Person: UMUROĞLU, TÜMAY
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UMUROĞLU
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TÜMAY
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Publication Metadata only Effects of multiple pulmonary aspirations of enteral solutions on lung tissue damage(CHURCHILL LIVINGSTONE, 2006) YILDIZELİ, BEDRETTİN; Umuroglu, T; Takil, A; Irmak, P; Yildizeli, B; Ahiskali, R; Dogan, V; Gogus, FYBackground Et aim: The aim of this study was to compare the pulmonary histopathologic effects of enteral solutions with various lipid content, after multiple aspirations in rats. Methods: Thirty Wistar albino rats were randomly assigned to one of three groups (n = 10). Salinesolution (0.9%) (group C, control), Impact (lipid content, 28g/l; group I), Pulmocare (lipid content, 93.3g/l; group P) were injected into the lung through the trachea, in a volume of 0.8 ml/kg. The aspiration procedure was performed three times in total, in every 2 days. After seven days from the first aspiration, rats were killed, and lungs were examined for histopathologic examination. Results: Alveolar histiocytes were statistically higher in left lungs of the group I than the left ones of the control group(P < 0.05). Lipid-laden alveolar macrophages were significantly higher in left lungs of groups I and, P than left lungs of the control group (P < 0.05). Conclusion: Lung tissue damage occuring after multiple pulmonary aspirations of Impact and Pulmocare, is histopathotogically similar to each other, and is in the form of lipoid pneumonia. In cases of multiple pulmonary aspirations, volume of the aspirate and chronicicity of the aspiration took like major impact factors rather than the amount of the lipid. (c) 2005 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.Publication Metadata only The effect of propofol and alfentanil on the increase in intraocular pressure due to succinylcholine and intubation(WICHTIG EDITORE, 2000) UMUROĞLU, TÜMAY; Eti, Z; Yayci, A; Umuroglu, T; Gogus, FY; Bozkurt, NPURPOSE. The aim of this study was to evaluate the effects of propofol and alfentanil on the increase in intraocular pressure (IOP) due to succinylcholine and intubation, in comparison with thiopental sodium and vecuronium bromide. METHODS. Forty patients aged 20-50 years, scheduled for elective surgery requiring endotracheal intubation, were assigned to four groups of ten. General anesthesia was induced with 2.5 mg/kg propofol in Group 1, 2.5 mg/kg propofol and 10 mu g/kg alfentanil in Group II and 5 mg/kg thiopental in Groups III and IV muscle relaxation was obtained with either 1.5 mg/kg succinylcholine (Group I, II and III) or 0.1 mg/kg vecuronium bromide (Group IV). In all patients mean arterial pressure, heart rate, oxygen saturation and IOP were recorded before (baseline) and after induction, after the muscle relaxant and after endotracheal intubation. RESULTS. Compared with their baseline values in Group I IOP decreased significantly after propofol (p<0.01) and increased significantly after intubation (p<0.01). In Group II IOP decreased significantly after propofol and alfentanyl (p<0.001), remained low after succinylcholine (p<0.01) and did not change after intubation. In Group III IOP decreased significantly after thiopental (p<0.001) and increased significantly after intubation (p<0.001). In Group IV ii decreased significantly after thiopental (p<0.001), remained low after vecuronium (p<0.001) and increased significantly after intubation (p<0.05). CONCLUSIONS. In all Groups, IOP did not increase significantly after succinylcholine, but only anesthesia induced with propofol and alfentanil prevented the increase in IOP due to intubation.Publication Metadata only Analgesia for adeno tonsillectomy in children: a comparison of morphine, ketamine and tramadol(WILEY, 2004) UMUROĞLU, TÜMAY; Umuroglu, T; Eti, Z; Ciftci, H; Gogus, FYBackground: Establishment of good analgesia is of major concern in the postoperative period following adenotonsillectomy. The