Person: YILDIZ, MESUT
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YILDIZ
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MESUT
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Publication Open Access Suicide among doctors in Turkey: Differences across gender, medical specialty and the method of suicide(2023-03-01) YILDIZ, MESUT; HIDIROĞLU, SEYHAN; YILDIZ M., Batun K. D., Sahinoglu H., Eryilmaz M. S., Ozel B., Ataoglu B., HIDIROĞLU S.Background. Doctors have higher rates of mental illness and suicide than the general population worldwide. Suicides of doctors are known to be underreported in developing countries. To the best of our knowledge, there are no studies investigating suicides among medical students and doctors in Turkey.Objectives. To investigate the characteristics of suicides in medical school students and doctors in Turkey.Materials and methods. In this retrospective study, newspaper websites and Google search engine were searched for information on medical school student and doctor suicides in Turkey between 2011 and 2021. Cases of suicide attempt, parasuicide or deliberate self-harm were not included in the study.Results. Sixty-one suicides were reported between 2011-2021. There was a male predominance (45 (73.8%)), and more than half of the suicides (32 (52.5%)) occurred among specialist doctors. Self poisoning, jumping from heights and firearms were the most common methods of suicide (18 (29.5%), 17 (27.9%) and 15 (24.6%), respectively). Cardiovascular surgery, family medicine, gynecology, and obstetrics specialties had the highest numbers of suicide deaths. Depression/mental illness was the most common speculated etiology. These results show that suicides among medical students and doctors in Turkey have characteristics that differ from both suicided among the general population in Turkey and doctor suicides in other countries.Conclusions. In this study, we identified the suicidal characteristics of medical students and doctors in Turkey for the first time. The results help us to better understand this understudied topic and provide an avenue for future studies. The data also indicate that it is important to monitor the individual and systemic difficulties experienced by doctors, starting from the medical education stage, and to provide individual and environmental support to help decrease the risk of suicide.Publication Open Access The relationship between psychopathology and cognitive functions with cytokines in clinically stable patients with schizophrenia(TAYLOR & FRANCIS LTD, 2018-01-02) HAKLAR, GONCAGÜL; Ergun, Serhat; Yanartas, Omer; Kandemir, Guler; Yaman, Ali; Yildiz, Mesut; Haklar, Goncagul; Sayar, KemalOBJECTIVES: Inflammation and the cytokine hypotheses have been proposed for schizophrenia. Several proinflammatory and anti-inflammatory cytokines have been studied in drug-naive, first-episode, and/or chronic schizophrenia patients. However, there were limited data on clinical stable outpatients reflecting daily routine. The aim of this study was to compare the serum levels of cytokines, including transforming growth factor-beta (TGF-beta), interleukin-6 (IL-6), and tumour necrosis factor-alpha (TNF-alpha), between clinically stable patients with schizophrenia and healthy controls, as well as to examine the relationship between these inflammation parameters and clinical variables (positive and negative symptom severity and cognitive functions). METHODS: Thirty clinically stable outpatients with schizophrenia and 30 healthy controls with similar sex and age were included in this study. Serum IL-6, TGF-beta, and TNF-alpha levels were assessed by enzyme-linked immunosorbent assay (ELISA) and immunoenzyme microplate measurement, respectively. Illness severity was evaluated using the Positive and Negative Syndrome Scale (PANSS), and the cognitive functions of the participants were assessed using a broad neuropsychological test battery. RESULTS: The serum levels of IL-6 and TGF-beta were significantly higher in patients with schizophrenia compared to healthy controls (p = .048, p = .012). There was no significant difference between groups in terms of TNF-alpha levels (p = .726). Global impairment of cognitive functions was observed in the patient group compared to healthy controls, and PANSS scores