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BİNGÖL ÖZAKPINAR, ÖZLEM

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BİNGÖL ÖZAKPINAR

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ÖZLEM

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2015 - 20162
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Author: TETİK, ŞERMİN × Subject: inflammation ×

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    Association between the growth arrest-specific 6 (Gas6) gene polymorphism c.834+7G > A and preeclampsia
    (TAYLOR & FRANCIS LTD, 2016) BİNGÖL ÖZAKPINAR, ÖZLEM; Ozakpinar, Ozlem Bingol; Sahin, Sadik; Verimli, Nihan; Simsek, Gulhayat Golbasi; Maurer, Anne-Marie; Eroglu, Mustafa; Tetik, Sermin; Uras, Fikriye
    Objective: Preeclampsia (PE) is a hypertensive disease of pregnancy complicating 2-8% of all pregnancies. The exact pathophysiology still remains unknown. Growth arrest-specific 6 (Gas6) is a member of the vitamin K-dependent protein family and it has been suggested as a novel atherothrombotic risk factor with anti-angiogenic and pro-atherogenic properties. The goal of the our study was to investigate the relationships between the c.834+7G>A polymorphism of GAS6, plasma Gas6 levels and PE.Methods: A total of 150 women, including 82 preeclamptic pregnant women and 68 normotensive pregnant (NP) women, were recruited in the current study. Blood samples were taken from all participitants. Plasma Gas6 levels measured by an enzyme-linked immunosorbent assay. GAS6 polymorphism was determined using a PCR-RFLP method.Results: The plasma Gas6 levels of preeclamptic patients were significantly lower than those of NP women (8.653.70ng/ml and 10.89 +/- 4.23ng/ml respectively, p<0.001). The GG genotype was the most prevalent, and the risk of PE was 3.5-fold higher in pregnant women with GG genotype compared to woman with AA genotype (p<0.01). The A allele was less frequent in preeclamptic patients than in control subjects (OR=2.118, 95% CI=1.330-3.371, p<0.001).Conclusions: Our results suggest that GAS6 c.834+7G>A polymorphism may have a pivotal role in the pathogenesis of PE suggesting that the A allele has a protective role for PE.
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    The impact of platelet functions and inflammatory status on the severity of preeclampsia
    (TAYLOR & FRANCIS LTD, 2015) BİNGÖL ÖZAKPINAR, ÖZLEM; Sahin, Sadik; Ozakpinar, Ozlem Bingol; Eroglu, Mustafa; Tulunay, Aysin; Ciraci, Enver; Uras, Fikriye; Tetik, Sermin
    Objective: To find out whether there is a correlation between the extent of platelet activation and inflammation and the severity of preeclampsia (PE) in the third trimester of pregnancy. Methods: Forty-one women with PE (n = 23 severe, n = 18 mild) and 80 normotensive pregnant (NP) women were included in the study. Their blood samples were obtained and interleukin (IL)-8 and IL-10 levels measured by an enzyme-linked immunosorbent assay. Basal CD61 and CD62P expressions on CD41-positive platelets were analyzed with the use of flow-cytometry. Platelet aggregation was induced by adenosine diphosphate and determined by aggregometry. Results: CD62P expression was increased in severely preeclamptic women, and the platelet aggregation was decreased in both mildly and severely preeclamptic women in comparison with NP women. However, CD61 expression was similar among the groups. An enhanced inflammatory response was seen in severely preeclamptic women demonstrated by increased levels of IL-8 and decreased levels of IL-10. However, the intensity of platelet activation did not correlate directly with the change in plasma levels of IL-8 and IL-10 in preeclamptic women. Conclusions: Platelets may have a role in the inflammatory response in PE. However, the severity of inflammation is found to be independent from the intensity of platelet activation in preeclamptic women. This seems to be related to mechanisms causing alterations of cytokine levels such as IL-8 and IL-10, rather than platelet activation.