Person: ŞAHİN, ÖZLEM
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ŞAHİN
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ÖZLEM
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Publication Metadata only Isolated bilateral optic neuropathy in acute disseminated encephalomyelitis(SLACK INC, 2003) TOKER, AYŞE EBRU; Toker, E; Yenice, O; Yilmaz, YPublication Metadata only Influence of serum levels of sex hormones on intraocular pressure in menopausal women(LIPPINCOTT WILLIAMS & WILKINS, 2003) TOKER, AYŞE EBRU; Toker, E; Yenice, O; Temel, APurpose: The purpose of this study was to assess the effect that changes in sex hormone levels have on intraocular pressure (IOP) in menopausal women. Subjects and Methods: Thirty menopausal women on hormone replacement therapy and 32 menopausal women who had never received hormone replacement therapy (HRT), matched for age and duration of amenorrhea, participated in this study. Intraocular pressures were measured with Goldmann applanation tonometer. Serum levels were measured for estradiol, free testosterone, and follicle stimulating hormone (FSH). The influence of serum hormone levels on IOP was assessed by correlation analysis. Results: The mean IOP of postmenopausal women receiving HRT (13.29 +/- 2.28 mm Hg) was not significantly different from that of menopausal women not receiving HRT (13.56 +/- 2.5 min Hg, P = 0.24). Higher testosterone levels were associated with higher IOPs in women receiving HRT (r = 0.48, P = 0.02) and in those not receiving HRT (r = 0.42, P = 0.003). No significant correlations were observed between IOP and serum levels of estradiol and FSH in either group. Conclusion: Our data provide evidence for a relation between serum testosterone levels and IOP in menopause. Higher testosterone seems to have a tendency to increase IOP in menopausal women.Publication Open Access The influence of sex hormones on ocular blood flow in women(WILEY, 2003-12) TOKER, AYŞE EBRU; Toker, E; Yenice, O; Akpinar, I; Aribal, E; Kazokoglu, HPurpose: To investigate the influence of sex hormones on ocular haemodynamics, blood flow velocities in the ophthalmic and central retinal arteries and serum levels of sex hormones were measured in pre- and postmenopausal women. Methods: Colour Doppler imaging (CDI) was used to determine the flow velocities (peak systolic velocity [PSV] and end-diastolic velocity [EDV]) and the resistive index (RI) in the ophthalmic and central retinal arteries in 22 premenopausal and 32 postmenopausal women, who had never received hormone replacement therapy. Serum levels were measured for oestradiol, free testosterone and follicle-stimulating hormone. The CDI parameters were compared between the two groups and the influence of serum levels of oestradiol and testosterone on blood flow velocities and the resistive indices were analysed. Results: After correcting for age and mean arterial blood pressure, an analysis of covariance disclosed a significantly lower EDV (p = 0.02) and a significantly higher RI (p = 0.01) in the central retinal artery of postmenopausal women compared with premenopausal women. Partial correlation analysis, controlling for age, revealed significant correlations between the CDI parameters and serum levels of oestradiol and testosterone. For premenopausal women, PSV (r = 0.58, p = 0.04) and EDV (r = 0.73, p = 0.006) in the ophthalmic artery correlated positively with serum oestradiol levels. The RI in the central retinal artery decreased with increasing oestradiol levels in both groups (premenopausal r = - 0.40, p = 0.04; postmenopausal r = - 0.32, p = 0.05). Peak systolic velocity in the central retinal artery correlated negatively (r = - 0.49, p = 0.04), whereas the RI correlated positively (r = 0.53, p = 0.02) with testosterone levels in the premenopausal group. Postmenopausal women with higher testosterone levels had lower EDV (r = - 0.53, p = 0.007) in the central retinal artery and higher RI in both vessels (ophthalmic artery r = 0.48, p = 0.01; central retinal artery r = 0.61, p = 0.002). Conclusion: Our data provide evidence of a relationship between serum sex hormone levels and blood flow velocities and resistive indices in retrobulbar arteries. Oestradiol appears to have beneficial effects on ocular haemodynamics, whereas testosterone may act as an antagonistic to the effects of oestrogen.Publication Metadata