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Author: ILGIN, CAN × Start date: 2018 ×

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    PublicationOpen Access
    Autism Awareness Scale for Security Officers Working in Hospitals: A Study of Validity and Reliability
    (MARMARA UNIV, INST HEALTH SCIENCES, 2020-10-26) SARISALTIK, ALİCAN; Karavus, Melda; Hidiroglu, Seyhan; Sarisaltik, Alican; Ilgin, Can; Yuksel, Gulsum Hatice; Seker, Abdullah Omer; Kumru, Pinar; Save, Dilsad; Luleci, Nimet Emel
    Objective: The purpose of this study was to evaluate the knowledge and awareness toward autism among security officers working in hospitals and to explore the validity and reliability of the Autism Awareness Scale for Security Officers (AASSO) developed by the researchers. Methods: This methodological study was conducted at two Government Training and Research Hospitals in Istanbul, Turkey. A total of 135 security officers were included in the study and the data were obtained between February and April 2019. The AASSO is a 4-point Likert type scale and consists of 20 items. The factor structure of the scale was extracted by performing exploratory factor analysis. Results: Most of the participants were male (n=79; 58.5%) and high school graduates (n=86; 67.7%). Participants considered autism mostly as a kind of mental retardation (n=69; 51.9%), followed by social interaction problem (n=24; 18.0%). The AASSO reduces autism awareness into 3 factors ('Coming across', 'Communication' and `Interaction with the environment'), with eigenvalues ranging from 9.417 to 1.201 and explained 65.45% of all variance. Cronbach's alpha values for the AASSO was 0.936 and ranged from 0.921 to 0.809 for the subscales. Conclusion: According to these results AASSO is a valid and reliable scale. The consequence of further studies especially conducted on non-healthcare professionals of hospitals should be establishing autism-friendly hospitals.
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    PublicationMetadata only
    Metagenomic analysis of black-stained plaques in permanent dentition
    (PERGAMON-ELSEVIER SCIENCE LTD, 2021) ILGIN, CAN; Celik, Zeynep Ceren; Cakiris, Aris; Yanikoglu, Funda; Abaci, Neslihan; Ekmekci, Sema Sirma; Ilgin, Can; Celik, Halil; Tagtekin, Dilek
    Objectives: We aimed to determine the aetiologic agent responsible for black staining of permanent dentition using next-generation sequencing and determine the relationship between caries and black stains. Materials and methods: A total of 52 systemically healthy patients with black-stained and caries-free (n = 13), black-stained and carious (n = 13), black stain-free and caries-free (n = 13), and black stain-free and carious (n = 13) teeth were enrolled in the study. The International Caries Detection and Assessment System (ICDAS II) was used for caries classification. Between 08:00 and 10:00, supragingival plaque samples were collected after a minimum of 8-12 h of accumulation and DNA samples were isolated. The samples were processed using the ZymoBIOMICS (TM) Service. Bioinformatics analysis was performed using mothur at usegalaxy.org. Data were analysed statistically using the Pearson chi-square and Fisher tests. Results: The number of caries-free teeth (ICDAS 0, 1, and 2) was significantly higher in patients with black stains (p = 0.007).Capnocytophaga (4.8 %), Corynebacterium (3.9 %), and Neisseria (5.4 %) species were the most abundant among all black-stained plaques (carious and caries-free) (p < 0.05). Capnocytophaga (10.8 %), Cardiobacterium (3.6 %), and Rothia (1.72 %) species were detected in the black-stained plaques of caries-free patients (p < 0.05). Conclusion: This study is one of the first studies examining the microbial composition of dental plaques with black staining in carious and caries-free adult patients using next generation sequencing technology. In the presence of black staining, plaques have an ultimate complex microbial structure. A lower caries burden was noted in the presence of black staining.
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    PublicationOpen Access
    Use of HCRP and Cystatin C as inflammation markers in the follow-up of kidney functions in obesity Enflamatuvar belirteç olarak HCRP ve Sistatin C’nin obezitede böbrek fonksiyonları izleminde kullanılması
    (2022-01-01) ILGIN, CAN; Çeçen S., Çağlayik D. Y. , ILGIN C.
