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TOKSOY ÖNER, EBRU

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TOKSOY ÖNER

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2012 - 201922020 - 20211
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    Rheological characteristics of exopolysaccharides (EPSs) produced by Brevibacillus thermoruber
    (ELSEVIER SCIENCE BV, 2012) TOKSOY ÖNER, EBRU; Yildiz, Songul Yasar; Ozer, Tugba; Radchenkova, Nadia; Genc, Seval; Oner, Ebru Toksoy; Kambourova, Margarita
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    Synthesis and characterization of levan hydrogels and their use for resveratrol release
    (SAGE PUBLICATIONS LTD, 2021) TOKSOY ÖNER, EBRU; Selvi, Sinem Selvin; Haskoylu, Merve Erginer; Genc, Seval; Toksoy Oner, Ebru
    Considering the need for systematic studies on levan based hydrogels to widen their use in drug delivery systems and biomedical applications, this study is mainly focused on the synthesis and comprehensive characterization as well as drug release properties of hydrogels based on Halomonas levan (HL) and its chemical derivatives. For this, hydrolyzed and phosphonated HL derivatives were chemically synthesized and then cross-linked with 1,4-Butanediol diglycidyl ether (BDDE) and the obtained hydrogels were characterized in terms of their swelling, adhesivity, and rheological properties. Both native and phosphonated HL hydrogels retained their rigid gel like structure with increasing shear stress levels and tack test analysis showed superior adhesive properties of the phosphonated HL hydrogels. Moreover, hydrogels were loaded with resveratrol and entrapment and release studies as well as cell culture studies with human keratinocytes were performed. Biocompatible and adhesive features of the hydrogels confirmed their suitability for tissue engineering and drug delivery applications.
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    Halomonas smyrnensis as a cell factory for co-production of PHB and levan
    (ELSEVIER SCIENCE BV, 2018) KASAVİ, CEYDA; Tohme, Souha; Haciosmanoglu, Gul Gulenay; Eroglu, Mehmet Sayip; Kasavi, Ceyda; Genc, Seval; Can, Zehra Semra; Oner, Ebru Toksoy
    Levan is a fructan type polysaccharide that has long been considered as an industrially important biopolymer however its limited availability is mainly due to the bottlenecks associated with its large-scale production. To overcome such bottlenecks in the commercialization of this very promising polysaccharide, co-production of levan with polyhydroxyalkanoates (PHAs) by halophilic Halomonas smyrnensis cultures has been proposed in this study for the first time. After in silico and in vitro assessment of PHA accumulation, fermentation profiles for levan and PHA concentrations were obtained in the presence of sucrose and glucose and the PHA granules observed by TEM were found to be poly(3-hydroxybutyrate) (PHB) after detailed structural characterization by GC-MS, DSC, FTIR and NMR. Six nutrient limitation strategies based on nitrogen (N) and phosphorus (P) were tested but highest levan and PHB yields were obtained under unlimited conditions. H. smyrnensis is proved to co-produce PHB and levan while using inexpensive carbon sources which is a commercially successful microbial cell factory system showing a great potential in lowering manufacturing costs and aiming for a zero waste policy within the biorefinery concept. (C) 2018 Elsevier B.V. All rights reserved.