only Visual field analysis in patients with Parkinson's disease(ELSEVIER SCI LTD, 2008) MİDİ, İPEK; Yenice, Ozlem; Onal, Sumru; Midi, Ipek; Ozcan, Eda; Temel, Ahmet; I-Gunal, DilekBackground: To evaluate visual field changes in patients with Parkinson's disease. Methods: Standard automated perimetry of 14 patients (28 eyes) with Parkinson's disease (PD) were compared with controls. PD patients with Unified Parkinson's Disease Rating Scale (UPDRS) score below 25 were included in the study. Results: Visual field indices including mean deviation (-4.69 +/- 2.72 vs. -1.71 +/- 1.30, p = 0.0008), pattern standard deviation (3.94 +/- 1.94 vs. 2.30 +/- 0.41, p = 0.001), and corrected pattern standard deviation (3.23 +/- 2.18 vs. 1.20 +/- 0.91, p = 0.003), were significantly worse in patients with PD when compared with the control group. Bilateral glaucoma-like visual field defects were evident in six patients. Conclusion: Parkinson's patients had worse visual field indices suggesting a common insult in the etiopathogenesis of nerve fiber layer damages observed in glaucoma and PD. (c) 2007 Elsevier Ltd. All rights reserved.Publication Metadata only Colobomatous macrophthalmia with microcornea syndrome: report of a new pedigree(2003) TOKER, AYŞE EBRU; Toker, Ebru; Elcioglu, Nursel; Ozcan, Eda; Yenice, Ozlem; Ogut, MehdiColobomatous macrophthalmia with microcornea syndrome (MIM 602499) is a very rare eye malformation. To date, only two families with a total number of eight patients have been reported. We report on 13 additional cases in a single three-generation family and describe the eye findings and quantitative parameters of corneal curvature and axial ocular dimensions. All affected relatives had bilateral involvement with typical inferonasal iris coloboma, chorioretinal coloboma, microcornea, and varying degrees of axial enlargement associated with myopia. Additional findings included flatter corneal curvatures and shallower anterior chambers. Iridocorneal angle abnormalities associated with elevation of intraocular pressure were detected in three patients. The pedigree confirms the autosomal dominant pattern of inheritance with complete penetrance.Publication Open Access Assessment of spatial-contrast function and short-wavelength sensitivity deficits in patients with migraine(NATURE PUBLISHING GROUP, 2007-02) ŞAHİN, ÖZLEM; Yenice, O.; Onal, S.; Incili, B.; Temel, A.; Afsar, N.; Tanridag, T.Aims: To study spatial-contrast function and short-wavelength sensitivity deficits in a migraine population with a disease duration of 30 years or less. Materials and methods: In this prospective, cross-sectional study, we evaluated 28 subjects with migraine headache and 15 nonheadache healthy controls. Visual fields were evaluated using the Humphrey Field Analyzer 750i and the 30-2, blue and yellow threshold programme. Contrast sensitivity (CS) was measured at 1.5, 3, 6, 12, and 18 cpd spatial frequencies, using the Functional Acuity Contrast Test (F.A.C.T.(TM)). The results of the visual field parameters (mean defect (MD) and pattern standard defect (PSD)) and CS were compared with 15 age-equivalent normal subjects. Results: Short-wavelength amplitude perimetry (SWAP) parameters and CS scores at all spatial frequencies were significantly altered in the migraine patients when compared with the control subjects. Visual field parameters correlated significantly with contrast sensitivity scores: positively for MD (r = 0.39, P = 0.01; r = 0.43, P = 0.005; r = 0.56, P = 0.0001; r = 0.45, P = 0.003; r = 0.48, P = 0.0001) and negatively for PSD (r = -0.45, P = 0.003; r = -0.45, P = 0.003; r = -0.51, P = 0.001; r = -0.53, P = 0.0001; and r = -0.67, P = 0.0001) at all (1.5, 3, 6,12, and 18 cpd) spatial frequencies, respectively. Migraine duration correlated negatively with MD (r = -0.42, P = 0.04) and positively with PSD (r = 0.42, P = 0.03). Conclusion: Migraineurs had significantly altered visual field and contrast function at all spatial frequencies to the normal population. These defects share some features with early stages of glaucoma and may relate a possibility for a common vascular disease pathogenesis in these two conditions.Publication Metadata only Reply to Perimetry and migraine deficits may not implicate glaucoma by D.E. Harle and B.J.W. Evans(SPRINGER, 2006) ŞAHİN, ÖZLEM; Yenice, Ozlem; Temel, Ahmet; Incili, Burcin; Tuncer, NesePublication