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ÖZBEYLİ, DİLEK

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Author: ERTAŞ, BÜŞRA × Subject: Myrtus communis ×

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    Evaluation of the protective effect of Myrtus communis in scopolamine induced Alzheimer model through cholinergic receptors
    (ELSEVIER, 2019) ŞEN, ALİ; Aykac, Asli; Ozbeyli, Dilek; Uncu, Murat; Ertas, Busra; Kilinc, Olca; Sen, Ali; Orun, Oya; Sener, Goksel
    Alzheimer's disease is a progressive neurodegenerative disorder causing common health problem with increasing age. Evidences show that the key symptoms of AD are mainly caused by cholinergic system dysfunction which has a role in cognitive disorders. Cholinergic pathways especially muscarinic receptors like M-1 subtype also have a major role in learning, memory, cognitive functions and emotional state. There is no available permanent treatment currently to cure AD or to change its progression. This study was designed to investigate the factors that play important role in pathogenesis of AD and to compare the effects of Galantamine treatment with effects of Myrtus communis treatment. The expression level of M-1, ACh, BDNF; AChE activity, GSH level, MDA and MPO activity and AChE gene expression were investigated in scopolamine-induced rat model. Results showed that, administration of MC significantly improves the SCOP-induced reduction of latency and object recognition time; increasing BDNF, M-1 and ACh receptor expression levels in the different brain regions. Additionally, MC showed an increased in AChE by enhancing GSH activity and reducing MDA level and MPO activity. In conclusion MC considered as a possible novel therapeutic approach that can be a valuable alternative way in the prevention and treatment of AD.
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    Myrtus communis extract ameliorates high-fat diet induced brain damage and cognitive function
    (MARMARA UNIV, 2020) ŞEN, ALİ; Ozbeyli, Dilek; Yarimbas, Gizem; Ertas, Busra; Sen, Ali; Sakarcan, Selin; Sener, Goksel
    Obesity causes cognitive weakening and increases the risk of neurodegenerative diseases. Myrtus connnunis extract (MC) has anti-inflammatory and antioxidant properties. In this study, it is aimed to investigate the effects of Myrtus comniunis on oxidative brain damage caused by a high-fat diet (HFD), using behavioral and biochemical parameters. Twenty- four Wistar albino rats (200-250 g) were divided into three groups. The control group (C) received a standard diet, while HFD groups were received HFD for 16 weeks. MC (100 mg/kg, oral) was given to the HFD + MC group for the last 4 weeks. At the end of the study, the novel object recognition test (NORT) was performed and the hippocampus and blood samples were collected. Acetylcholinesterase (AChE) and Na+/K+- ATPase activities, malondialdehyde (MDA), 8-hydroxy-2'-deoxyguanosine (8-0HdG) and reduced glutathione (GSH) levels were measured in the hippocampal samples and cholesterol levels were analyzed in sera. Findings have shown that NORT performance of the HFD group was reduced, while administration of MC prevents this reduction and in parallel, increased AChE and decreased Na+/K+-ATPase activities were ameliorated by administration of MC. Increased MDA and 8-OHdG levels observed in the HFD group, were decreased in the MC treated HFD group. Our results point out that MC has ameliorative effects on hippocampal oxidative stress and cognitive impairment in high fat nutrition-induced obesity.