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Author: TAĞTEKİN, DİLEK × Start date: 2018 ×

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Now showing 1 - 3 of 3
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    Metagenomic analysis of black-stained plaques in permanent dentition
    (PERGAMON-ELSEVIER SCIENCE LTD, 2021) ILGIN, CAN; Celik, Zeynep Ceren; Cakiris, Aris; Yanikoglu, Funda; Abaci, Neslihan; Ekmekci, Sema Sirma; Ilgin, Can; Celik, Halil; Tagtekin, Dilek
    Objectives: We aimed to determine the aetiologic agent responsible for black staining of permanent dentition using next-generation sequencing and determine the relationship between caries and black stains. Materials and methods: A total of 52 systemically healthy patients with black-stained and caries-free (n = 13), black-stained and carious (n = 13), black stain-free and caries-free (n = 13), and black stain-free and carious (n = 13) teeth were enrolled in the study. The International Caries Detection and Assessment System (ICDAS II) was used for caries classification. Between 08:00 and 10:00, supragingival plaque samples were collected after a minimum of 8-12 h of accumulation and DNA samples were isolated. The samples were processed using the ZymoBIOMICS (TM) Service. Bioinformatics analysis was performed using mothur at usegalaxy.org. Data were analysed statistically using the Pearson chi-square and Fisher tests. Results: The number of caries-free teeth (ICDAS 0, 1, and 2) was significantly higher in patients with black stains (p = 0.007).Capnocytophaga (4.8 %), Corynebacterium (3.9 %), and Neisseria (5.4 %) species were the most abundant among all black-stained plaques (carious and caries-free) (p < 0.05). Capnocytophaga (10.8 %), Cardiobacterium (3.6 %), and Rothia (1.72 %) species were detected in the black-stained plaques of caries-free patients (p < 0.05). Conclusion: This study is one of the first studies examining the microbial composition of dental plaques with black staining in carious and caries-free adult patients using next generation sequencing technology. In the presence of black staining, plaques have an ultimate complex microbial structure. A lower caries burden was noted in the presence of black staining.
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    The complex microbiome of caries-active and caries-free supragingival plaques in permanent dentition
    (Wolters Kluwer Medknow Publications, 2021) ILGIN, CAN; Celik Z., Cakiris A., Abaci N., Yaniikoglu F., Ilgin C., Ekmekci S., Celik H., Tagtekin D.
    Background and Aim: Dental caries is one of the most common diseases seen in the oral cavity in all periods of deciduous, mixed, and permanent dentition. A comprehensive study of the oral microbiome is required to understand its polymicrobial etiology. The aim of this study was to reveal the plaque microbiome of caries-active and caries-free adults. Materials and Methods: A total of 52 samples were collected from 26 caries-active patients and 26 caries-free controls. Dental supragingival plaque samples were collected from each subject and the bacterial 16S rDNA, expanded V3-V4 region, was amplified using next generation sequencing. Results: The core microbiome was defined with 235 shared bacteria in genus level, and among all microbiome 14.8% of all bacteria showed significant difference (P < 0.05). The bacteria responsible of caries may be listed as Anaeroglobus, Atopobium, Bifidobacterium, Centipeda, Cryptobacterium, Desulfobulbus, Filifactor, Howardella, Lactobacillus, Leptotrichiaceae (unclassified), Megasphaera, Mycoplasma, Olsenella, Phocaeicola, Propionibacterium, Pseudoramibacter, Scardovia, Schwartzia, Treponema, and Veillonellaceae (unclassified). Conclusion: The present study provides comprehensive knowledge of the microbiological etiology of caries in permanent dentition. © 2021 Wolters Kluwer Medknow Publications. All rights reserved.
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    The Effect of Dental Paste with Herbal Content on Remineralization and the Imaging with Fluorescent Technique in Teeth with White Spot Lesion
    (MARMARA UNIV, INST HEALTH SCIENCES, 2021-04-04) ILGIN, CAN; Kiristioglu, Zeynep Beyza; Yanikoglu, Funda; Alkan, Elif; Tagtekin, Dilek; Gocmen, Gulcin Bilgin; Ilgin, Can
    Objective: To evaluate the effect of Gumgumix herbal toothpaste on remineralization of white spot lesions with a laser fluorescent system called FluoreCam. It is a pilot study. Methods: The FluoreCam system was used for the fluorescence imaging of the fifteen teeth with white spot lesions. During the study, the patients continued to use the previously owned toothpastes, addition to Gumgumix. Gumgumix was applied on the lesion area with a finger pressure twice a day and was not rinsed mouth after, only a limited spit and was prevented from taking any fluid during 30 minutes. The Compare option in the FluoreCam system was used to differentiate the situation before and after the use of the paste; if the marked area were yellow No Change; blue Sound Surface; green Improving; light blue Mild Improving and red meant Worsening. Results: Of the 13 lesions that were Suspect Surface initially, 46% were identified as Mild Improving, 7% as Moderate Worsening, 30% as No Change, and 15% as Sound Surface. Two of the white spot lesions were recovered totally as 100%. Conclusion: After use of Gumgumix for one week, remineralization was observed on teeth with white spot lesion. The white spot lesions on two teeth were totally healed.