Metadata only Conservative treatment of isolated medial orbital wall fractures(SLACK INC, 2006) ŞAHİN, ÖZLEM; Yenice, Ozlem; Ogut, Mehdi Suha; Onal, Sumru; Ozcan, EdaThe decision to use surgical or nonsurgical treatment for orbital blow-out fractures is still controversial. Previously, it was advocated that all blow-out fractures should be treated surgically based on the conception that extraocular muscles were blown out and trapped in the fracture area. However, a shift to a more conservative approach occurred gradually, most likely due to the evidence of spontaneous improvement. The medical records of two patients who were diagnosed as having an isolated medial wall fracture with medial rectus muscle displacement into the ethmoid sinus, as demonstrated by computed tomography, were reviewed. Both patients showed improvement only with conservative therapy.Publication Open Access The effect of artificial tear administration on visual field testing in patients with glaucoma and dry eye(NATURE PUBLISHING GROUP, 2007-02) ŞAHİN, ÖZLEM; Yenice, O.; Temel, A.; Orum, O.Aim: To examine the effects of artificial tear administration on perimetry of primary open-angle glaucoma patients with dry eye. Methods: A total of 40 patients with primary open-angle glaucoma experienced in automated perimetry with symptoms of dry eye were enrolled in this study. After their pretest visit, they were instructed to use artificial tear four times a day in both eyes for 1 week. After 1 week, patients had visual field testing. Test taking time, reliability parameters (false-positive and false-negative errors) visual field indices and number of depressed points at different probability levels (P < 5%, P < 2%, P < 1%, P < 0.5%) in both total and pattern deviation plots were compared using paired T test. Results: We found significant improvement in reliability parameters (false-positive errors from 2.4 +/- 2.1 to 2.1 +/- 1.9, P = 0.02; and false-negative errors from 7.3 +/- 6.4 to 4.8 +/- 3.6, P = 0.01) and visual field indices (MD increased from 5.97 +/- 5.61 to 4.57 +/- 4.53, P = 0.001; PSD from 4.67 +/- 2.95 to 4.13 +/- 2.77, P = 0.04 and SF decreased from 2.24 +/- 1.23 to 1.83 +/- 0.77, P = 0.04) in the second testing after artificial tear administration. Test time significantly increased from 11.66 +/- 2.55 min to 14.26 +/- 1.36, P = 0.001. The number of depressed points at probability levels P < 1% (P = 0.03) and P < 0.5% (P = 0.04) at total deviation plot and Po2% (P = 0.02) and P < 0.5% (P = 0.009) in pattern deviation plot decreased significantly. Conclusion: Artificial tear administration in glaucomatous patients with dry eye seems to improve significantly reliability parameters and visual field indices.Publication Metadata only FACT contrast sensitivity as a diagnostic tool in glaucoma(2008) ŞAHİN, ÖZLEM; Onal S., Yenice O., Cakir S., Temel A.Purpose: To investigate spatial-contrast sensitivity (CS) assessment as a tool for diagnosis of early glaucoma in patients with good visual acuity. Methods: In this prospective cross-sectional study we evaluate done eye of 50 patients with primary open angle or normotensive glaucoma who were newly diagnosed. All met the 0.6, or better, vision requirement. CS was measured at 1.5, 3, 6, 12, and 18 cycles per degree (cpd) spatial frequencies for one luminance level (85 cd/m2) using the functional acuity contrast test (FACT). Visual fields were evaluated using the Humphrey 750i field analyzer and the 30-2 standard full threshold program. The results from the visual acuity and CS assessments were compared with results for 20 age-matched control subjects. Results: CS scores were significantly lower at all spatial frequencies for the glaucoma patients than for the control subjects. The sensitivity of CS measurements was generally around 50%. Specificity ranged between 68 and 100%. FACT CS scores of less than 22 at 12 cpd spatial frequency provided sensitivity and specificity values concomitantly exceeding 60%. Conclusions: Both the presence of a significant difference between the CS of glaucoma patients and control subjects and a high specificity of contrast sensitivity suggests that the FACT test may be used as a tool for diagnosis of patients with glaucoma, besides other methods such as short-wavelength automated perimetry (SWAP). © Springer Science+Business Media B.V. 2007.