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AKSOY, HALİL

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AKSOY

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HALİL

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20202
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    PublicationOpen Access
    The Effect of Algan Hemostatic Agent (AHA) on Wound Healing
    (MARMARA UNIV, INST HEALTH SCIENCES, 2020-09-04) ŞEN, ALİ; Aksoy, Halil; Sener, Azize; Akakin, Dilek; Sen, Ali; Ozakpinar, Ozlem Bingol; Ozcan, Sinemcan; Simsek, Ahmet Kaan; Sekerler, Turgut; Guzel, Sevket Ergun; Midi, Ahmet
    Objective: The Algan Hemostatic Agent (AHA) is a novel herbal originated blood stopper. The aim of this study is to investigate the effect of AHA on wound healing on excisional wound model in rats. Methods: In this study, 54 adult Wistar albino rats were used. Rats were divided into 3 groups (saline, Madecassol (R) and AHA). Each group was then divided into 3 subgroups as the 3rd, 7th and 14th days. Two wounds were created in the dorsal thoracic region of the rats. One of the lesions was used for histopathological examinations and the other for hydroxyproline measurement. In order to evaluate the wound healing, wound area were measured during the whole treatment period and animals were sacrificed at the end of the 3rd, 7th and 14th days and tissue samples were taken for the determination of hydroxyproline levels. Results: AHA treatment did not cause significant difference in hydroxyproline level on days 3, 7, 14. The contraction percentage of wound area was higher in the AHA group on day 7 than that of the control group. However, the difference was not statistically significant (p>0.05). On days 3 and 14, no significant difference was detected in the contraction percentage of wound area between the control and the AHA groups. AHA and Madecassol (R) results of epidermis regeneration on the 14th day, neutrophil infiltration on the 7th day and edema on the 3rd, 7th and 14th days were different in terms of histopathological parameters compared to the control group. Conclusion: Despite good histological findings, AHA did not significantly accelerate wound healing, but did not adversely affect wound healing as well.
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    PublicationOpen Access
    Evaluation of the Biological and Wound Healing Activities of Centaurea virgata Lam.
    (MARMARA UNIV, INST HEALTH SCIENCES, 2020-09-10) AKSOY, HALİL; Aksoy, Halil
    Objective: Plants have significant potential effects in treating wounds. Some plants are also used in traditional medicine for their wound healing properties. The aim of this study was to investigate the antioxidant and in vitro wound healing activities of Centaurea virgata. Methods: The antioxidant activities ofextracts were examined by 2,2-diphenyl-1-picryl-hydrazyl (DPPH) and 2,2-azinobis-(3-ethylbenzothiazoline-6-sulphonic acid (ABTS) methods. The total phenolic content was determined using the Folin-Ciocalteu reagent (FCR) method. In addition, the antiproliferative activity of different extracts on fibroblast cells was performed by MTT method and in vitro wound healing activity of ethanol extract of C. virgata was determined by scratch assay. Results: Ethyl acetate fraction of ethanol extract of C. virgata (CVEA) had the highest DPPH radical scavenging activity with an IC50 value of 138.7 mu g/mL. According to ABTS results, it was determined that the CVEA had a stronger radical scavenging activity than the other extracts. Hexane (CVH) and aqueous ethanol fractions (CVAE) revealed poor antioxidant activity with IC50 values of 824.8 mu g/mL and 610.3 mu g/mL, respectively. On the other hand, among all of the extracts analysed, it was found that phenolic content of CVEA was higher than other extracts. Except for CVAE, other extracts showed antiproliferative activity depending on the dose. Conclusion: According to the obtained results, our finding suggests that CVAE has a migratory effect on fibroblasts and that CVAE might be a potential therapeutic agent for wound healing.