and cognitive functions showed no correlation with cytokine levels (IL-6, TNF-alpha, and TGF-beta). CONCLUSIONS: The present study demonstrated an increased inflammatory response in clinically stable patients with schizophrenia compared to healthy controls. However, symptom severity and cognitive functions showed no correlation with cytokine levels. Further research studies are needed to clarify the effects of cytokine levels on schizophrenia symptomatology and etiopathogenesis.Publication Open Access Simple markers for subclinical inflammation in the different phases of bipolar affective disorder(UNIV SAO PAULO, INST PSIQUIATRIA, 2016-12) YILDIZ, MESUT; Yildiz, Mesut; Batmaz, Sedat; Songur, Emrah; Sahin, Safak; Demir, OsmanBackground: Recently, a growing number of publications have suggested that the immune-inflammatory system may be involved in the etiology of bipolar disorder (BD). Objective: The aim of this study was to investigate neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), and red cell distribution width (RDW) in the three different phases of BD patients compared to each other and controls. Methods: One hundred eighty-seven bipolar patients (78 euthymic, 53 manic/hypomanic and 56 depressed), and 62 age and sex matched controls were enrolled. Sociodemographic variables and complete blood count parameters of the patients and the control group were recorded. Results: The groups did not differ from each other on the hematological parameters, except for NLR and RDW. Post-hoc analyses revealed that NLR values were significantly higher in the euthymic and manic/hypomanic bipolar groups compared to control group. In addition, post-hoc analyses revealed that RDW values were significantly higher in the manic/hypomanic bipolar group relative to the control group. Discussion: Longitudinal studies evaluating the levels of inflammatory markers in the early phases of the disorder, and their relationship with the development of different episodes and medical comorbidities may be useful to understand the role of inflammation in BD.Publication Open Access Suicide Attempts in Turkish University Students: The Role of Cognitive Style, Hopelessness, Cognitive Reactivity, Rumination, Self-esteem, and Personality Traits(SPRINGER, 2020-12) YILDIZ, MESUT; Akpinar Aslan, Esma; Batmaz, Sedat; Yildiz, Mesut; Songur, EmrahSuicide is one of the major public health problems in young adults. Detecting the risk factors and correlates among university students might help identify students who are under risk and who need early interventions for suicide prevention. The current study aimed to investigate the cognitive style, self-esteem, hopelessness, rumination, cognitive reactivity, and personality characteristics of Turkish university students, who previously attempted suicide and who did not. A total of 355 university students (34 previous suicide attempters) were recruited for this study, and they completed the Ten-Item Personality Inventory (TIPI), the Ruminative Response Scale (RRS), the Leiden Index of Depression Sensitivity-Revised, the Beck Hopelessness Scale (BHS), the Cognitive Style Questionnaire-Short Form (CSQ), the Rosenberg Self-Esteem Scale (RSES), and the Hospital Anxiety and Depression Scale. Higher RRS, BHS, CSQ scores and lower TIPI-A and RSES scores were significantly associated with a previous suicide attempt. Negative cognitive style, hopelessness, and rumination were significant correlates of a previous suicide attempt. These cognitive factors may be targets in psychotherapy to reduce suicide attempts in college-age individuals.Publication Open Access Automatic thoughts, cognitive distortions, dysfunctional attitudes, core beliefs, and ruminative response styles in unipolar major depressive disorder and bipolar disorder: a comparative study(TAYLOR & FRANCIS LTD, 2019-10-02) YILDIZ, MESUT; Yesilyaprak, Nurgul; Batmaz, Sedat; Yildiz, Mesut; Songur, Emrah; Akpinar Aslan, EsmaOBJECTIVES: We aimed to compare patients with bipolar disorder and major depressive disorder, who were either in an acute depressive episode or in remission, and a healthy control group on their cognitions related to depression and mania/hypomania, and on their response styles. METHODS: A total of 300 participants who presented to our outpatient psychiatry