    © 2022. Turk Hijyen ve Deneysel Biyoloji Dergisi. All Rights Reserved.Objective: Determination of glomerular filtration rate is essential for kidney functions in obesity. Creatinine and cystatin C are used to determine glomerular filtration rate. Cystatin-c increases with the increase of adipose tissue. The study investigates the use of cystatin C in calculating the glomerular filtration rate in obese individuals. Methods: One hundred thirteen obese women were used in the study. The height of the patients was measured barefoot on a flat surface. A whole-body analysis was performed by bioimpedance device (Tanita-BC418), and body weight, body mass index (BMI), fat percentage, fat mass, fat-free mass were detected. Biochemical data were evaluated retrospectively. CKD-EPI-GFR (Chronic Kidney Disease Epidemiology Collaboration equation glomerular filtration rate), GFRepi-cr (creatinine-GFR), GFR-epi-cysc (cystatin C-GFR) and GFR-epi-cr-cysc (combined-GFR) values were calculated from the measured cystatin-c and creatinine values. Results: We found that GFR-epi-cr decreased with age and BMI, increased with height, GFR-epi-cysc decreased with age, BMI, fat percentage, fat mass, increased significantly with height, GFR-epi-cr-cysc decreased with age, BMI, fat percentage, fat mass. GFR-epi-cr, GFR-epi-cysc, GFR-epi-cr-cysc decreased with HCRP (High-C-reactif protein). Creatinine increased with age and decreased with GFR-epi-cr, GFR-epi-cysc, GFR-epi-cr-cysc. Cystatin-c increased with age, body weight, BMI, fat percentage, fat mass, and decreased GFR-epi-cr, GFR-epi-cysc, GFR-epi-crcysc. Conclusion: Cystatin C can pass through kidney glomeruli easily and used in GFR calculation. We found that while cystatin-c increases with increased adipose tissue in obese individuals, GFR-epi–cysc ve GFRepi-cr-cysc decreased. As well, HCRP increased with the fat percentage and fat mass. These results are essential in terms of inflammation, which is evident with the increase in adipose tissue, affects kidney functions in obese individuals. Our study is essential in raising awareness about GFR calculation and parameters used in the follow-up of kidney functions in obese individuals.Our study shows that to use of cystatin Cmay give wrong results to calculate GFR and follow up of kidney functions in obese individuals.
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    PublicationOpen Access
    The Factors Associated with Mothers' Preventive Measures Against Home Accidents: A Descriptive Study from Istanbul, Turkey
    (MARMARA UNIV, INST HEALTH SCIENCES, 2019-06-30) ILGIN, CAN; Bayram, Tevfik; Ilgin, Can; Kulbay, Hayriye; Tozakoglu, Batuhan; Karaduman, Ilker; Colak, Burkay Cagan; Save, Dilsad
    Objective: One of the most common causes of death among children in Turkey is accidents, and of this, 18-25% caused by home accidents. This study aims to identify the factors associated with safety measures against home accidents, that are taken by mothers who have children between 0-6 years of age. Methods: This descriptive study was conducted among the mothers who admitted to three Family Health Centers in Istanbul, Turkey, in 2017. The data was collected with a questionnaire including The Scale for Mother's identification of Safety Measures Against Home Accidents for Children of 0-6 Years Age Group. The data was analyzed with SPSS program using Chi square, Mann Whitney-U and Spearman correlation tests (p<0,05 considered significant). 224 mothers participated in this study. Results: The most frequent home accidents were falling (48.9%), finger jam (36.6%) and crashing (30.6%). There was a weak positive correlation between the scale score and family's income (p=0.039; r=0.157); and a weak negative correlation between the scale score and child's age (p=0.001; r=-0.331). There was no association between education level of parents and safety measures. However, the scale scores were significantly higher among those who have specifically been educated about home accidents compared to those who haven't (p=0.013). Conclusion: The current education program may not be sufficient to prevent home accidents. We believe that specific courses about home accidents and safety measures are needed; even if these courses can be integrated to secondary school or university curricula it can be more beneficial.
