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ILGIN, CAN

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ILGIN

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2018 - 20194
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    PublicationOpen Access
    The Factors Associated with Mothers' Preventive Measures Against Home Accidents: A Descriptive Study from Istanbul, Turkey
    (MARMARA UNIV, INST HEALTH SCIENCES, 2019-06-30) ILGIN, CAN; Bayram, Tevfik; Ilgin, Can; Kulbay, Hayriye; Tozakoglu, Batuhan; Karaduman, Ilker; Colak, Burkay Cagan; Save, Dilsad
    Objective: One of the most common causes of death among children in Turkey is accidents, and of this, 18-25% caused by home accidents. This study aims to identify the factors associated with safety measures against home accidents, that are taken by mothers who have children between 0-6 years of age. Methods: This descriptive study was conducted among the mothers who admitted to three Family Health Centers in Istanbul, Turkey, in 2017. The data was collected with a questionnaire including The Scale for Mother's identification of Safety Measures Against Home Accidents for Children of 0-6 Years Age Group. The data was analyzed with SPSS program using Chi square, Mann Whitney-U and Spearman correlation tests (p<0,05 considered significant). 224 mothers participated in this study. Results: The most frequent home accidents were falling (48.9%), finger jam (36.6%) and crashing (30.6%). There was a weak positive correlation between the scale score and family's income (p=0.039; r=0.157); and a weak negative correlation between the scale score and child's age (p=0.001; r=-0.331). There was no association between education level of parents and safety measures. However, the scale scores were significantly higher among those who have specifically been educated about home accidents compared to those who haven't (p=0.013). Conclusion: The current education program may not be sufficient to prevent home accidents. We believe that specific courses about home accidents and safety measures are needed; even if these courses can be integrated to secondary school or university curricula it can be more beneficial.
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    PublicationOpen Access
    Evaluation of direct 16S rRNA PCR from clinical samples for bacterial detection in normally sterile body sites
    (2019-11-30) ILGIN, CAN; Satilmis, Serife; Ulger Toprak, Nurver; Ilgın, Can; Soyletir, Guner
    Introduction: In addition to antibiotic treatment, slow-growing and non-cultivable bacteria can lead to false-negative results for sterile body site infections. In this study, we investigated the efficacy of 16S rRNA polymerase chain reaction (PCR) for such infections. Methodology: Following routine culture procedures, 16S ribosomal RNA (16S rRNA) PCR was performed for samples collected from sterile body sites between July 2017and September 2018. The samples were separated into two groups for likely (group 1) and unlikely infections (group 2) based on clinical and laboratory findings, as well as clinician opinion. Sequence analysis was performed for PCR-positive samples using 16S rRNA primers. Mixed chromatograms were analyzed with the RipSeq Mixed program, and Stata 15.1 was used for statistical analysis. Results: Eighty-seven of 139 samples collected from 116 patients were placed in group 1, and 52 were placed in group 2. Compared with culture as the reference method, the sensitivity, specificity, positive predictive value, and negative predictive value for 16S rRNA PCR were 89.8%, 85.6%, 77.2%, and 93.9%, respectively. 16S rRNA PCR identified infections in 13 culture-negative samples. Among these, three had Bartonella quintana, Mycoplasma salivarium, and Mycobacterium avium complex infections, which cannot be detected with commercial multiplex PCR kits. Conclusions: Our study demonstrates that 16S rRNA PCR is effective for the diagnosis of sterile body site infections, especially for cases of meningitis and infective endocarditis where routine cultures fail.
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    The Factors Affecting the Awareness about Transplantation and Decision of Organ Donation in Istanbul, Turkey
    (LIPPINCOTT WILLIAMS & WILKINS, 2018) ILGIN, CAN; Cevik, Ali; Ilgin, Can; Erdogan, Eren; Ardali, Gulay; Cevik, Yusuf; Birtan, Deniz; Dulundu, Ender
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    PublicationOpen Access
    Extracellular Vesicles in Psychiatry Research in the Context of RDoC Criteria
    (KOREAN NEUROPSYCHIATRIC ASSOC, 2018-11-25) TOPUZOĞLU, AHMET; Ilgin, Can; Topuzoglu, Ahmet
    The analysis of extracellular vesicles has been accelerated because of the technological advancements in omics methods in recent decades. Extracellular vesicles provide multifaceted information regarding the functional status of the cells. This information would be critical in case of central nervous system cells, which are confined in a relatively sealed biological compartment. This obstacle is more dramatic in psychiatric disorders since their diagnosis primarily depend on the symptoms and signs of the patients. In this paper, we reviewed this rapidly advancing field by discussing definition of extracellular vesicles, their biogenesis and potential use as clinical biomarkers. Then we focused on their potential use in psychiatric disorders in the context of diagnosis and treatment of these disorders. Finally, we tried to combine the RDoC (Research Domain Criteria) with the use of extracellular vesicles in psychiatry research and practice. This review may offer new insights in both basic and translational research focusing on psychiatric