Person: OKTAR, FAİK NÜZHET
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OKTAR
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FAİK NÜZHET
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Publication Metadata only Preparation and characterization of electrospun polylactic acid/sodium alginate/orange oyster shell composite nanofiber for biomedical application(SPRINGER, 2020) BİLĞİÇ ALKAYA, DİLEK; Cesur, Sumeyye; Oktar, Faik Nuzhet; Ekren, Nazmi; Kilic, Osman; Alkaya, Dilek Bilgic; Seyhan, Serap Ayaz; Ege, Zeynep Ruya; Lin, Chi-Chang; Erdem, Serap; Erdemir, Gokce; Gunduz, OguzhanBone tissue engineering has begun to draw attention in recent years. The interactive combination of biomaterials and cells is part of bone tissue engineering. Sodium alginate (SA) is a biologically compatible, degradable, non-toxic natural polymer accepted by the human body and is widely used in the field of tissue engineering. Polylactic acid (PLA) is another type of biodegradable thermoplastic polyester derived from renewable sources which are used in bone tissue engineering and biomedical owing to its biocompatibility and biodegradability. Hydroxyapatite (HA) and tricalcium phosphate (TCP) derived from natural sources such as marine species and bovine bone are biocompatible and non-toxic biomaterials which are used to reconstruct many parts of the skeleton. In this study, PLA, SA with different compositions, and nanofibers obtained by adding orange spiny oyster shell powders (Spondylus barbatus) to them by using electrospining technique. Cell culture study, scanning electron microscopy (SEM), Fourier transform infrared (FTIR) spectroscopy, X-ray diffraction (XRD), and physical analysis such as density, electrical conductivity, surface tension, viscosity measurement, and tensile strength measurement tests were carried out after the production process. Produced nanofibers showed smooth and beadless surface. The average diameters and distributions decreased with the addition of optimum PLA and TCP amount. The tensile strength of nanofibers was enhanced with the additional SA and TCP. The produced nanofibers are compatible with human bone tissue, which are not cytotoxic, and in addition, a high cell efficiency of SaOS-2 cells on the nanofibers was observed with SEM images.Publication Metadata only Fabrication and characterization of pla/sa/ha composite nanofiber by electrospinning for bone tissue engineering applications(2018-07-18) CESUR, SÜMEYYE; EKREN, NAZMİ; KILIÇ, OSMAN; OKTAR, FAİK NÜZHET; BİLĞİÇ ALKAYA, DİLEK; AYAZ SEYHAN, SERAP; GÜNDÜZ, OĞUZHAN; Cesur S., Ekren N., Kılıç O., Oktar F. N., Bilğiç Alkaya D., Ayaz Seyhan S., Ege Z. R., Gündüz O.Publication Metadata only Synthesis and characterization of antibacterial drug loaded beta-tricalcium phosphate powders for bone engineering applications(SPRINGER, 2020) OKTAR, FAİK NÜZHET; Topsakal, Aysenur; Ekren, Nazmi; Kilic, Osman; Oktar, Faik N.; Mahirogullari, Mahir; Ozkan, Ozan; Sasmazel, Hilal Turkoglu; Turk, Mustafa; Bogdan, Iuliana M.; Stan, George E.; Gunduz, OguzhanPowders of beta-tricalcium phosphate [beta-TCP, beta-Ca-3(PO4)(2)] and composite powders of beta-TCP and polyvinyl alcohol (PVA) were synthesized by using wet precipitation methods. First, the conditions for the preparation of single phase beta-TCP have been delineated. In the co-precipitation procedure, calcium nitrate and diammonium hydrogen phosphate were used as calcium and phosphorous precursors, respectively. The pH of the system was varied in the range 7-11 by adding designed amounts of ammonia solution. The filtered cakes were desiccated at 80 degrees C and subsequently calcined at different temperatures in the range between 700-1100 degrees C. Later on, rifampicin form II was used to produce drug-loaded beta-TCP and PVA/beta-TCP powders. All the synthesized materials have been characterized from morphological (by scanning electron microscopy) and structural-chemical (by X-ray diffraction and Fourier transform infrared spectroscopy) point of view. The drug loading capacity of the selected pure beta-TCP powder has been assessed. The biological performance (cytocompatibility in fibroblast cell culture and antibacterial efficacy against Escherichia coli