Person: OKTAR, FAİK NÜZHET
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OKTAR
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FAİK NÜZHET
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Publication Metadata only 3D printed bioactive composite scaffolds for bone tissue engineering(Elsevier B.V., 2020) OKTAR, FAİK NÜZHET; Moukbil Y., Isindag B., Gayir V., Ozbek B., Haskoylu M.E., Oner E.T., Oktar F.N., Ikram F., Sengor M., Gunduz O.Bone health and regeneration is crucial to human survival. With the advancement in the bone research area, bone implants have been under scrutiny to find a better material that could help in bone regeneration and growth. A wide range of material has been studied and examined to find the ideal combination. In this paper, a new blend of Tri-calcium phosphate (TCP), polycaprolactone (PCL) and bovine hydroxyapatite (BHA) was introduced to create scaffolds with fused deposition 3d printing. Effect of BHA concentration as a naturally derived and newcomer 3d printing material was investigated via FTIR, XRD, and SEM analyses. In vitro studies were exhibited that 15% (wt/wt) BHA fabricated composite scaffolds possessed more bioactivity than other cases with increasing proliferation and growth rates. © 2019 Elsevier B.V.Publication Metadata only 3D Printing of Gelatine/Alginate/beta-Tricalcium Phosphate Composite Constructs for Bone Tissue Engineering(WILEY-V C H VERLAG GMBH, 2019) OKTAR, FAİK NÜZHET; Kalkandelen, Cevriye; Ulag, Songul; Ozbek, Burak; Eroglu, Gunes O.; Ozerkan, Dilsad; Kuruca, Serap E.; Oktar, Faik N.; Sengor, Mustafa; Gunduz, OguzhanBone tissue engineering studies have brought three-dimensional scaffolds into focus that can provide tissue regeneration with designed porosity and strengthened structure. Current research has concentrated on the fabrication of natural and synthetic polymer-based complex structures that closely mimic biological tissues due to their superior biocompatibility and biodegradabilities. Gelatine/Sodium Alginate hydrogels reinforced with different concentrations of beta-Tricalcium Phosphate (TCP) (10, 13, and 15 wt.%) were studied to form 3D bone tissue. Physical, mechanical, chemical, morphological properties and biodegradability of the constructs were investigated. Furthermore, in vitro biological assay with human osteosarcoma cell line (SAOS-2) was performed to determine the biocompatibility of the constructs. It is found that cell viability rates for all constructs were increased and maximum cell viability rate was attained for 20%Gelatine/2%Alginate/10%TCP (wt.). The present work demonstrates that 3D printed Gelatine/Alginate/TCP constructs with porous structures are potential candidates for bone tissue engineering applications.Publication Open Access 3D Printed Polycaprolactone/Gelatin/Bacterial Cellulose/Hydroxyapatite Composite Scaffold for Bone Tissue Engineering(MDPI, 2020-08-29) ŞAHİN, ALİ; Cakmak, Abdullah M.; Unal, Semra; Sahin, Ali; Oktar, Faik N.; Sengor, Mustafa; Ekren, Nazmi; Gunduz, Oguzhan; Kalaskar, Deepak M.Three-dimensional (3D) printing application is a promising method for bone tissue engineering. For enhanced bone tissue regeneration, it is essential to have printable composite materials with appealing properties such as construct porous, mechanical strength, thermal properties, controlled degradation rates, and the presence of bioactive materials. In this study, polycaprolactone (PCL), gelatin (GEL), bacterial cellulose (BC), and different hydroxyapatite (HA) concentrations were used to fabricate a novel PCL/GEL/BC/HA composite scaffold using 3D printing method for bone tissue engineering applications. Pore structure, mechanical, thermal, and chemical analyses were evaluated. 3D scaffolds with an ideal pore size (similar to 300 mu m) for use in bone tissue engineering were generated. The addition of both bacterial cellulose (BC) and hydroxyapatite (HA) into PCL/GEL scaffold increased cell proliferation and attachment. PCL/GEL/BC/HA composite scaffolds provide a potential for bone tissue engineering applications.