Person: YANARTAŞ, ÖMER
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YANARTAŞ
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ÖMER
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Publication Open Access Increased Neutrophil/Lymphocyte Ratio in Patients with Depression is Correlated with the Severity of Depression and Cardiovascular Risk Factors(KOREAN NEUROPSYCHIATRIC ASSOC, 2016) SARI, İBRAHİM; Sunbul, Esra Aydin; Sunbul, Murat; Yanartas, Omer; Cengiz, Fatma; Bozbay, Mehmet; Sari, Ibrahim; Gulec, HuseyinObjective Chronic inflammation is associated with cardiovascular (CV) risk factors and psychiatric disorders. The neutrophil to lymphocyte ratio (NLR) has been investigated as a new biomarker for systemic inflammatory response. The aim of the study is to investigate the relation of NLR with severity of depression and CV risk factors. Methods The study population consisted of 256 patients with depressive disorder. Patients were evaluated with the Hamilton Rating Scale for Depression (HAM-D). Patients were classified into four groups according to their HAM-D score such as mild, moderate, severe, and very severe depression. Patients were also evaluated in terms of CV risk factors. Results Patients with higher HAM-D score had significantly higher NLR levels compared to patients with lower HAM-D score. Correlation analysis revealed that severity of depression was associated with NLR in depressive patients (r=0.333, p<0.001). Patients with one or more CV risk factors have significantly higher NLR levels. Correlation analysis revealed that CV risk factors were associated with NLR in depressive patients (r=0.132, p=0.034). In logistic regression analyses, NLR levels were an independent predictor of severe or very severe depression (odds ratio: 3.02, 95% confidence interval: 1.867-4.884, p<0.001). A NLR of 1.57 or higher predicted severe or very severe depression with a sensitivity of 61.4% and specificity of 61.2%. Conclusion Higher HAM-D scores are associated with higher NLR levels in depressive patients. NLR more than 1.57 was an independent predictor of severe or very severe depression. A simple, cheap white blood cell count may give an idea about the severity of depression.Publication Open Access Increased arterial stiffness parameters in panic disorder patients in long term treatment period(BMC, 2016-12) SARI, İBRAHİM; Yanartas, Omer; Sunbul, Murat; Senkal, Zeynep; Durmus, Erdal; Kivrak, Tarik; Subasi, Nilufer; Karaer, Gulhan; Ergun, Serhat; Sari, Ibrahim; Sayar, KemalBackground: The relationship between mental stress and cardiovascular disease has been shown in several studies. Panic disorder (PD) is also associated with cardiovascular disease due to increased risk of myocardial infarction. The aim of this study is to evaluate the association between arterial stiffness parameters and depression/anxiety scores in patients with PD. Methods: The study population consisted of 25 patients with PD and 25 age-sex-matched healthy controls. Depression and anxiety levels were evaluated by Beck Depression Inventory (BDI) and Beck Anxiety Inventory (BAI), respectively. Determination of arterial stiffness parameters was conducted using a Mobil-O-Graph arteriograph system that detected signals from the brachial artery. Results: While baseline characteristics were similar between two groups, BDI and BAI scores were significantly higher in patients with PD (p < 0.005). The pulse wave velocity (PWV) and Augmentation Index (AIx) were also significantly higher in patients with PD (p = 0.001, p = 0.006). There was a moderate correlation between PWV and AIx with BAI scores (r = 0.442, p = 0.001, r = 0.441, p = 0.001). AIx was also positively correlated with BDI scores (r = 0.415, p = 0.03). Conclusion: We demonstrated a significant relationship between arterial stiffness parameters and anxiety/depression scores in patients with PD who receive antidepressant treatment.Publication Open Access Depression and quality of life in hemodialysis andpredialysis patients in a sample from Turkey(2016-01-01) SAYAR, MUSTAFA KEMAL; YANARTAŞ, ÖMER; DADALI Z., SAYAR M. K. , HARMANKAYA N. Ö. , YANARTAŞ Ö., Türkcan A., AKIN E., Köse S.In this study, we aimed to examine the quality of life, depression, and anxiety in chronic renal failure at the predialysis and hemodialysis stage