and Staphylococcus aureus) has been tested with promising results. Application perspectives of the designed drug-bioceramic-polymer blends are advanced and discussed. [GRAPHICS] .Publication Metadata only Development of Satureja cuneifolia-loaded sodium alginate/polyethylene glycol scaffolds produced by 3D-printing technology as a diabetic wound dressing material(ELSEVIER, 2020) OKTAR, FAİK NÜZHET; Ilhan, Elif; Cesur, Sumeyye; Guler, Ece; Topal, Fadime; Albayrak, Deniz; Guncu, Mehmet Mucahit; Cam, Muhammet Emin; Taskin, Turgut; Sasmazel, Hilal Turkoglu; Aksu, Burak; Oktar, Faik Nuzhet; Gunduz, OguzhanAcute wounds are a common health problem, with millions of people affected and decreased granulation tissue formation and vascularization, it is also a big challenge for wound care researchers to promote acute wound healing around the globe. This study aims to produce and characterize Satureja cuneifolia plant extract (SC) blended with sodium alginate (SA) /polyethylene glycol (PEG) scaffolds for the potential treatment of diabetic ulcer. SA/PEG scaffolds were prepared by adding different concentrations (1, 3, and 5 wt%) of PEG to 9 wt% SA. The morphological and chemical composition of the resulting 3D printed composite scaffolds was determined using scanning electron microscopy (SEM) and Fourier transforms infrared spectroscopy (FTIR), respectively. Mechanical and thermal properties, swelling, and degradation behaviours were also investigated. The release kinetics of SC were performed. The antimicrobial analysis was evaluated against Escherichia coli and Staphylococcus aureus strains. 3D printed scaffolds have shown an excellent antibacterial effect, especially against gram-positive bacteria due to the antibacterial SC extract they contain. Furthermore, the cell viability of fibroblast (L929) cells on/within scaffolds were determined by the colourimetric MTT assay. The SA/PEG/SC scaffolds show a great promising potential candidate for diabetic wound healing and against bacterial infections. (c) 2020 Elsevier B.V. All rights reserved.Publication Metadata only Part 2: biocompatibility evaluation of hydroxyapatite-based clinoptilolite and Al2O3 composites(SPRINGER, 2017) OKTAR, FAİK NÜZHET; Kalkandelen, C.; Suleymanoglu, M.; Kuruca, S. E.; Akan, A.; Oktar, F. N.; Gunduz, O.The biocompatibility of clinoptilolite/alumina/bovine hydroxyapatite (Cp - Al2O3 - BHA) composite, at different ratio obtained by powder pressing process, were investigated studying the behavior of osteosarcoma (SAOS-2) cells. The biocompatibility was examined by means of cytotoxicity and cytocompatibility tests. The structure and morphology of bioceramic composites were studied by scanning electron microscopy (SEM) and Fourier transform infrared spectroscopy (FTIR) technique. The results showed that these materials have no toxic effects. The natural composite that fabricated in this study may be a promising approach for bone engineering applications.Publication Metadata only 3D printed bioactive composite scaffolds for bone tissue engineering(Elsevier B.V., 2020) OKTAR, FAİK NÜZHET; Moukbil Y., Isindag B., Gayir V., Ozbek B., Haskoylu M.E., Oner E.T., Oktar F.N., Ikram F., Sengor M., Gunduz O.Bone health and regeneration is crucial to human survival. With the advancement in the bone research area, bone implants have been under scrutiny to find a better material that could help in bone regeneration and growth. A wide range of material has been studied and examined to find the ideal combination. In this paper, a new blend of Tri-calcium phosphate (TCP), polycaprolactone (PCL) and bovine hydroxyapatite (BHA) was introduced to create scaffolds with fused deposition 3d printing. Effect of BHA concentration as a naturally derived and newcomer 3d printing material was investigated via FTIR, XRD, and SEM analyses. In vitro studies were exhibited that 15% (wt/wt) BHA fabricated composite scaffolds possessed more bioactivity than other cases with increasing proliferation and growth rates. © 2019 Elsevier B.V.Publication Metadata only Preparation and characterization of silver-doped hydroxyapatite from seashell by different methods(2018-09-08) AYAZ SEYHAN, SERAP; BİLĞİÇ ALKAYA, DİLEK; CESUR, SÜMEYYE; OKTAR, FAİK