Person: YARAT, AYŞEN
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YARAT
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AYŞEN
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Publication Metadata only Boron concentrations in tap water in many cities of Turkey(TAYLOR & FRANCIS LTD, 2020) YARAT, AYŞEN; Kuru, Ruya; Yilmaz, Sahin; Sacan, Ozlem; Yanardag, Refiye; Yarat, Aysen; Sahin, FikrettinBoron concentrations in 335 tap water samples collected from 75 cities in Turkey have been determined by inductively coupled plasma-mass spectrometry. Boron levels ranged between 0.001 and 5.5 mg/L. The lowest boron levels were in Trabzon, the highest in Kayseri. Boron levels in tap water from cities of the Aegean, Eastern, and Central Anatolian Regions were higher than those from cities of the Marmara, Black Sea, South East, and Mediterranean Regions. The overall mean value was around 0.2 mg/L, lower than the limit levels given by the WHO and the European Union, and also the limit level established by Turkish regulations. In some cities, these limit values were exceeded, generally in the tap water of cities where the drinking water based on groundwater or of those located in the vicinity of hot springs, volcanic areas, or boron production regions. This is the most detailed study evaluating boron levels in the drinking water of Turkey. To conclusion, since the boron intake is being mainly with nutrients and drinking water it may effect public health. To know boron levels in drinking waters is also very important for epidemiologic studies and for establishment of database of boron level in drinking waters in Turkey. [GRAPHICS] .Publication Metadata only Brain Boron Level, DNA Content, and Myeloperoxidase Activity of Metformin-Treated Rats in Diabetes and Prostate Cancer Model(SPRINGERNATURE) YARAT, AYŞEN; Ozel, Armagan Begum; Dagsuyu, Eda; Aydin, Pinar Koroglu; Bugan, Ilknur; Bulan, Omur Karabulut; Yanardag, Refiye; Yarat, AysenIn this study, the effect of metformin on boron levels and oxidative brain damage in rats due to diabetes and prostate cancer was investigated for the first time. Myeloperoxidase (MPO) activity and the amount of DNA were investigated as tissue oxidative and toxic damage parameters. In Copenhagen rats, Dunning prostate cancer was induced using high metastatic MAT-Lylu cells and diabetes was induced by single dose of streptozotocin (STZ) injection. Metformin was administered for 14 days after diabetes and prostate cancer induced. The rats were divided into six groups as follows: control group, diabetic group (D), cancer group (C), diabetic + cancer (DC) group, cancer + metformin (CM) group, diabetic + cancer + metformin (DCM) group. At the end of the experiment, brains were removed. Significant decrease of brain boron levels and significant elevation of MPO activity and DNA levels were observed in D, C, and DC groups as compared to control group. The effect of diabetes induction on the brain boron levels was much more than prostate cancer induction. The administration of metformin with CM and DCM obviously declined MPO activity and increased brain boron levels almost near to control group level. In conclusion, this study shows that the protective effect of metformin against brain damage in STZ-induced diabetic rats with Dunning prostate cancer may also be related to increased boron levels. The boron levels may be a novel indicator of reduced toxic and oxidative stress. Furthermore, the distribution and mechanism of action of boron should be clarified.Publication Metadata only Evaluation of Dietary Boron in terms of Health: A Retrospective Study(MARMARA UNIV, INST HEALTH SCIENCES, 2018) YARAT, AYŞEN; Kuru, Ruya; Mutlu, Esra Kurt; Cempel, Ela; Celik, Sedef Belentepe; Yarat, AysenObjective: The aim of this retrospective study was to calculate the amount of daily boron intake according to the daily nutrition diary and to evaluate the effects of boron on health via the results of some biochemical and hematological parameters. Methods: A total of 50 patients who were admitted to the Maltepe Ersoy Hospital Nutrition and Diet Clinic, had some biochemical and hematological examinations, had a weekly nutrition diary, and had anthropometric records were included in the present study. The relationships between daily boron intake and biochemical, hematological, and anthropometric records of the patients were examined. Results: The average daily boron intake was calculated as 1.45 +/- 0.4 (women: 1.4 +/- 0.4 and men: 1.5 +/- 0.5) mg/day and was mostly found in fruits. There was a significant and negative correlation between body mass index and daily boron intake (r=-0.3555, p=0.05); however, no