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    PublicationOpen Access
    Evaluation of direct 16S rRNA PCR from clinical samples for bacterial detection in normally sterile body sites
    (2019-11-30) ILGIN, CAN; Satilmis, Serife; Ulger Toprak, Nurver; Ilgın, Can; Soyletir, Guner
    Introduction: In addition to antibiotic treatment, slow-growing and non-cultivable bacteria can lead to false-negative results for sterile body site infections. In this study, we investigated the efficacy of 16S rRNA polymerase chain reaction (PCR) for such infections. Methodology: Following routine culture procedures, 16S ribosomal RNA (16S rRNA) PCR was performed for samples collected from sterile body sites between July 2017and September 2018. The samples were separated into two groups for likely (group 1) and unlikely infections (group 2) based on clinical and laboratory findings, as well as clinician opinion. Sequence analysis was performed for PCR-positive samples using 16S rRNA primers. Mixed chromatograms were analyzed with the RipSeq Mixed program, and Stata 15.1 was used for statistical analysis. Results: Eighty-seven of 139 samples collected from 116 patients were placed in group 1, and 52 were placed in group 2. Compared with culture as the reference method, the sensitivity, specificity, positive predictive value, and negative predictive value for 16S rRNA PCR were 89.8%, 85.6%, 77.2%, and 93.9%, respectively. 16S rRNA PCR identified infections in 13 culture-negative samples. Among these, three had Bartonella quintana, Mycoplasma salivarium, and Mycobacterium avium complex infections, which cannot be detected with commercial multiplex PCR kits. Conclusions: Our study demonstrates that 16S rRNA PCR is effective for the diagnosis of sterile body site infections, especially for cases of meningitis and infective endocarditis where routine cultures fail.
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    PublicationOpen Access
    Evaluation of sarcopenia in patients with hyperthyroidism
    (2022-12-01) TUFAN ÇİNÇİN, ASLI; ENGİN, EBRU; ELBASAN, ONUR; ILGIN, CAN; TUFAN ÇİNÇİN A., Engin E., Elbasan O., Durmus N. S., Can B., Ilgin C., Can B.
    Background and aim: Sarcopenia is a generalized skeletal muscle disease and thyroid hormones have regulatory effects on skeletal muscle metabolism. This study aims to evaluate the association between hyperthyroidism and sarcopenia. Methods: Thirteen patients with overt hyperthyroidism (OH), 13 patients with subclinical hyperthyroidism (SH) and 30 healthy volunteers were included. OH was defined as serum thyroid-stimulating hormone (TSH) 1.12 ng/dL and/or free T3 (fT3) >4.37 ng/L; while SH was defined as TSH <0.34 when fT4 and fT3 were within the normal reference range (0.61-1.12 ng/dL for fT4; 2.6-4.37 ng/L for fT3). Handgrip strength (HGS) measurement and chair stand test were performed for muscle strength, while skeletal muscle mass index measurement with bioelectrical impedance analysis and calf circumference (CC) measurement were performed for muscle mass evaluation. Results: The median age was 44.9 (21-76), and 16 (61.5%) were female. HGS and CC were found to be significantly lower in the OH and SH groups than in the control group (p=0.007; p=0.008, respectively). Sarcopenia was more common in the OH and SH groups than in the control group (p=0.007), and the risk of sarcopenia was higher in the OH group than in the SH group (OR: 2.44, 95% CI: 0.26-31.87). In hyperthyroid patients, a high fT4 increased the possibility of sarcopenia (OR: 6.0 95% CI: 0.59-79.23). Conclusions: Sarcopenia is significantly more common in patients with hyperthyroidism.
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    PublicationMetadata only
    Capillary microarchitectural changes in Cushing's syndrome
    (Academic Press Inc., 2022) ILGIN, CAN; Apaydin T., Yalcinkaya Y., Ilgin C., Gogas Yavuz D.