aim of this study was to compare the effects of ketamine, morphine and tramadol on postoperative pain after adenotonsillectomy in children. Methods: Sixty children (age 5-12 years) scheduled for adenotonsillectomy were randomized into four groups to receive intravenously (i.v) either 0.5 mg(.)kg(-1) ketamine hydrochloride (K), 0.1 mg(.)kg(-1) morphine hydrochloride (M), 1.5 mg(.)kg(-1) tramadol hydrochloride (T) or normal saline (S) in a volume of 4 ml during induction. After tracheal intubation 10 mug(.)kg(-1.)min(-1) ketamine hydrochloride in group K and 0.6 ml(.)kg(-1.)h(-1) saline i.v. in groups M, K and S were infused per-operatively. Postoperative analgesic requirements and side-effects were recorded. Pain was assessed by the Numeric Rating Scale (NRS) and the Children's Hospital of Eastern Ontario Pain Scale (CHEOPS) scores. Results: Heart rate increased significantly peroperatively only in group K. NRS at first and fifth minute in group M and at first minute in group T and K and CHEOPS score at first, fifth, 15th and 60th min in group M were found to be significantly lower than in the control group. The time to first analgesic requirement was significantly longer in group M compared with ketamine and the control group. Six children in group M, nine in group T, 11 in group K and 15 in group S needed additional analgesics. Conclusions: Morphine hydrochloride 0.1 mg(.)kg(-1) i.v. administered during induction of anaesthesia provides efficient pain relief in children undergoing adenotonsillectomy.Publication Metadata only Histopathologic effects of lipid content of enteral solutions after pulmonary aspiration in rats(2003) YILDIZELİ, BEDRETTİN; Takil, Arzu; Umuroğlu, Tümay; Göğüş, Yilmaz Fevzi; Eti, Zeynep; Yildizeli, Bedrettin; Ahiskali, RenginOBJECTIVE: We compared the pulmonary histopathologic effects of different enteral formulas with various lipid contents during the subacute period of aspiration in rats. METHODS: Fifty Wistar albino rats, weighing 180 to 300 g, were randomly assigned to one of five groups (n = 10). Anesthesia was induced with an intraperitoneal injection of 100 mg/kg of ketamine hydrochloride, rats were intubated endotracheally with a 16-gauge angiocatheter, and 0.9% saline (group 1, control), Impact (group 2), Jevity (group 3), Biosorb Energy Plus (group 4), or Pulmocare (group 5) with a lipid content of 0, 28, 39.3, 58, or 93.3 g/L, respectively, was injected into the lungs in a volume of 3 mL/kg. Seven days later, rats were killed, and lungs with trachea were removed en bloc for histopathologic examination. For histopathologic assessment, slides were examined for the presence of peribronchial inflammatory cell infiltration, alveolar septal infiltration, alveolar edema, alveolar exudate, alveolar histiocytes, interstitial fibrosis, granuloma, and necrosis formation. The degree of severity was assessed by using a 4-point scale. One-way analysis of variance and Student-Newman-Keuls test were used for statistical analysis. RESULTS: Peribronchial inflammatory cell infiltration was present in all groups but was significantly more severe in group 2 than in groups 1, 4, and 5 (P < 0.05). Alveolar edema was statistically higher in group 2 than in group 1 (P < 0.05). Alveolar septal infiltration was statistically higher in group 4 than in group 1. Alveolar histiocytes were statistically higher in groups 2 and 3 (P < 0.01) and groups 4 and 5 (P < 0.05) than in group 1. Alveolar exudate, interstitial fibrosis, granuloma, and necrosis formation were absent in all groups. CONCLUSION: The pulmonary histopathologic effects of aspiration of Impact were severe peribronchial inflammatory cell infiltration (greater than aspiration of Biosorb and Pulmocare), abundant alveolar histiocytes, and alveolar edema in comparison with aspiration of saline, even though Impact had the lowest lipid content of all studied formulas. We concluded that the tissue damage occurring after pulmonary aspiration of Impact is more severe than after aspiration of Pulmocare.