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YARAT, AYŞEN

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Author: AK, ESİN ×

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    Kronik periodontitisli ve sağlıklı kişilerin tükürük örneklerinin bazı biyokimyasal parametreler ve sitolojik incelemeler açısından karşılaştırılmasında saklama süresinin belirlenmesi
    (2009-06-20) ALTURFAN, EBRU IŞIK; YARAT, AYŞEN; AK, ESİN; ALTURFAN E. I., YARAT A., AK E., PİŞİRİCİLER R., KURU B., NOYAN Ü.
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    PublicationOpen Access
    Tooth replantation with adipose tissue stem cells and fibrin sealant: microscopic analysis of rat's teeth
    (SPRINGER INTERNATIONAL PUBLISHING AG, 2016-12) YARAT, AYŞEN; Demirel, Sezin; Yalvac, Mehmet Emir; Tapsin, Sidika; Akyuz, Serap; Ak, Esin; Cetinel, Sule; Yarat, Aysen; Sahin, Fikrettin
    Treatment for dental avulsion cases is early or late replantation of the traumatized teeth. Prognosis of the replanted tooth depends on the level of periodontal injury. Adipose tissue stem cells (ATSCs) were reported to improve periodontal ligament tissue (PDL) regeneration. Fibrin sealant (FS) contains thrombin and fibrinogen to form an adhesive fibrin clot routinely used in surgical procedures. Here, we aimed to investigate the effects of ATSCs + FS treatment on healing of PDL after tooth replantation in a rat model. After 60 min of extraction, maxillary central incisor teeth were replanted with ATSCs + FS. Two months later, the rats were sacrificed and hemimaxilla blocks were dissected out for histological analysis. The results showed that there was a significant improvement in histological findings of ATSCs + FS treated group compared to only FS treated and non-treated groups corresponding to reduced inflammatory resorption and increased new PDL formation. Furthermore, the ankylosis levels were lowered after ATSCs + FS treatment. Singular use of FS improved PDL healing moderately. Our results indicated that ATSCs + FS treatment improves PDL healing after tooth replantation suggesting a new therapeutic potential in the treatment of dental avulsion cases.
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    PublicationOpen Access
    Investigation of the Effects of Edaravone on Valproic Acid Induced Tissue Damage in Pancreas
    (MARMARA UNIV, FAC PHARMACY, 2017-06-20) YARAT, AYŞEN; Oktay, Sehkar; Alev-Tuzuner, Burcin; Tunali, Sevim; Ak, Esin; Emekli-Alturfan, Ebru; Tunali-Akbay, Tugba; Koc-Ozturk, Leyla; Cetinel, Sule; Yanardag, Refiye; Yarat, Aysen
    Valproic acid (VPA), an effective antiepileptic and anticonvulsant drug, has some toxic side effects due to causing elevated oxidant production. The aim of this study is to investigate the effects of edaravone, a potent free radical scavenger on VPA induced toxicity and tissue damage by biochemical and histological examinations on pancreas. Female Sprague Dawley rats were divided into four groups as follows; control, edaravone, VPA, VPA+edaravon. VPA and edaravone were injected intraperitonally for seven days. Total protein, lipid peroxidation (LPO), sialic acid (SA) and glutathione (GSH) levels and alkaline phosphatase (ALP), tissue factor (TF), superoxide dismutase (SOD), glutathione-S-transferase GST), catalase (CAT), glutathione peroxidase (GPx) and myeloperoxidase (MPO) activities were determined in pancreas homogenates. In VPA given group, LPO and SA levels, and ALP, TF, MPO activities significantly increased and GST, CAT, GPx activities significantly decreased compared to control group. A marked morphological damage was detected in the VPA group. Ameliorative effects of edaravone were observed in SA, TF, CAT, GPx parameters and histological examination in the VPA group. Therefore, edaravone may be effective in moderation and/or reduction of toxic effects of VPA on pancreas.
