Person: UZUN, MUHAMMET
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UZUN
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MUHAMMET
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Publication Metadata only A study on hemp seed oil/polycaprolactone based wound dressing structures by making use of additive manufacturing methods(2022-12-07) UZUN, MUHAMMET; ALTAN, ERAY; GÜNDÜZ, OĞUZHAN; Ertaş İ. F., Kabir M. H., UZUN M., ALTAN E., GÜNDÜZ O.Publication Metadata only Tissue engineering applications of bacterial cellulose based nanofibers(Springer, 2020-01-01) ÜNAL YILDIRIM, SEMRA; GÜNDÜZ, OĞUZHAN; UZUN, MUHAMMET; ÜNAL S., GÜNDÜZ O., UZUN M.Publication Metadata only Fabrication, characterization and investigation of antibacterial activity of propolis substituted sodium alginate tissue scaffolds using three-dimensional (3d) printing technology(2021-06-05) UZUN, MUHAMMET; SU TORUN, SENA; ULAĞ, SONGÜL; AKSU, MEHMET BURAK; GÜNDÜZ, OĞUZHAN; CESUR, SÜMEYYE; Aarancı K., Uzun M., Su Torun S., Cesur S., Ulağ S., Amin A., Güncü M. M., Aksu M. B., Kolaylı S., Silva J., et al.Publication Metadata only Study on potential of additive manufactured wound dressing from hemp seed oil/polycaprolactone(2022-11-06) UZUN, MUHAMMET; ALTAN, ERAY; TINAZ, GÜLGÜN; GÜNDÜZ, OĞUZHAN; Ertaş İ. F., UZUN M., ALTAN E., Kabir M. H., TINAZ G., GÜNDÜZ O.Publication Metadata only 3D-Printed lanolin-based sodium alginate wound dressings(Springer, 2021-01-01) UZUN, MUHAMMET; GÜNDÜZ, OĞUZHAN; UZUN M., Kuyumcu A. D., GÜNDÜZ O.Publication Open Access 3D Propolis-Sodium Alginate Scaffolds: Influence on Structural Parameters, Release Mechanisms, Cell Cytotoxicity and Antibacterial Activity(MDPI, 2020-11-02) AKSU, MEHMET BURAK; Aranci, Kubra; Uzun, Muhammet; Su, Sena; Cesur, Sumeyye; Ulag, Songul; Amin, Al; Guncu, Mehmet Mucahit; Aksu, Burak; Kolayli, Sevgi; Ustundag, Cem Bulent; Silva, Jorge Carvalho; Ficai, Denisa; Ficai, Anton; Gunduz, OguzhanIn this study, the main aim was to fabricate propolis (Ps)-containing wound dressing patches using 3D printing technology. Different combinations and structures of propolis (Ps)-incorporated sodium alginate (SA) scaffolds were developed. The morphological studies showed that the porosity of developed scaffolds was optimized when 20% (v/v) of Ps was added to the solution. The pore sizes decreased by increasing Ps concentration up to a certain level due to its adhesive properties. The mechanical, swelling-degradation (weight loss) behaviors, and Ps release kinetics were highlighted for the scaffold stability. An antimicrobial assay was employed to test and screen antimicrobial behavior of Ps against Escherichia coli and Staphylococcus aureus strains. The results show that the Ps-added scaffolds have an excellent antibacterial activity because of Ps compounds. An in vitro cytotoxicity test was also applied on the scaffold by using the extract method on the human dermal fibroblasts (HFFF2) cell line. The 3D-printed SA-Ps scaffolds are very useful structures for wound dressing applications.Publication Metadata only An overview of the use of dental stem cells and polycaprolactone scaffolds in tissue engineering(2021-01-01) ÇALIKOĞLU KOYUNCU, AYŞE CEREN; UZUN, MUHAMMET; GÜNDÜZ, OĞUZHAN; ÇALIKOĞLU KOYUNCU A. C. , Doğan E., UZUN M., GÜNDÜZ O.Dental tissues have been discovered as a pool of stem cells with multiple differentiation potencies in recent decades. Stem cells with different differentiation