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YARAT, AYŞEN

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Author: ŞENER, GÖKSEL × Has files: true ×

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Now showing 1 - 4 of 4
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    PublicationOpen Access
    Effects of Exercise and Calorie Restriction on Brain_x000D_ and Testis in Natural Aging Model
    (2021-04-25) YARAT, AYŞEN; Umay HAKGÜDER;Hazal İPEKÇİ;Tuğba TUNALI AKBAY;Ayşen YARAT;Ebru Emekli ALTURFAN;Ünsal Veli ÜSTÜNDAĞ;Burçin ALEV;Nevin GENC KAHRAMAN;Reyhan ÖZÇELİK;Göksel ŞENER
    The aim of our study was to examine the effects of exercise and calorie_x000D_ restriction on various tissue damage and antioxidant parameters_x000D_ in the brain and testis of rats in a natural aging model. For this_x000D_ purpose, male Sprague-Dawley rats were the control group (C),_x000D_ the elderly (A), the elderly with calorie restriction (ACR), the elderly_x000D_ who were exercised (AE) and the elderly who were exercised with_x000D_ calorie restriction (ACRE), they were divided into 5 groups. The control_x000D_ group was composed of three-month-old animals. The other_x000D_ group consisted of 15-month-old rats. Exercise and calorie restriction_x000D_ were applied for 6 weeks. At the end of the experiment, lipid_x000D_ peroxidation (LPO), nitric oxide (NO), glutathione (GSH) levels and_x000D_ superoxide dismutase (SOD), catalase (CAT), glutathione-S-transferase_x000D_ (GST) and tissue factor (TF) were determined in brain and_x000D_ testicular tissues homogenates. As a result of the study, the A_x000D_ group’s brain and testis LPO, NO levels and TF activity increased,_x000D_ GSH levels and SOD, CAT and GST activities decreased, when compared_x000D_ to the C group. As a result of our study, an increase in oxidant_x000D_ damage was observed with TF activity in the brain and testis in the_x000D_ natural aging model, and positive effects of exercise and calorie_x000D_ restriction on the antioxidant levels in the brain were determined,_x000D_ especially in aging.
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    PublicationOpen Access
    Protective effects ofGinkgo biloba extract against mercury(II)-induced cardiovascular oxidative damage in rats
    (2007-01) YARAT, AYŞEN; Tunali-Akbay, Tugba; Sener, Goksel; Salvarli, Hanife; Sehirli, Ozer; Yarat, Aysen
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    PublicationOpen Access
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    PublicationOpen Access
    Brain in metabolic syndrome model: The effect of exercises and caloric restriction
    (2022-01-01) AKBAY, TUĞBA; ALTURFAN, EBRU IŞIK; ŞENER, GÖKSEL; YARAT, AYŞEN; Alev-Tuzuner B., Genc-Kahraman N., Ipekci H., Ustundag U. V. , AKBAY T., ALTURFAN E. I. , Sener G., YARAT A.
    © 2022 Marmara University Press.Caloric restriction (CR) and exercise (EX) have impacts on improving metabolic risk factors. This study aimed to investigate the changes in the brain after EX and/or CR in metabolic syndrome (MeS) induced by a high fructose diet in rats. Sprague-Dawley male rats were divided into five groups. Drinking water including 10% fructose solution was given to rats for 12 weeks to develop a MeS rat model. Animals with MeS were submitted to EX and/or CR for 6 weeks. Blood glucose, and brain tissue damage and antioxidant parameters were measured. Brain lipid peroxidation, sialic acid, mucin, fucose levels increased in the MeS group compared to the control (C) group. These parameters reduced significantly in the metabolic syndrome with caloric restriction (MeS+CR) group, and more significantly in the metabolic syndrome with exercise and caloric restriction group (MeS+EXCR), compared to the MeS group. Glutathione levels, superoxide dismutase and catalase activities decreased in the MeS group compared to the C group, increased both in the MeS+CR group, and MeS+EXCR group compared to the MeS group. High fructose diet consumption can lead to brain tissue damage and decreased antioxidant levels were found to be improved best in the MeS+EXCR group.