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    Cytological investigation of saliva samples of disabled children
    (2013-07-11) ALTURFAN, EBRU IŞIK; AK, ESİN; YARAT, AYŞEN; PİŞİRİCİLER R., ALTURFAN E. I., OZBAY G., AK E., AKYÜZ S. H., YARAT A.
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    In vitro effect of aqueous plant extracts on antioxidant parameters in saliva samples
    (2011-11-13) YARAT, AYŞEN; AK, ESİN; YARAT A., SAÇAN Ö., AKYÜZ S. H., PİŞİRİCİLER R., AK E., YANARDAĞ R.
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    Melatonin improves hyperglycemia induced damages in rat brain
    (WILEY, 2018) YARAT, AYŞEN; Gurel-Gokmen, Begum; Ipekci, Hazal; Oktay, Sehkar; Alev, Burcin; Ustundag, Unsal Veli; Ak, Esin; Akakin, Dilek; Sener, Goksel; Emekli-Alturfan, Ebru; Yarat, Aysen; Tunali-Akbay, Tugba
    Background Diabetes mellitus is an endocrine disorder which is characterized by the development of resistance to the cellular activity of insulin or inadequate insulin production. It leads to hyperglycemia, prolonged inflammation, and oxidative stress. Oxidative stress is assumed to play an important role in the development of diabetic complications. Melatonin is the hormone that interacts with insulin in diabetes. Therefore, in this study, the effects of melatonin treatment with or without insulin were examined in diabetic rat brain. Methods Results Rats were divided into five groups as control, diabetes, diabetes + insulin, diabetes + melatonin, and diabetes + melatonin + insulin. Experimental diabetes was induced by streptozotocin (60 mg/kg, i.p.). Twelve weeks after diabetes induction, rats were decapitated. Malondialdehyde, glutathione, sialic acid and nitric oxide levels, superoxide dismutase, catalase, glutathione-S-transferase, myeloperoxidase, and tissue factor activities were determined in brain tissue. Melatonin alone showed its antioxidant effect by increasing brain glutathione level, superoxide dismutase, catalase, and glutathione-S-transferase activities and decreasing malondialdehyde level in experimental diabetes. Although insulin did not have a significant effect on glutathione and glutathione-S-transferase, its effects on lipid peroxidation, superoxide dismutase, and catalase were similar to melatonin; insulin also decreased myolopeoxidase activity and increased tissue factor activity. Combined melatonin and insulin treatment mimicked the effects of insulin. Conclusion Addition of melatonin to the insulin treatment did not change the effects of insulin, but the detailed role of melatonin alone in the treatment of diabetes merits further experimental and clinical investigation.
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    Effect of black cumin seed oil on gastric tissues in experimental conditions
    (2010-11-04) ALTURFAN, EBRU IŞIK; YARAT, AYŞEN; AKBAY, TUĞBA; AK, ESİN; ALTURFAN E. I., YARAT A., AKBAY T., IŞIK F., YENİDOĞAN G., ŞENER G., ŞEHİRLİ A. Ö., PİŞİRİCİLER R., AK E., ALTINTAŞ A.
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    Histologic and cytologic evaluatıon of kidney after deuterium depleted water consumption in experimental diabetes
    (2012-07-17) AK, ESİN; ÇETİNEL, ŞULE; YARAT, AYŞEN; PİŞİRİCİLER R., AK E., ÇETİNEL Ş., Çorak A., YARAT A.
