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İSLAMOĞLU, AYŞE HÜMEYRA

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İSLAMOĞLU

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AYŞE HÜMEYRA

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2016 - 20192
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End date: 2019 × Start date: 2016 ×

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    Evaluation of a Standardized Bakery Product (SUTMEK) as a Potential Tool for Baked-Milk Tolerance and Immunotherapy Research Studies
    (KARGER, 2019) ÖZEN, AHMET OĞUZHAN; Kiykim, Ayca; Karakoc-Aydiner, Elif; Gunes, Esra; Nain, Ercan; Ogulur, Ismail; Yazici, Duygu; Aktac, Sule; Bicer, Ayse Humeyra; Sackesen, Cansin; Baris, Safa; Ozen, Ahmet
    Background and Objectives: About 65-80% of children with IgE-mediated cow's milk allergy (CMA) can tolerate extensively heated milk. We have invested in the mass fabrication of a test product containing milk protein baked at 180 degrees C for 30 min (SUTMEK-milk) and a milk-free placebo (SUTMEK-placebo) to carry out a standardised double-blind placebo-controlled food challenge (DBPCFC) test in patients with CMA. Methods: We studied children with IgE-mediated CMA between 13 and 48 months of age. Specific IgEs (spIgE) to milk proteins were quantified. A DBPCFC with our bakery products was performed, and factors determining reactivity to extensively heated milk were evaluated. We also tested the applicability of SUTMEK products in baked-milk oral immunotherapy in a pilot assessment. Results: We studied 15 children (8 girls, 7 boys) with a median age of 26 months (range: 13-48 months). Nine (60%) patients tolerated a challenge with extensively heated milk, while 6 (40%) were found reactive (anaphylaxis: 2, wheezing: 2, urticaria: 2). spIgE to milk, alpha-lactalbumin, and casein, and the wheal diameter on skin prick testing were higher in the reactive group than the tolerant groups (p = 0.001, p = 0.001, p = 0.002, and p = 0.048, respectively). Receiver-operating characteristic curve analyses yielded the following cut-off values for spIgEs that would predict a reactivity to extensively heated milk; milk: 25 kU/L (area under curve, AUC: 0.981), casein: 32 kU/L (AUC: 0.983), and alpha-lactalbumin: 17 kU/L (AUC: 0.981). Nine patients have tolerated well a continued daily consumption of SUTMEK-milk or -placebo for 6 months at the desired doses. Conclusions: Our bakery products were successfully used in DBPCFC studies and qualified as an acceptable tool for use in the research of interventional tolerance induction. Although spIgE appears useful in determining children at high risk of reacting to extensively heated milk, the predictive cut-off values are still far from being perfect. (c) 2018 S. Karger AG, Basel
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    Dietary intake and physical activity levels of male adolescents with autism spectrum disorder (ASD) and normal to high body mass index (BMI) - A case series study
    (ELSEVIER SCI LTD, 2016) İSLAMOĞLU, AYŞE HÜMEYRA; Bicer, Ayse H.; Alsaffar, Ayten A.
    Background and objectives: The study aims to determine the daily energy and nutrient intake, eating behaviours and physical activity level of male adolescents with autism spectrum disorder (ASD) and normal to high body mass index (BMI)-for-age and compares them with an age-, gender- and BMI- matched group consisting of typically developing adolescents. Methodology: Anthropometric measures were taken from 118 male adolescents with ASD (12-18 years) and classified as normal-weight, overweight and obese according to BMI and 97 typically developing adolescents living in the same area. Participants completed a socio-demographic survey, feeding assessment survey, 24-h food recall and International Physical Activity Questionnaire (IPAQ). Results: Nutritional assessment of the adolescents with ASD and typical development revealed similar prevalence of inadequacy for most nutrients. Dietary fibre, vitamin D, calcium and folate were the main nutrients that the adolescents were taking inadequately. Intake levels of nearly all micronutrients were insufficient. Both groups consumed excess amounts of sodium and cholesterol. Energy intake of the normal-weight adolescents with ASD was significantly less than the other BMI categories. Energy intake and physical activity level (and their interaction) were found to be related to the BMI of the adolescents with ASD. No other factors studied seemed to explain the changes in the BMI. Conclusions: In terms of nutrient intake, male adolescents with ASD were not at a greater risk when compared to the typically developing counterparts. Diets of the both groups need to be improved. Meeting daily physical activity requirements could be as important as monitoring dietary intake in adolescents with ASD. (C) 2016 Elsevier Ltd. All rights reserved.