department were included in the study (100 participants with unipolar depression (DG), 100 with bipolar disorder, and 100 with no previous or current psychiatric disorder (CG)). The participants completed the Cognition Checklist (CCL), the Cognition Checklist for Mania (CCL-M-R), the Cognitive Distortions Questionnaire (CDQ), the Dysfunctional Attitude Scale (DAS), the Hypomanic Attitudes and Positive Predictions Inventory (HAPPI), the Brief Core Schemas Scale (BCSS), Ruminative Response Scale (RRS), and the Responses to Positive Affect Questionnaire (RPAQ). The groups were compared with each other by one-way analysis of variance, independent samples t-test, and chi-square tests. RESULTS: The DG scored higher than the other groups on the CCL, the frequency and intensity subscales of the CDQ, the DAS, and the negative-self and negative-others subscales of the BCSS, the RRS, and on the dampening subscale of the RPAQ. The clinical groups scored higher than the CG on the scores of the relationships subscale of the CCL-M-R, the total score of the CDQ, and the HAPPI. The CG scored higher than the clinical groups on the positive-self subscale of the BCSS, and on the emotion focused positive rumination subscale. CONCLUSIONS: These findings are important in the differential diagnosis of mood disorders, and for their treatment with cognitive behavioural psychotherapy.Publication Open Access Neuropsychological and clinical correlations of optical coherence tomography findings in patients with schizophrenia(2023-10-01) SAKALLI KANİ, AYŞE; ŞAHİN ÇAM, CANSUN; AKKAYA TURHAN, SEMRA; TOKER, AYŞE EBRU; YILDIZ, MESUT; Sakallı Kani A., Şahin Çam C., Çelik E. B., Dural Şenoğuz U., Duran M., Akkaya Turhan S., Toker A. E., Yıldız M.Objective: There are increasing studies examining retinal fiber layer (RNFL) and ganglion cell layer (GCL) thinning in patients with schizophrenia. However, the results are controversial, and clinical and cognitive reflections of these findings remain unclear. With this study, we aim to examine retinal abnormalities and establish correlations with cognitive and clinical parameters. Methods: In this cross-sectional study, we examined 29 patients with schizophrenia and 13 age and gender-matched healthy controls. All participants underwent psychometric assessment, neuropsychological tests, and optical coherence tomography (OCT) measurements. The retinal fiber layer and ganglion cell layer thickness were used as retinal parameters. Results: Five patients dropped out during the OCT measurement process, 24 patients with schizophrenia and nine healthy controls were included in the analysis. There was no statistically significant difference between groups in measuring retinal nerve fiber layer or ganglion cell layer thicknesses. The verbal fluency test score negatively correlated with left RNFL superior (ρ = – .422, p <.05). STROOP response duration positively correlated with right RNFL on average (ρ = .551, p <.05), left RNFL on average (ρ = .498, p <.05), right RNFL superior (ρ = .507, p <.05), left RNFL superior (ρ = .461, p <.05) and right RNFL temporal values (ρ = .434, p <.05). STROOP response error was also positively correlated with right RNFL temporal thickness (ρ = .430, p <.05). STROOP response duration was positively correlated with right GCL total (ρ = .646, p <.01), right GCL superior (ρ = .658, p <.01) and right GCL inferior (ρ = .596, p <.01) thickness. Conclusion: We did not find a significant relationship between reduced RNFL or GCL thickness and cognitive impairment. However, we had several positive correlations between cognitive task scores and RNFL and GCL thicknesses. Additionally, our study did not correlate symptom severity and clinical severity parameters with reduced RNFL or GCL thicknessPublication Open Access Analysis of the psychiatric consultations for inpatients and from the emergency room in a university hospital: A comparison with studies from Turkey(KLINIK PSIKIYATRI DERGISI, 2018) YILDIZ, MESUT; Eser, Burcu; Batmaz, Sedat; Songur, Emrah; Yildiz, Mesut; Aslan, Esma AkpinarObjective: The aim of this research was to assess the characteristics of the consultations required in a psychiatric department of a university hospital, and the distribution of psychiatric disorders in hospitalized patients and patients admitted