significant relationship was found between daily boron intake level and other parameters. Conclusion: To our knowledge, this is the first study in the literature that presents the dietary boron level in Turkey and also examines the relationship between dietary boron level and biochemical and hematological parameters retrospectively. The results of our study could provide useful information and contribution to ongoing boron studies.Publication Metadata only Boron Content of Some Foods Consumed in Istanbul, Turkey(HUMANA PRESS INC, 2019) YARAT, AYŞEN; Kuru, Ruya; Yilmaz, Sahin; Tasli, Pakize Neslihan; Yarat, Aysen; Sahin, FikrettinThe boron content was determined in 42 different foods consumed in Istanbul, Turkey. Eleven species of fruit, ten species of vegetable, eight species of food of animal origin, four species of grain, two species of nuts, two species of legume, and five other kinds of foods were included to this study. They were analyzed by two methods: Inductively coupled plasma mass spectrometry (ICP-MS) technique and carminic acid assay, and the results of two methods were also compared. Boron concentration in foods ranged between 0.06-37.2mg/kg. Nuts had the highest boron content while foods of animal origin had the lowest. A strong correlation was found between the results of the carminic acid assay and the ICP-MS technique (p=0.0001, Pearson correlation coefficient: r=0.956). Bland Altman analysis also supported this correlation. ICP-MS is one of the most common, reliable, and powerful method for boron determination. The results of our study show that spectrophotometric carminic acid assay can provide similar results to ICP-MS, and the boron content in food materials can be also determined by spectrophotometric method.Publication Metadata only Boron-rich diet may regulate blood lipid profile and prevent obesity: A non-drug and self-controlled clinical trial(ELSEVIER GMBH, 2019) YARAT, AYŞEN; Kuru, Ruya; Yilmaz, Sahin; Balan, Gulsah; Tuzuner, Burcin Alev; Tasli, Pakize Neslihan; Akyuz, Serap; Ozturk, Feyza Yener; Altuntas, Yuksel; Yarat, Aysen; Sahin, FikrettinBackground: Boron is an element commonly found in nature. The main boron source for organisms is through food and drinking water. In recent years, it is suggested that the boron-rich diet can affect human health positively. However, more detailed studies are needed. Objective: The aim of this study was to examine the effect of increased dietary boron intake on some biochemical parameters in humans. Material and methods: Thirteen healthy women consumed diets containing 10 mg more boron than their routine diet for one month. This boron intake was provided with the increase of boron-rich foods such as dried fruits, avocado, and nuts in the diet. Some biochemical and hematologic parameters were determined in blood, urine and saliva samples taken before and after a boron-rich diet. Results: Serum, salivary, and urine boron concentrations increased 1.3, 1.7, 6.0 fold, respectively. The most significant clinically change was found in the lipid profile. Serum total, LDL, VLDL cholesterol, and triglyceride levels decreased significantly. Body weight, body fat weight, and Body Mass Index also decreased. Significant changes in serum TSH and salivary buffering capacity were also found. Conclusion: Increasing the intake of boron through dietary means might contribute to beneficial effects on lipid metabolism, obesity, and thyroid metabolism; salivary boron may reflect serum boron; and boron may be used as a cariostatic agent in dentistry. An increased intake of other dietary factors such as fiber, potassium, iron, vitamin A, and vitamin E in the boron-rich foods might have been responsible of the effects described. To our knowledge, this study is the first clinical study in which dietary boron intake is increased via foods.Publication Metadata only Boron and a Current Overview of its Effects On Health(AVES PRESS LTD, 2017) YARAT, AYŞEN; Kuru, Ruya; Yarat, AysenBoron is an element that naturally exists as compounds and has the most reserves in our country. Boron compounds are used in glass, ceramics, cleaning, whitening, cosmetic, metallurgy, nuclear, computer, aircraft, energy, agricultural, and health industries. It enters the body through nutrients and drinking water. Recent studies have focused on the biological importance of boron and its positive effects on human health and have emphasized the importance of its role in mineral and hormone metabolisms, bone development, antioxidant defense system, wound healing, energy metabolism, and immune system. Here we review the importance of boron in our nutrition and its effects on health.