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ÖZBEYLİ, DİLEK

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Author: KAYA, ÖZLEM TUĞÇE × Subject: acute pancreatitis ×

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    Myrtus communis leaf extract protects against cerulein-induced acute pancreatitis in rats
    (WILEY, 2020) ŞEN, ALİ; Ozbeyli, Dilek; Sen, Ali; Kaya, Ozlem Tugce Cilingir; Ertas, Busra; Aydemir, Sezgin; Ozkan, Naziye; Yuksel, Meral; Sener, Goksel
    In this study, the aim was to examine the potential protective effects of Myrtus communis subsp. communis leaf ethanol extract (MC) treatment against acute pancreatitis (AP) in rats. Thirty-two rats were grouped as the saline-pretreated control (C), MC-pretreated control (MC), saline-pretreated AP (AP), and MC-pretreated AP (MC + AP) groups. To induce AP, cerulein was administered (50 mu g/kg) two times. The rats were given MC for 14 days before cerulein injection. Six hours after the final cerulein injection, the rats were sacrificed. Pancreatic damage was associated with an increase in the serum activity of lipase and amylase, the pancreatic activity of myeloperoxidase, and the pancreatic level of malondialdehyde, interleukin-1 beta, and interleukin-6. AP also led to a decrease in the pancreatic level of anti-inflammatory interleukin-10 and glutathione. Pretreatment with MC before the induction of AP significantly reduced the pancreatic damage observed during the histological examination as well as reversed the biochemical changes evoked by AP. Practical applications Acute pancreatitis is characterized by high mortality (average about 5%; severe cases may reach about 30%). The current treatment for acute pancreatitis is mainly symptomatic. The introduction of herbal drugs may lead to the development of a new strategy in the treatment of this disease. This study revealed that MC reduced pancreatic injury by decreasing pro-inflammatory cytokines, increasing antioxidant capacity and anti-inflammatory cytokine, IL-10. To the authors' knowledge, this research is the first report showing that MC inhibits the development of AP. This observation suggests that MC may be useful in the prevention and the treatment of AP in clinical settings.
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    Deep learning-based histological scoring of cerulein-induced acute pancreatitis rat model
    (2022-01-01) KAYA, ÖZLEM TUĞÇE; ÖZBEYLİ, DİLEK; Aykac A., Mirzaei O., KAYA Ö. T. , ÖZBEYLİ D., Suer K.
    © 2022 IEEE.In an experimental rat model of acute cerulein-induced pancreatitis, we aimed to investigate the ability of the deep neural network-based program to distinguish damaged cell structures in histological preparations derived from rat pancreatic tissues. After the pancreatic tissues of all rats underwent the paraffin procedure, 3-4 pm thick sections were taken from the paraffin blocks, stained with hematoxylin-eosin dye, evaluated with a light microscope and photographed using a light microscope. 89 mixed-size microscopic images are resized at 224*224 diameter. The datasets were divided into train, validation and test groups. The algorithm used in this study was based on the NAS-Net-Mobile and ResNet-101 models from MATLAB Transfer Learning. By increasing the number of samples in the method we use in histology, both the evaluation performance and time consumption are reduced with the Al we use. The accuracy rate we obtained with NAS-Net mobile was determined to be higher than ResNet-101.