NÜZHET; GÜNDÜZ, OĞUZHAN; , Ayaz Seyhan S., Bilğiç Alkaya D., Öztürk B. N., Cesur S., Topsakal A., Oktar F. N., Gündüz O.Publication Metadata only Hydroxyapatıte is bıomaterıals: its chemıcal synthesıs characterızatıon shell of cypaea annulus(2018-09-08) BİLĞİÇ ALKAYA, DİLEK; AYAZ SEYHAN, SERAP; CESUR, SÜMEYYE; OKTAR, FAİK NÜZHET; GÜNDÜZ, OĞUZHAN; Bilğiç Alkaya D., Ayaz Seyhan S., Öztürk B. N., Cesur S., Topsakal A., Oktar F. N., Gündüz O.Publication Metadata only The natural nano-bioceramic powder production from organ pipe red coral (Tubipora musica) by a simple chemical conversion method(AUSTRALIAN CERAMIC SOCIETY, 2018) OKTAR, FAİK NÜZHET; Karacan, Ipek; Gunduz, Oguzhan; Ozyegin, L. Sevgi; Gokce, Hasan; Ben-Nissan, Besim; Akyol, Sibel; Oktar, Faik N.The marine species are especially suited for the production of bioceramic nano-powders with natural methods for their use in the biomedical field. However, there are only very limited studies regarding the production and synthesis of hydroxyapatite (HAp) and tricalcium phosphate (TCP) nanomaterials from the marine structures. The structure of coral is very unique due to its similarity to bone because their structure consists of calcium carbonate that is the precursor for the synthesis of HAp. In this research, nano-bioceramic powders were produced from the organ pipe red coral (Tubipora musica) by two different simple chemical conversion methods under two different synthesis methods rather than the common hydrothermal method. The main advantages of these two methods are that they are simple and more economical in comparison to other methods used. All samples were analyzed by X-ray diffraction (XRD) and scanning electron microscope (SEM), respectively. The size and shape of converted particles and structures were controlled by adjusting the calcination temperature and most importantly the agitation-mixing rate. According to XRD and SEM results, it can be concluded that the nano-scale monetite and other calcium phosphate powders were successfully obtained by these simple methods although retained calcium carbonate also observed due to the partial conversion.Publication Open Access Marine-derived bioceramics for orthopedic, reconstructive and dental surgery applications(2022-11-01) OKTAR, FAİK NÜZHET; ÜNAL YILDIRIM, SEMRA; GÜNDÜZ, OĞUZHAN; EKREN, NAZMİ; ALTAN, ERAY; OKTAR F. N. , Unal S., GÜNDÜZ O., Ben Nissan B., Macha I. J. , Akyol S., Duta L., EKREN N., ALTAN E., YETMEZ M.Bioceramics are a fast-growing materials group, which are widely used in orthopedics, maxillofacial, dental, and reconstructive surgeries. They are produced using raw materials either from synthetic or natural sources. As naturally originated resources, the bones of sheep and cows are used after converting to calcium phosphates. Human-originated sources in the past were obtained from human cadaver bones, however now-a-days this has been discontinued. On the other hand, the \"golden standard\" in the reconstruction surgery has been using patients own bones, -i.e., autogenous bones, which heal better than other alternatives. Besides natural products, synthetic materials are produced from a range of inorganic raw and natural materials based on marine sources, such as corals, and other marine-derived materials (i.e., seashells, nacre). These are used to produce bioceramics and hence implants, devices, and bone grafts. Although during the last four decades a number of excellent books and book chapters have been published, no comprehensive review has been yet reported to cover the available marine materials and to indicate the related work and corresponding references to allow for both medical and ceramic scientists to access directly and open new avenues for further research on marine structures and their applications in orthopedic, maxillofacial, and reconstructive surgery areas. Hence, this review covers the general marine structures, their locations and availability in different countries and, current research on production methods of these unique structures that are difficult to fabricate synthetically. The authors are confident that this comprehensive review will be an excellent source not only for the ceramists, but also for the medical scientists.