potential, but particularly of mesenchymal origin, could easily be isolated from dental pulp, periodontal ligament, apical papilla, dental follicle, and gingiva, as well as the exfoliated deciduous teeth and third molar teeth germs. Polycaprolactone is a well-known biomaterial that has been used in the engineering of many tissues for more than 30 years because of its excellent tailorability and availability. This chapter will review the types of dental stem cells, techniques in producing polycaprolactone scaffolds, and different tissue engineering applications involving dental stem cells and polycaprolactone.Publication Metadata only 3D Printing Artificial Blood Vessel Constructs Using PCL/Chitosan/Hydrogel Biocomposites(WILEY-V C H VERLAG GMBH, 2019) YILMAZ, BETÜL; Ulag, Songul; Kalkandelen, Cevriye; Oktar, Faik Nuzhet; Uzun, Muhammet; Sahin, Yesim Muge; Karademir, Betul; Arslan, Sema; Ozbolat, Ibrahim Tarik; Mahirogullari, Mahir; Gunduz, OguzhanThe present paper aims to overcome the problems related to previous use of autologous grafts using available synthetic grafts. To examine the optimum of the ideal vessel-like constructs parameters are produced at 230 degrees C. At this production temperature, the elastic modulus values of the constructs ranges from 56 MPa to 174 MPa. The maximum cell proliferation is obtained from PCL/7wt.%CS/5wt.%H that is tested by mitochondrial dehydrogenase activity. The structures are visualized with all constructs after cell fixation by making use of the HUVEC cell line.Publication Metadata only Polylactic acid/Sodyum Alginate/Orange Oyster Shell based nanofiber composite design(2018-11-08) UZUN, MUHAMMET; EKREN, NAZMİ; OKTAR, FAİK NÜZHET; GÜNDÜZ, OĞUZHAN; CESUR, SÜMEYYE; Uzun M., Cesur S., Ekren N., Oktar F. N., Gündüz O.Publication Metadata only 3D bio-printing of levan/polycaprolactone/gelatin blends for bone tissue engineering: Characterization of the cellular behavior(PERGAMON-ELSEVIER SCIENCE LTD, 2019) İNAN, AHMET TALAT; Duymaz, Busra Tugce; Erdiler, Fatma Betul; Alan, Tugba; Aydogdu, Mehmet Onur; Inan, Ahmet Talat; Ekren, Nazmi; Uzun, Muhammet; Sahin, Yesim Muge; Bulus, Erdi; Oktar, Faik Nuzhet; Selvi, Sinem Selvin; ToksoyOner, Ebru; Kilic, Osman; Bostan, Muge Sennaroglu; Eroglu, Mehmet Sayip; Gunduz, OguzhanPoly(epsilon-caprolactone) (PCL), gelatin (GT) and different concentrations of low molecular weight Halomonas levan (HLh) were combined and examined to develop physical networks serving as tissue scaffolds to promote cell adhesion for biocompatibility. Three-dimensional bioprinting technique (3D bioprinting) was employed during manufacturing the test samples and their comprehensive characterization was performed to investigate the physicochemical properties and biocompatibility. Physical properties of the printing materials such as viscosity, surface tension, and density were measured to determine optimal parameters for 3D bioprinting. The scanning electron microscope (SEM) was used to observe the morphological structure of scaffolds. Fourier-Transform Infrared Spectroscopy (FT-IR) and differential scanning calorimetry (DSC) were used to identify the interactions between the components. In-vitro cell culture assays using standard human osteoblast (Hob) cells showed increased biocompatibility of the printing materials with increasing HLh content. Thus, the formulations including the HLh are expected to be a good candidate for the production of 3D printed materials.