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AKSOY, HALİL

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AKSOY

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HALİL

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2019 - 20202
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Subject: ANTIOXIDANT ×

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    Effect of Horse-chestnut seed extract on matrix metalloproteinase-1 and-9 during diabetic wound healing
    (WILEY, 2019) ŞEN, ALİ; Aksoy, Halil; Cevik, Ozge; Sen, Ali; Goger, Fatih; Sekerler, Turgut; Sener, Azize
    The effects of aqueous-ethanol extract of Horse chestnut (HCE) on MMP-1 and MMP-9 expressions during cutaneous wound healing in diabetic rats were investigated in this study. The expressions of MMP-1 and MMP-9, wound closure, myeloperoxidase (MPO) activity, hydroxyproline, and malondialdehyde (MDA) levels in wound tissue were measured. Quercetin glucuronide in HCE was identified as main compound using a LC-MS/MS. The hydroxyproline level was significantly increased in the treated group versus control after the 3rd and 7th days (p < 0.05). The MDA level and MPO activity were significantly lower in the treatment group (p < 0.05). MMP-1 gene expression level in treated rats was increased in the 7th day while it was reduced in 14th day. MMP-9 gene expression level in treated rats was decreased in 7th, and 14th days compared to control (p < 0.05). These results show that HCE accelerated the cutaneous wound-healing process in diabetic rats via MMP-1 and MMP-9 regulation.
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    PublicationOpen Access
    Evaluation of the Biological and Wound Healing Activities of Centaurea virgata Lam.
    (MARMARA UNIV, INST HEALTH SCIENCES, 2020-09-10) AKSOY, HALİL; Aksoy, Halil
    Objective: Plants have significant potential effects in treating wounds. Some plants are also used in traditional medicine for their wound healing properties. The aim of this study was to investigate the antioxidant and in vitro wound healing activities of Centaurea virgata. Methods: The antioxidant activities ofextracts were examined by 2,2-diphenyl-1-picryl-hydrazyl (DPPH) and 2,2-azinobis-(3-ethylbenzothiazoline-6-sulphonic acid (ABTS) methods. The total phenolic content was determined using the Folin-Ciocalteu reagent (FCR) method. In addition, the antiproliferative activity of different extracts on fibroblast cells was performed by MTT method and in vitro wound healing activity of ethanol extract of C. virgata was determined by scratch assay. Results: Ethyl acetate fraction of ethanol extract of C. virgata (CVEA) had the highest DPPH radical scavenging activity with an IC50 value of 138.7 mu g/mL. According to ABTS results, it was determined that the CVEA had a stronger radical scavenging activity than the other extracts. Hexane (CVH) and aqueous ethanol fractions (CVAE) revealed poor antioxidant activity with IC50 values of 824.8 mu g/mL and 610.3 mu g/mL, respectively. On the other hand, among all of the extracts analysed, it was found that phenolic content of CVEA was higher than other extracts. Except for CVAE, other extracts showed antiproliferative activity depending on the dose. Conclusion: According to the obtained results, our finding suggests that CVAE has a migratory effect on fibroblasts and that CVAE might be a potential therapeutic agent for wound healing.