and groups, to show that depression anxiety start prior to dialysis, and to explore the impact of depression and anxiety on the quality of life of these patients. We included 49 hemodialysis and 50 predialysis (stage IV chronic kidney failure) patients who were followed up at the Bakırkoy Dr. Sadi Konuk Training and Research Hospital‘s Dialysis Unit and Nephrology Outpatient Clinic. Sociodemographic data were obtained from all patients in addition to the Hospital Anxiety and Depression Scale and the MOS 36-Item Short-Form Health Survey (SF-36). Results: No significant differences were found in terms of sociodemographic characteristics of two study groups. No significant differences were found in terms of HADS scores of two study groups SF-36 scores were not significantly different except for pain and physical function subscale scores. Quality of life component scores were found significantly lower in depression risk group based on HADS scores, regardless of renal failure stages. Our findings revealed that the quality of life levels were similar in both predialysis and dialysis patients. Depression and anxiety were determinant of quality of life, regardless of the stage of the kidney disease. Since the quality of life in patients with chronic renal failure was considered to be an important factor that determines mortality and morbidity, the treatment of depression at all stages of the illness is gaining importance. Psychiatric examination, psychoeducation and treatment of depression and anxiety symptoms would facilitate psychosocial adjustment and improve patient‘s coping skills prior to developing end-stage renal failure and lower the mortality and morbidity rates in these patients.Publication Open Access Depression and anxiety have unique contributions to somatic complaints in depression, irritable bowel syndrome and inflammatory bowel diseases(TAYLOR & FRANCIS LTD, 2019-10-02) SAKALLI KANİ, AYŞE; Yanartas, Omer; Kani, Haluk Tarik; Kani, Ayse Sakalli; Akca, Zeynep Nur Demirok; Akca, Erdogdu; Ergun, Serhat; Tezcan, Neslihan; Atug, Ozlen; Imeryuz, Nese; Sayar, KemalOBJECTIVE: In this study we aim to investigate the effects of somatic and related symptoms (SARS), alexithymia, hypochondriasis, anxiety and depression on patients with major depressive disorder, irritable bowel syndrome, inflammatory bowel disease which are the representative diseases of brain gut axis (BGA). METHOD: Sex and age similar groups of participants with major depressive disorder (MDD) (n = 102), irritable bowel syndrome (IBS) (n = 51), inflammatory bowel diseases (IBDs) (n = 54), and control group (n = 67) were included into this study. Depression and IBS were diagnosed according to DSM-5 and ROME 4 criteria, respectively. IBDs were established according to endoscopic, histological, and radiographic investigations. In all participants, somatic and related symptoms were evaluated by self-report scales including Bradford Somatic Inventory (BSI), Beck Depression Inventory (BDI), Beck Anxiety Inventory (BAI), Whiteley Index (WI), The 20-item Toronto Alexithymia Scale (TAS-20), Somatosensory Amplification Scale (SAS). RESULTS: BSI, BDI, BAI, WI, TAS-20 and SAS scores were found to be highest in patients with MDD; scores of patients with IBS and IBDs were similar but higher than the control group. Gastrointestinal somatic symptoms including nausea, stomach burning, abdominal ache and stomach swelling were observed in more than half of the patients with MDD. The most common extra-intestinal somatic symptoms were, headache and neck pain and/or tension, and leg pain in IBS patients. However leg pain, weakness and lack of energy, and neck pain/tension were highest in IBDs patients. While the strongest correlation determined was between the BSI and anxiety scores in MDD (p<.001, r = .688) and IBS group; (p<.001, r = .51), in IBDs patients, BSI scores were more significantly correlated with depressive scores instead of anxiety (p<.001, r = .712 vs. r = .705, p<.001). CONCLUSION: Our study demonstrates that SARS are commonly observed in the representative diseases of BGA. Extra-intestinal somatic symptoms are common in IBS, and IBDs, and also gastrointestinal somatic symptoms are common in patients with MDD. Assessment of somatic and related symptoms is quite important in the context of BGA.