    Purpose: Macrovascular alterations are prominent in Cushing's syndrome (CS). Microvascular abnormalities are yet to be established. This cross-sectional observational study aimed to evaluate microvascular changes in nailfold capillaries and their association with disease status and carotid intima-media thickness (CIMT) as a marker of atherosclerosis. Methods: A total of 70 patients with CS [46 (65.7%) ACTH-dependent pituitary adenoma and 24 (34.3%) adrenocortical adenomas] and 100 healthy controls were enrolled. The microvascular structure was evaluated using nailfold video-capillaroscopy (NVC). Results: The median number of capillaries was less [10 mm (IQR: 2, min-max:7–14) vs. 11 mm (IQR: 2, min-max:9–19) (p < 0.001)], the median limb diameter and capillary width were wider in the CS group than in the controls (p = 0.016 and p = 0.002, respectively). Microhemorrhages within limited areas were more frequent in the CS group than in the controls (p = 0.046). Observed capillary changes were similar among the patients with CS with remission or active disease. CIMT levels were higher in the CS group than in the controls and similar in subjects with active disease and remission. Univariate logistic regression analyses revealed that the number of capillaries and capillary widths were associated with body mass index (BMI), the presence of type 2 diabetes mellitus, HbA1c, and CIMT. Conclusion: Morphologic alterations present similarly in nailfold capillaries in subjects with CS regardless of disease status, resembling changes in chronic atherosclerotic diseases. Microvascular changes in nailfold capillaries measured using NVC can be used as a marker in the assessment of cardiovascular risk in patients with CS. © 2022 Elsevier Inc.
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    PublicationOpen Access
    Regional pulmonary oxygen saturations immediately after birth
    (2022-03-01) GÜLCAN KERSİN, SİNEM; ILGIN, CAN; ÖZEK, EREN; BİLGEN, HÜLYA SELVA; GÜLCAN KERSİN S., Yasa B., Cetinkaya M., ILGIN C., ÖZEK E., BİLGEN H. S.
    Background: Partial oxygen saturation (SpO2) increases within minutes during transition from the intrauterine to extrauterine life. This study aims to determine the postnatal course of pulmonary regional oxygen saturation (rSO2) measured by Near-Infrared Spectroscopy (NIRS). Methods: We conducted an observational study at the delivery room in infants above 35 weeks of gestation who did not need resuscitation and did not develop respiratory distress. Preductal pulse oximetry (Covidien NellcorTM) and right pulmonary apex oxygen saturation (raSO2) and basal oxygen saturation (rbSO2) (Covidien INVOSTM) were measured, starting from the postnatal third minute of life, until the 15th minute. The correlations between SpO2 and pulmonary rSO2 were analyzed. Results: Of the 110 infants included in the study, 87 were term and 23 were late preterms. The gestational age and birth weight were 38.5 ± 1.36 weeks and 3285 ± 508 g, respectively. Median (5th–95th percentile) raSO2 and rbSO2 were 79% (58–95%) and 78% (46–95%) at the third minute, respectively. The rSO2 values measured from both sides increased and reached a steady-state around postnatal 9 min, similar to SpO2 values. The pulmonary NIRS values were significantly higher for babies born by C-Section compared to babies born by vaginal delivery (p < 0.05). Conclusion: We found that rSO2 measurements increased within minutes in the postnatal period in late preterm and term babies without respiratory distress and reached a plateau at the postnatal 9th minute. The normal values obtained from this preliminary study may be used to predict the prognosis of cases with respiratory distress.
