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GÜNDÜZ, OĞUZHAN

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GÜNDÜZ

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OĞUZHAN

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2023 - 20242
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Author: ULAĞ, SONGÜL × Subject: Engineering, Computing & Technology (ENG) ×

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    PublicationOpen Access
    3D-printed polylactic acid (PLA)/polymethyl silsesquioxane (PMSQ)-based scaffolds coated with vitamin E microparticles for the application of wound healing
    (2024-05-01) ULAĞ, SONGÜL; GÜNDÜZ, OĞUZHAN; Anjrini N., Karabulut H., Ulağ S., Ege H., Noberi C., Dogan E., Sahin A., Gündüz O.
    Skin is part of the integumentary and excretory system, which helps protect the body against infections. The skin should be properly treated when it gets injured, which requires a long healing process. In this study, 15% (w/v) polylactic acid (PLA) and 1 and 2% (w/v) polymethylsilsesquioxane (PMSQ) scafolds were fabricated using 3D printing technology, and the surfaces of each scafold were coated with 5% ethylcellulose (EC)/vitamin E microparticles using the electrospray method. The morphologies of the scafolds were characterized using a scanning electron microscope (SEM), and results showed that the pore sizes of the scafolds ranged from 136 to 265μm. The vitamin E was completely released from the scafolds within 5h. MTT test was performed with fbroblast cells and results proved the biocompatibility of the scafolds. These fndings showed that the scafolds may have good potential as a wound dressing material. The biodegradation test was performed in invitro conditions and results showed that the surface coating with 5% EC/vitamin E microparticles on the 15% PLA/2% PMSQ scafolds increased the degradation rate of the scafolds.
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    PublicationOpen Access
    Recent advances in health biotechnology during pandemic
    (2023-06-01) GÜNDÜZ, OĞUZHAN; ULAĞ, SONGÜL; ARI Yuka S., Akpek A., Özarslan A., Vural A., Koçer A. T., ASLAN A., Karaaltin A. B., Gök B., Yilmaz B. B., İNAN B., et al.
    The outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which emerged in 2019, cut the epoch that will make profound fluctuates in the history of the world in social, economic, and scientific fields. Urgent needs in public health have brought with them innovative approaches, including diagnosis, prevention, and treatment. To exceed the coronavirus disease 2019 (COVID-19) pandemic, various scientific authorities in the world have procreated advances in real time polymerase chain reaction (RT-PCR) based diagnostic tests, rapid diagnostic kits, the development of vaccines for immunization, and the purposing pharmaceuticals for treatment. Diagnosis, treatment, and immunization approaches put forward by scientific communities are cross-fed from the accrued knowledge of multidisciplinary sciences in health biotechnology. So much so that the pandemic, urgently prioritized in the world, is not only viral infections but also has been the pulsion in the development of novel approaches in many fields such as diagnosis, treatment, translational medicine, virology, microbiology, immunology, functional nano- and bio-materials, bioinformatics, molecular biology, genetics, tissue engineering, biomedical devices, and artificial intelligence technologies. In this review, the effects of the COVID-19 pandemic on the development of various scientific areas of health biotechnology are discussed.