Person: ÇELEBİLER, ÖZHAN BEKİR
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ÇELEBİLER
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ÖZHAN BEKİR
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Publication Metadata only Repair of critical size defects using bioactive glass seeded with adipose-derived mesenchymal stem cells(WILEY, 2017) YILMAZ, BETÜL; Sacak, Bulent; Certel, Furkan; Akdeniz, Zeynep D.; Karademir, Betul; Ercan, Feriha; Ozkan, Naziye; Akpinar, Ihsan Nuri; Celebiler, OzhanBioactive glass has been demonstrated as a biocompatible bone substitute. However bone healing process can be prolonged due to late resorption of the material. Adipose derived stem cells (ASC) have osteogenic differentiation potential and hence can be a cell source for bone regeneration. The aim of this study was to test whether combination of bioactive glass with ASCs would enhance bone regeneration. Following creation of critical sized defects on the calvaria of 32 Wistar rats, the animals were randomly divided into four groups: Group C (control): Defects were left untreated; Group G: Defects were covered with autologous bone graft; Group BG: Defects were filled with bioactive glass; Group BG/ASC: Defects were filled with bioactive glass seeded with ASCs. The defect size was significantly greater in Group compared to all other groups. Bone density was significantly lower in Group C compared to Group G and Group BG/ASC. Bone regeneration score of Group C was significantly lower than other groups. Group BG/ASC demonstrated lamellar bone and havers canal formation. The results of this study demonstrated that bioactive glass implanted with ASC is a biocompatible construct stimulating radiologically and histologically evident bone regeneration similar to autologous bone grafting. (C) 2016 Wiley Periodicals, Inc.Publication Metadata only Use of abdominal negative pressure wound therapy in different indications: a case series(MA HEALTHCARE LTD, 2019) EROL, BÜLENT; Kocaaslan, Fatma Nihal Durmus; Ozkan, Melekber Cavus; Akdeniz, Zeynep; Sacak, Bulent; Erol, Bulent; Yuksel, Mustafa; Celebiler, OzhanNegative pressure wound therapy (NPWT) is a widely used wound management system. Several articles have been published on the advantages and complications of this system. Abdominal dressing negative pressure system (abdominal NPWT) is a newer technology, developed and used in open abdomen cases. The adherence of the sponge to the intra-abdominal organs is prevented by a polyurethane foam. This study presents a number of case series where an abdominal NPWT (ABThera, KCl, US) has been used to treat other vital organs, helping to prevent complications such as organ rupture and fatal bleeding.Publication Metadata only Cryosurgery combined with free fibular flap in the treatment of local agressive tumors: Preliminary results(2017-06-17) SAÇAK, BÜLENT; AKDENİZ DOĞAN, ZEYNEP DENİZ; KAYA, ZAFER; ŞENDUR, SAMET; DURMUŞ KOCAASLAN, FATMA NİHAL; ÇELEBİLER, ÖZHAN BEKİR; SAÇAK B., AKDENİZ DOĞAN Z. D., KAYA Z., ŞENDUR S., DURMUŞ KOCAASLAN F. N., ÇELEBİLER Ö. B.Publication Metadata only The effect of 2 different distraction-compression models on new bone generation(2012) ÇELEBİLER, ÖZHAN BEKİR; Özgl S., Akdeniz Z.D., Çelebiler Ö., Alcan T., Sav A.To compare the stimulating effect of distraction and 2 different distraction-compression models on maturation of new bone during healing. Thirty adult Sprague-Dawley rats underwent unilateral mandibular osteotomy. The animals were divided into 3 groups. A unidirectional external distraction device was fixed to the mandible. A total of 4 mm of distraction was planned in all groups. After a latency period of 3 days, 0.2 mm of distraction was performed twice a day for 10 days in the distraction group. In the intermittent distraction-compression group, 0.2 mm of distraction was performed twice a day for 3 days, followed by 0.2 mm of compression twice a day for 1 day. In the overdistraction-compression group, 0.2 mm of distraction was performed twice a day for 14 days, followed by 0.2 mm of compression twice a day for 4 days. After a consolidation period of 6 weeks in all groups, animals were killed for macroscopic, microscopic, and radiologic evaluation. Radiologic evaluation proved that more mature bone generation occurred in the groups in which compression was added to distraction. The number of osteoblasts in the intermittent distraction-compression group was significantly higher than that in the distraction group and overdistraction-compression group (P < .001). The highest number of vessels was found in the intermittent distraction-compression group (17.7 ± 6.4) (P < .001). The intermittent distraction- compression model was found to generate greater new bone compared with distraction alone. In clinical applications, to increase the quality of the bone and to shorten the consolidation period, compression can be applied during distraction. © 2012 American Association of Oral and Maxillofacial Surgeons.Publication Open Access Assessment of Tissue Perfusion Following Conventional Liposuction of Perforator-Based Abdominal Flaps(KOREAN SOC PLASTIC & RECONSTRUCTIVE SURGERY, 2017-03-15) SAÇAK, BÜLENT; Dogan, Zeynep Deniz Akdeniz; Sacak, Bulent; Yalcin, Dogus; Pilanci, Ozgur; Tuncer, Fatma Betul; Celebiler, OzhanBackground The effect of liposuction on the perforators of the lower abdominal wall has been investigated in several studies. There are controversial results in the literature that have primarily demonstrated the number and patency of the perforators. The aim of this study was to determine the effect of liposuction on the perfusion of perforator-based abdominal flaps using a combined laser-Doppler spectrophotometer (O2C, Oxygen to See, LEA Medizintechnik). Methods Nine female patients undergoing classical abdominoplasty were included in the study. Perforators and the perfusion zones of the deep inferior epigastric artery flap were marked on the patient's abdominal wall. Flap perfusion was quantitatively assessed by measuring blood flow, velocity, capillary oxygen saturation, and relative amount of hemoglobin for each zone preoperatively, after tumescent solution infiltration, following elevation of the flap on a single perforator, and after deep and superficial liposuction, respectively. Results The measurements taken after elevation of the flap were not significantly different than measurements taken after the liposuction procedures. Conclusions The liposuction procedure does not significantly alter the perfusion of perforator-based abdominal flaps in the early period. The abdominal tissue discarded in a classic abdominoplasty operation can be raised as a perforator flap and has been demonstrated to be a unique model for clinical research.Publication Metadata only Superficial Musculoaponeurotic System Flap for Reconstruction of the Intraoral Defects(THIEME MEDICAL PUBL INC, 2013) DURMUŞ KOCAASLAN, FATMA NİHAL; Kocaaslan, Nihal Durmus; Akdeniz, Zeynep Deniz; Celebiler, Ozhan; Numanoglu, AyhanIntraoral tumors are the main causes of the intraoral and maxillofacial defects. Skin grafts and several soft tissue flaps can be used to reconstruct the intraoral defects including local, regional, and free flaps. Here we present a case of intraoral adenocystic carcinoma treated with segmental maxillectomy, resection of the parotid gland, and the buccal mucosa leaving a full-thickness intraoral defect. The defect was covered with a superficial musculoaponeurotic system (SMAS) flap elevated using the preauricular incision. Reconstruction with SMAS flap for temporal defects and parotidectomy defects has been described in the literature. To our knowledge, the use of this flap for intraoral defects has not been reported. The proximity of the flap to the defect and ease of harvest in cases including total parotidectomy are few of the reasons we use and recommend this flap in reconstruction of intraoral defects.