Person: AKBAY, TUĞBA
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AKBAY
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TUĞBA
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Publication Metadata only Effects of Chard (Beta VulgarisL. Var. Cicla) on Cardiac Damage in Valproic Acid-Induced Toxicity(WILEY, 2016) YARAT, AYŞEN; Ustundag, Unsal Veli; Tunali, Sevim; Alev, Burcin; Ipekci, Hazal; Emekli-Alturfan, Ebru; Akbay, Tugba Tunali; Yanardag, Refiye; Yarat, AysenThe aim of this study was to examine the effects of chard on valproic acid (VPA)-induced cardiac damage. Female Sprague-Dawley rats were grouped as control, chard given control (100mg/kg/day, by gavage), VPA (500mg/kg/day, intraperitoneally) and chard given VPA (100mg/kg/day chard by gavage, 500mg/kg/day VPA, intraperitoneally). The aqueous extracts of chard leaves were given 1h prior to administration of VPA for 7 days. Malondialdehyde (MDA), total sialic acid (SA) levels and catalase (CAT) activity significantly increased in the VPA group compared with the control group (P<0.05). Chard administration significantly decreased MDA and SA levels in the control and in the VPA groups (P<0.05). Chard administration also significantly increased CAT activities and glutathione levels both in the control and in the VPA groups (P<0.05). As a conclusion, chard consumption may prevent cardiac tissue from oxidative stress and inflammation in VPA-induced toxicity. Practical ApplicationsValproic acid (VPA) is an antiepileptic drug and has severe toxic effects in experimental animals and humans. Chard (Beta vulgarisL. var. cicla) has antioxidant, antidiabetic, antitumor and hepatoprotective effects. Its protective effects against VPA toxicity have not been fully investigated yet. According to the results of this study, chard (B.vulgarisL. var. cicla) can be used as a dietary food supplement in the epilepsy treatment. The beneficial effect of chard consumption is an important finding in a nutritional point of view as chard contains many significant bioactive constituents for a healthy diet.Publication Metadata only Protective effect of Myrtle (Myrtus communis) on burn induced skin injury(ELSEVIER SCI LTD, 2019) ŞEN, ALİ; Ozcan, Ozan; Ipekci, Hazal; Alev, Burcin; Ustundag, Unsal Veli; Ak, Esin; Sen, Ali; Alturfan, Ebru Emekli; Sener, Goksel; Yarat, Aysen; Cetinel, Sule; Akbay, Tugba TunaliThermal skin burns cause local injury as well as triggers acute systemic inflammation response where the imbalance between oxidative and antioxidative system occurs. As an alternative treatment, various medicinal herbs are used to treat burn injuries in many countries. In this study, the possible protective role of oral or topical Myrtle (Myrtus communis L.) treatment against burn-induced damage was investigated. The dorsum of the Wistar Albino rats was shaved and exposed to 90 degrees C water bath in burn group or 25 degrees C water bath in control group for 10 s under ether anesthesia. Myrtle extract was applied 100 mg/kg/day for 2 days either orally or topically. In skin samples; malondialdehyde and glutathione levels, catalase, superoxide dismutase, nitric oxide and tissue factor activities were determined. Skin tissues were also examined by light microscopy. Severe thermal skin bum injury caused a significant decrease in glutathione level, superoxide dismutase, catalase and tissue factor activities as well as nitric oxide level, which was accompanied with significant increases in skin malondialdehyde level. Myrtle treatment reversed all these biochemical indices except topical Myrtle treated group's nitric oxide level, as well as histopathological alterations, which were induced by thermal trauma. Both oral and topical Myrtle extract treatment was found to have protective role in the bum induced oxidative injury, which may be attributed to the potential antioxidant effect of Myrtle. As a conclusion, Myrtle significantly diminishes burn-induced damage in skin. (C) 2019 Elsevier Ltd and ISBI. All rights reserved.Publication Metadata only Protective Effects of Black Cumin (Nigella sativa) Oil on TNBS-Induced Experimental Colitis in Rats(SPRINGER, 2011) AKBAY, TUĞBA; Isik, F.; Akbay, Tugba Tunali; Yarat, A.; Genc, Z.; Pisiriciler, R.; Caliskan-Ak, E.; Cetinel, S.; Altintas, A.; Sener, G.The pathogenesis and treatment of ulcerative colitis remain poorly understood. The aim of the present study is to investigate the effects of black cumin (Nigella sativa) oil on rats with colitis. Experimental colitis was induced with 1 mL trinitrobenzene sulfonic acid (TNBS) in 40% ethanol by intracolonic administration with 8-cm-long cannula under ether anesthesia to rats in colitis group and colitis + black cumin oil group. Rats in the control group were given saline at the same volume by intracolonic administration. Black cumin oil (BCO, Origo 100% natural Black Cumin Seed Oil, Turkey) was given to colitis + black cumin oil group by oral administration during 3 days, 5 min after colitis induction. Saline was given to control and colitis groups at the same volume by oral administration. At the end of the experiment, macroscopic lesions were scored and the degree of oxidant damage was evaluated by colonic total protein, sialic acid, malondialdehyde, and glutathione levels, collagen content, and tissue factor, superoxide dismutase, and myeloperoxidase activities. Tissues were also examined by histological and cytological analysis. Proinflammatory cytokines [tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-1 beta, and IL-6], lactate dehydrogenase activity, and triglyceride and cholesterol levels were analyzed in blood samples. We found that black cumin oil decreased the proinflammatory cytokines, lactate dehydrogenase, triglyceride, and cholesterol, which were increased in colitis. BCO, by preventing inflammatory status in the blood, partly protected colonic tissue against experimental ulcerative colitis.