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    PublicationOpen Access
    Determination of Storage Time of Saliva Samples Obtained From Patients With and Without Chronic Periodontitis for the Comparison of Some Biochemical and Cytological Parameters
    (WILEY, 2013-07) YARAT, AYŞEN; Emekli-Alturfan, Ebru; Yarat, Aysen; Caliskan-Ak, Esin; Pisiriciler, Rabia; Kuru, Bahar; Noyan, Ulkue
    Background: Salivary glutathione (GSH), malondialdehyde (MDA), protein, sialic acid (SA) levels, cytological parameters, and tissue factor activities (TFa) were investigated when fresh and after 3, 7, 11, 15, 21, and 30 days (d) of storage at -20 degrees C both in the control and the periodontitis group. Moreover, the control and the periodontits groups were compared and continuity of the significances detected between the two groups were evaluated. Methods: GSH, MDA, SA, protein, and TFa were determined using the methods of Beutler, Yagi, Warren, Lowry, and Quick, respectively. Saliva imprint samples were stained with Giemsa and microscopically examined. Results: When the continuity of the significances of differences between the two groups was investigated, differences continued to be significant for GSH and TFa on days 3, 7, 11, 15, 21, and 30. Cytologically, only the significance detected between leucocyte numbers continued to be significant for 30d. However significance of differences in total protein, MDA, and SA levels on day 0, were interrupted on days 3, 7, and 11, respectively. Conclusion: Saliva samples may be stored for 30d for GSH and TFa analyses in patients with and without periodontitis. However, to compare salivary MDA, SA, and total protein levels in these groups we suggest fresh samples to be studied. (C) 2013 Wiley Periodicals, Inc.
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    Oral cerahi işlemlerinde uygulanan lokal hemostatik ajanların erken dönem yumuşak doku iyileşmesi üzerine etkilerinin incelenmesi
    (2023-01-01) GÖNÜL, ONUR; AK, ESİN; ALTURFAN, EBRU IŞIK; YARAT, AYŞEN; GARİP, HASAN; GÖNÜL O., AK E., ALTURFAN E. I., ARBAK S., YARAT A., PİŞİRİCİLER R., GARİP H., SATILMIŞ T., GÖKER M. K.
    Oral cerrahi girişimleri sonrası kanama komplikasyonlarını kontrol altına almak için ticari olarak mevcut pek çok hemostatik ajan kullanılmaktadır. Bu çalışmada, üç farklı lokal hemostatik ajanın erken dönem doku iyileşmesi üzerindeki etkileri histolojik ve sitolojik olarak değerlendirildi. Çalışmaya yarı gömük üçüncü molar diş çekimi yapılan ve çalışma kriterlerine uygun bulunan 41 gönüllü hasta dahil edildi. İşlem sonrası kullanılan hemostatik ajana göre hastalar; oral cerrahi operasyonu sonrası herhangi bir ajan kullanılmayan grup,grup I (kontrol, n=10); ile sırasıyla jelatin, kollajen ve kitosan esaslı lokal hemostatik ajan kullanılan gruplar, grup II (n=11), grup III (n=10), grup IV (n=10) olarak dört gruba ayrıldı. Cerrahi işlem sırasında ve 8. günde doku örnekleri alındı. Histolojik inceleme için her gruptaki hastalara ait dokulardan alınan 5 μm kalınlığındaki kesitlere Masson’s trichrom boyaması yapılarak ışık mikroskopisi altında incelendi. Kesitler doku harabiyeti vazokonjesyon, lökosit infiltrasyonu ve kollajen lif yapısı kriterleri kullanılanarak değerlendirildi. Sitolojik inceleme için dokulardan alınan sürüntü örnekleri May-Grünward ile boyandı. Çalışmamızda kullanılan lokal hemostatik ajanların klinik etkinlikleri yeterli bulundu, kitozan esaslı lokal hemostatik ajanın diğerlerine göre doku iyileşmesini sitolojik ve histolojik olarak daha olumlu yönde etkilediği saptandı. Klinik yararları göz önüne alındığında birçok cerrahi alanda kullanımı yaygın olan bu ajanların doku iyileşme potansiyeline etkilerinin artırılması için konuyu farklı yönlerden inceleyen çalışmaların gerekli olduğu kanısına varıldı.Anahtar kelimeler: Hemostatik ajanlar, jelatin sünger, kollajen, kitozan