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    Predictors for the risk and severity of post-thrombotic syndrome in vascular Behcet's disease
    (ELSEVIER, 2021) ILGIN, CAN; Aksoy, Aysun; Colak, Seda; Yagiz, Burcu; Coskun, Belkis Nihan; Omma, Ahmet; Yildiz, Yasin; Sari, Alper; Atas, Nuh; Ilgin, Can; Karadag, Omer; Erden, Abdulsamet; Dalkilic, Ediz; Bolca, Naile; Ergelen, Rabia; Onur, Mehmet Ruhi; Direskeneli, Haner; Alibaz-Oner, Fatma
    Objective: Deep vein thrombosis (DVT) of the lower extremities is the most common form of vascular involvement in Behcet disease (BD), frequently leading to post-thrombotic syndrome (PTS) as a disabling complication. We have described the clinical characteristics and predictors of PTS presence among patients with BD and lower extremity DVT. We also used venous Doppler ultrasound (US) examinations in our assessment. Methods: Patients with BD (n = 205; 166 men, 39 women; age 39 6 9.5 years) and a history of DVT were investigated. The Villalta scale was used to assess the presence and severity of PTS. Doppler US examinations were performed within 1 week of the clinical evaluation. The total number of vessels with reflux, thrombi, recanalization, and collateral vessels were calculated. Results: Of the 205 patients with BD, 62% had had PTS and 18% had had severe PTS. Patients with PTS had had greater reflux (P = .054) and thrombosis (P = .02) scores compared with patients without PTS. Treatment with anticoagulation (AC), immunosuppressive (IS) therapy, or AC combined with IS drugs did not affect the occurrence of PTS. However, patients treated with IS therapy, with or without AC drugs, had a decreased incidence of severe PTS compared with the AC-only group (P = .017). Patients treated with AC plus IS agents also had increased collateral scores compared with patients treated with only IS drugs. Interferon-a use seemed to provide better recanalization scores compared with azathioprine only (1.0 [range, 0-14] vs 2.5 [range, 0-10]; P = .010). Conclusions: Patients with BD and DVT have a high risk of developing severe PTS. IS treatment decreases the development of severe PTS. AC therapy might influence the course of PTS by increasing the collateral scores, and the use of interferon-a also increased recanalization scores. Routine assessment with Doppler US examinations could be helpful in the prediction of severe PTS. (J Vasc Surg Venous Lymphat Disord 2021;9:1451-9.)
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    PublicationOpen Access
    Effect of denosumab treatment on bone mineral density and bone turnover markers in osteoporotic patients: real-life experience 2-year follow-up
    (2022-12-01) DİNÇER YAZAN, CEYDA; BUĞDAYCI, ONUR; ILGIN, CAN; YAVUZ, DİLEK; DİNÇER YAZAN C., BUĞDAYCI O., ILGIN C., YAVUZ D.
    Summary Denosumab leads to improvements in BMD levels and is a well-tolerated agent according to results of randomized controlled studies but results in real-life setting are important to evaluate drug adherence and real-life efciency. In this study, we present the results of 305 patients that were treated with denosumab in our clinic. Introduction The long-term efcacy of anti-osteoclastic drugs in treatment of osteoporosis is well known. Denosumab, a novel human monoclonal antibody, is an anti-osteoclastic agent that has been shown to lead to reductions in vertebral, nonvertebral, and hip fracture risk in randomized and observational studies. Real-life data of this agent is increasing. In this study, we presented our real-life data about the 2-year follow-up of patients under denosumab treatment. Methods Osteoporotic patients who were treated with at least one denosumab injection between 2014 and 2020 years were included. Clinical and demographic data, bone turnover markers, and radiological reports (bone mineral densitometry (BMD), vertebral x-ray) were obtained from patient fles retrospectively. Results A total of 305 patients (f/m: 275/30, 68.1±11.05 years) were included. The median injection number was 4 (1–10). Two hundred seventy-three patients (89.8%) were persistent on treatment at the 12th month; 175 patients (57.3%) were persistent at 24th month. Sixty-eight patients (22%) were not using denosumab anymore, 55 of the patients were not continuing by doctor desicion and 13 were not continuing due to patient-related causes. Median BMD levels signifcantly increased from 0.809 (0.2–1.601, IQR: 0.136) to 0.861 (0.517–1.607, IQR: 0.14) in L1–L4 and from 0.702 (0.349–0.997, IQR: 0.125) to 0.745 (0.508–1.008, IQR: 0.137) in femur area at the 24th month of treatment. An improvement of 8.04% in L1–L4 BMD and 4.5% in femur neck BMD levels at the 24th month of treatment was observed. There was a signifcant decrease in bone turnover markers at the 24th month of treatment. Conclusion In our group of patients under denosumab treatment, 53% of persistence was found at 24 months and associated with improvement in BMD levels without any signifcant side efects except one case with urticarial reaction. Denosumab leads to improvements in BMD levels and is a well-tolerated agent in a real-life setting comparable to results of randomized controlled studies in patients with diferent comorbidities.