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ÖZDEMİR KUMRAL, ZARİFE NİGAR

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ÖZDEMİR KUMRAL

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ZARİFE NİGAR

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2013 - 20162
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Author: ŞENER, GÖKSEL × Subject: STRESS ×

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    Estrogen receptor agonists alleviate cardiac and renal oxidative injury in rats with renovascular hypertension
    (TAYLOR & FRANCIS INC, 2016) YEGEN, BERRAK; Kumral, Zarife Nigar Ozdemir; Kolgazi, Meltem; Ustunova, Savas; Cakir, Ozguer Kasimay; Cevik, Ozge Dagdeviren; Sener, Goksel; Yegen, Berrak C.
    Although endogenous estrogen is known to offer cardiac and vascular protection, the involvement of estrogen receptors in mediating the protective effect of estrogen on hypertension-induced cardiovascular and renal injury is not fully explained. We aimed to investigate the effects of estrogen receptor (ER) agonists on oxidative injury, cardiovascular and renal functions of rats with renovascular hypertension (RVH). Female Sprague-Dawley rats were randomly divided as control and RVH groups, and RVH groups had either ovariectomy (OVX) or sham-OVX. Sham-OVX-RVH and OVX-RVH groups received either ER agonist diarylpropiolnitrile (1 mg/kg/day) or ER agonist propyl pyrazole triol (1 mg/kg/day) for 6 weeks starting at the third week following the surgery. At the end of the 9(th) week, systolic blood pressures were recorded, cardiac functions were determined, and the contraction/relaxation responses of aortic rings were obtained. Serum creatinine levels, tissue malondialdehyde, glutathione, superoxide dismutase, catalase levels, and myeloperoxidase activity in heart and kidney samples were analyzed, and Na+, K+-ATPase activity was measured in kidney samples. In both sham-OVX and OVX rats, both agonists reduced blood pressure and reversed the impaired contractile performance of the heart, while ER agonist improved renal functions in both the OVX and non-OVX rats. Both agonists reduced neutrophil infiltration, lipid peroxidation, and elevated antioxidant levels in the heart, but a more ER-mediated protective effect was observed in the kidney. Our data suggest that activation of ER might play a role in preserving the function of the stenotic kidney and delaying the progression of renal injury, while both receptors mediate similar cardioprotective effects.
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    Protective effects of melatonin against spinal cord injury induced oxidative damage in rat kidney: A morphological and biochemical study
    (ELSEVIER GMBH, 2013) YEGEN, BERRAK; Akakin, Dilek; Kiran, Demir; Ozkan, Naziye; Ersahin, Mehmet; Ozdemir-Kumral, Zarife Nigar; Yegen, Berrak; Sener, Goksel
    Spinal cord injury (SCI) induced oxidative stress affects multiple organ systems including the kidney. We studied the possible protective effects of melatonin on SCI-induced oxidative damage in renal tissues of rats. Wistar albino rats (n =24) were exposed to SCI and divided into vehicle- or melatonin-treated SCI groups. Melatonin was administred intraperitoneally at a dose of 10 mg/kg for seven days. Renal tissues were investigated by light and electron microscopy. Furthermore, tissue malondialdehyde (MDA) and glutathione (GSH) levels and myeloperoxidase (MPO) and superoxide dismutase (SOD) activities were also determined. In the vehicle-treated SCI group, the renal histology was disturbed compared to controls, whereas the melatonin-treated SCI group showed significantly reduced degeneration of renal tissue as seen by both light and electron microscopy. MDA levels, MPO and SOD activities were increased and GSH levels were decreased in the vehicle-treated SCI group compared to controls. On the other hand, decreased MDA levels and MPO activities and increased GSH levels were observed in the melatonin-treated SCI group compared to vehicle-treated SCI group. These results showed that experimentally induced SCI caused oxidative stress in the rat kidney, whereas melatonin treatment reduced oxidative stress, suggesting that it may be used as a complementary therapy of renal problems occurring following SCI. (C) 2013 Elsevier GmbH. All rights reserved.