to the emergency room. Method: In the study, the data of 539 patients 18 years or older (48.67 +/- 20.91 years) (46.8% women) who were hospitalized and who presented to the emergency room between 01/01/2015 and 31/12/2015, and for whom a psychiatric consultation was requested were recorded onto a structured form. Patients' electronic databases were reviewed retrospectively for the specified date range. Descriptive statistical analyzes (frequency of data, distribution, mean, standard deviation) were performed for the data examined in the study. Results: Medical departments (42.9%), surgical departments (31.7%) and the emergency medicine department (25.4%) were the most frequently psychiatric consultation requesting departments. The most frequent requests for consultation were agitation (15.4%), depressive symptoms and signs (14.7%) and suicide attempts (12.2%). The most frequent psychiatric diagnoses were depressive disorders (19.5%), delirium (18.2%) and schizophrenia and other psychotic disorders (7.4%). Musculoskeletal diseases (17.4%), mental disorders (15.0%), oncologic diseases (14.1%) and suicide attempts (12.2%) were the primary diagnoses of patients. Discussion: Consultation and liaison psychiatry services have an important role in our relationship with other departments in medicine. Priority to training of depressive disorders, delirium and suicide attempts should be offered to healthcare providers working in these departments.Publication Open Access Paraoxonase (PON1) L55M and Q192R polymorphisms in major depression and bipolar affective disorder(UNIV SAO PAULO, INST PSIQUIATRIA, 2017-06) YILDIZ, MESUT; Yildiz, Mesut; Celikel, Feryal Cam; Ates, Omer; Taycan, Serap Erdogan; Benli, Ismail; Demir, OsmanBackground: Oxidative and nitrosative stress pathways, along with immune-inflammatory response, might play an important role in the pathogenic mechanisms underlying major depression and bipolar disorder. Objective: The aim of the present study is to investigate paraoxonase 1 polymorphisms and its correlations with disease parameters in patients with major depression and bipolar affective disorder. Methods: PON1 L55M and Q192R single nucleotide polymorphisms were analyzed in a group consisted of 100 patients with major depression, and 100 patients with bipolar affective disorder and 96 healthy controls. Polymorphisms were analyzed by using polymerase chain reaction. Results: Our findings reported no association between Q192R and L55M polymorphisms of PON1 and major depression and bipolar disorder. Additionally, there was no association between the PON1 genotypes and disease variables in both depressed and bipolar patients. Discussion: Evaluating the different stages of patients with affective disorders and and investigating the connection between PON1 polymorphisms and treatment outcomes will help us to clarify the relationship between PON1 and mood disorders.Publication Open Access The relationship between type d personality and impulsivity in medicine, dentistry, and nursing students(2023-05-01) YILDIZ, MESUT; Yıldız M.Amaç: D tipi kişilik negatif afektivite (NA) ve sosyal inhibisyonun (SI) belirgin olduğu bir kişilik tipi olarak tanımlanmaktadır. D tipi kişilik psikiyatrik semptomlarla ilişkilidir. Bu çalışmanın amacı klinik olmayan bir popülasyonda Tip D kişilik ile dürtüsellik arasındaki ilişkinin araştırılmasıdır. Gereç ve Yöntem: Çalışmaya toplamda sağlık alanında eğitim gören 462 üniversite öğrencisi dahil edilmiştir. Katılımcılara Beck Anksiyete Ölçeği (BAI), Beck Depresyon Ölçeği (BDI), Barratt Dürtüsellik Ölçeği-11 (BIS-11) ve D Tipi Kişilik Ölçeği (DS-14) ile değerlendirilmiştir. Bulgular: D tipi kişiliğin sıklığı % 39.6 idi. D tipi kişiliği olanlarda olmayanlarda göre BAI, BDI ve BIS ölçek skorları daha yüksek bulunmuştur. Korelasyon analizinde D tipi kişiliğin depresyon ve anksiyetenin şiddetiyle pozitif olarak korele olduğu gösterilmiştir. BIS ile ölçülen dürtüsellik skorlarının D tipi kişilik, depresyon ve anksiyete skorları ile pozitif yönde korele oldukları görülmüştür. Regresyon analizinde ise dürtüselliğin erkek cinsiyet ev depresyon skorları ile predikte edildiği gösterilmiştir. Sonuç: D tipi kişiliğik depresyon ve anksiyete şiddetiyle koreledir. Depresyon puanları ve erkek cinsiyet dürtüselliği yordamaktadır