH level and CAT activity and significantly decreased SOD activity compared to the control group. Vit U administration significantly increased GSH level and CAT activity compared to the control group. GSH and NO levels significantly decreased in PTZ + Vit U group compared to the PTZ group. In cytologic analysis, increased collagen fibers, macrophages, leucocytes, and epithelial cells were observed in PTZ group compared to the control group, and Vit U administration decreased these cytological parameters compared to the PTZ group. The findings of this study support the possible protective role of using Vit U as an add-on therapy in order to prevent lung tissue injury which may occur during seizures in epilepsy.Publication Metadata only Protective effect of Myrtle (Myrtus communis) on burn induced skin injury(ELSEVIER SCI LTD, 2019) ŞEN, ALİ; Ozcan, Ozan; Ipekci, Hazal; Alev, Burcin; Ustundag, Unsal Veli; Ak, Esin; Sen, Ali; Alturfan, Ebru Emekli; Sener, Goksel; Yarat, Aysen; Cetinel, Sule; Akbay, Tugba TunaliThermal skin burns cause local injury as well as triggers acute systemic inflammation response where the imbalance between oxidative and antioxidative system occurs. As an alternative treatment, various medicinal herbs are used to treat burn injuries in many countries. In this study, the possible protective role of oral or topical Myrtle (Myrtus communis L.) treatment against burn-induced damage was investigated. The dorsum of the Wistar Albino rats was shaved and exposed to 90 degrees C water bath in burn group or 25 degrees C water bath in control group for 10 s under ether anesthesia. Myrtle extract was applied 100 mg/kg/day for 2 days either orally or topically. In skin samples; malondialdehyde and glutathione levels, catalase, superoxide dismutase, nitric oxide and tissue factor activities were determined. Skin tissues were also examined by light microscopy. Severe thermal skin bum injury caused a significant decrease in glutathione level, superoxide dismutase, catalase and tissue factor activities as well as nitric oxide level, which was accompanied with significant increases in skin malondialdehyde level. Myrtle treatment reversed all these biochemical indices except topical Myrtle treated group's nitric oxide level, as well as histopathological alterations, which were induced by thermal trauma. Both oral and topical Myrtle extract treatment was found to have protective role in the bum induced oxidative injury, which may be attributed to the potential antioxidant effect of Myrtle. As a conclusion, Myrtle significantly diminishes burn-induced damage in skin. (C) 2019 Elsevier Ltd and ISBI. All rights reserved.