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ÜNAL YILDIRIM, SEMRA

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ÜNAL YILDIRIM

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SEMRA

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2020 - 20223
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Subject: Bacterial cellulose ×

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Now showing 1 - 3 of 3
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    PublicationOpen Access
    3D printing of PVA/hexagonal boron nitride/bacterial cellulose composite scaffolds for bone tissue engineering
    (ELSEVIER SCI LTD, 2020-11) ŞENGÖR, MUSTAFA; Aki, Deniz; Ulag, Songul; Unal, Semra; Sengor, Mustafa; Ekren, Nazmi; Lin, Chi-Chang; Yilmazer, Hakan; Ustundag, Cem Bulent; Kalaskar, Deepak M.; Gunduz, Oguzhan
    In this study, a novel Polyvinyl Alcohol (PVA)/Hexagonal Boron Nitride (hBN)/Bacterial Cellulose (BC) composite, bone tissue scaffolds were fabricated using 3D printing technology. The printed scaffolds were characterized by fourier transform infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), tensile testing, swelling behaviour, differential scanning calorimetry (DSC), and in vitro cell culture assay. Results demonstrated that bacterial cellulose addition affected the characteristic properties of the blends. Morphological studies revealed the homogenous dispersion of the bacterial cellulose within the 12 wt%PVA/0.25 wt%hBN matrix. Tensile strength of the scaffolds was decreased with the incorporation of BC and 12 wt%PVA/0.25 wt%hBN/0.5 wt%BC had the highest elongation at break value (93%). A significant increase in human osteoblast cell viability on 3D scaffolds was observed for 12 wt%PVA/0.25 wt%hBN/0.5 wt%BC. Cell morphology on composite scaffolds showed that bacterial cellulose doped scaffolds appeared to adhere to the cells. The present work deduced that bacterial cellulose doped 3D printed scaffolds with well-defined porous structures have considerable potential as a suitable tissue scaffold for bone tissue engineering (BTE). (c) 2020 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY license (http:// creativecommons.org/licenses/by/4.0/).
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    PublicationOpen Access
    Evaluation of bacterial cellulose/quince seed mucilage composite scaffold for wound dressing
    (2022-04-01) ÜNAL YILDIRIM, SEMRA; GÜNDÜZ, OĞUZHAN; Oran D., Unal S., GÜNDÜZ O.
    Bacterial cellulose (BC) and quince seed mucilage are very promising biological materials. In this study, we reported the design and fabrication of a novel biocompatible scaffold with excellent fibroblast cell proliferation, making it a promising composite scaffold for wound dressings. The composite scaffold was fabricated by ex situ modification of bacterial cellulose by quince seed mucilage. The products were investigated to determine their morphological features, chemical features, and thermal and swelling behaviors. Cell culture and proliferation tests were performed to obtain information on biocompatibility of the scaffolds. This work indicates the novel scaffold provides great potential in wound dressing for clinical application.
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    Production and characterization of bacterial cellulose scaffold and its modification with hyaluronic acid and gelatin for glioblastoma cell culture
    (SPRINGER, 2021) YILMAZ, BETÜL; Unal, Semra; Arslan, Sema; Yilmaz, Betul Karademir; Oktar, Faik Nuzhet; Sengil, Ahmet Zeki; Gunduz, Oguzhan
    Three-dimensional (3D) in vitro cell culture models have recently gained increasing interest in predicting the response of anticancer drugs. In this study first, we tried to obtain a novel hyaluronic acid (HA)/gelatin (Gel) modified bacterial cellulose (BC) composite scaffolds by in situ fermentation method. Morphological and chemical structures, wettability, and thermal stability of scaffolds were evaluated. In particular, the human glioblastoma (GBM) cancer cell line (U251) was seeded into BC/HA/Gel scaffolds to evaluate their potential as in vitro 3D cancer cell culture. MTT proliferation assay, scanning electron microscopy, and confocal microscopy were utilised to determine cell proliferation, morphology and adhesion. The results suggest that our hyaluronic acid and gelatin modified bacterial cellulose scaffold is promising to be used as in vitro 3D culture of GBM cells and may be used to predict treatment response or reactions of new therapeutics.