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UMUROĞLU, TÜMAY

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UMUROĞLU

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TÜMAY

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End date: 2009 × Subject: ANESTHESIA ×

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    The effect of propofol and alfentanil on the increase in intraocular pressure due to succinylcholine and intubation
    (WICHTIG EDITORE, 2000) UMUROĞLU, TÜMAY; Eti, Z; Yayci, A; Umuroglu, T; Gogus, FY; Bozkurt, N
    PURPOSE. The aim of this study was to evaluate the effects of propofol and alfentanil on the increase in intraocular pressure (IOP) due to succinylcholine and intubation, in comparison with thiopental sodium and vecuronium bromide. METHODS. Forty patients aged 20-50 years, scheduled for elective surgery requiring endotracheal intubation, were assigned to four groups of ten. General anesthesia was induced with 2.5 mg/kg propofol in Group 1, 2.5 mg/kg propofol and 10 mu g/kg alfentanil in Group II and 5 mg/kg thiopental in Groups III and IV muscle relaxation was obtained with either 1.5 mg/kg succinylcholine (Group I, II and III) or 0.1 mg/kg vecuronium bromide (Group IV). In all patients mean arterial pressure, heart rate, oxygen saturation and IOP were recorded before (baseline) and after induction, after the muscle relaxant and after endotracheal intubation. RESULTS. Compared with their baseline values in Group I IOP decreased significantly after propofol (p<0.01) and increased significantly after intubation (p<0.01). In Group II IOP decreased significantly after propofol and alfentanyl (p<0.001), remained low after succinylcholine (p<0.01) and did not change after intubation. In Group III IOP decreased significantly after thiopental (p<0.001) and increased significantly after intubation (p<0.001). In Group IV ii decreased significantly after thiopental (p<0.001), remained low after vecuronium (p<0.001) and increased significantly after intubation (p<0.05). CONCLUSIONS. In all Groups, IOP did not increase significantly after succinylcholine, but only anesthesia induced with propofol and alfentanil prevented the increase in IOP due to intubation.
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    Analgesia for adeno tonsillectomy in children: a comparison of morphine, ketamine and tramadol
    (WILEY, 2004) UMUROĞLU, TÜMAY; Umuroglu, T; Eti, Z; Ciftci, H; Gogus, FY
    Background: Establishment of good analgesia is of major concern in the postoperative period following adenotonsillectomy. The aim of this study was to compare the effects of ketamine, morphine and tramadol on postoperative pain after adenotonsillectomy in children. Methods: Sixty children (age 5-12 years) scheduled for adenotonsillectomy were randomized into four groups to receive intravenously (i.v) either 0.5 mg(.)kg(-1) ketamine hydrochloride (K), 0.1 mg(.)kg(-1) morphine hydrochloride (M), 1.5 mg(.)kg(-1) tramadol hydrochloride (T) or normal saline (S) in a volume of 4 ml during induction. After tracheal intubation 10 mug(.)kg(-1.)min(-1) ketamine hydrochloride in group K and 0.6 ml(.)kg(-1.)h(-1) saline i.v. in groups M, K and S were infused per-operatively. Postoperative analgesic requirements and side-effects were recorded. Pain was assessed by the Numeric Rating Scale (NRS) and the Children's Hospital of Eastern Ontario Pain Scale (CHEOPS) scores. Results: Heart rate increased significantly peroperatively only in group K. NRS at first and fifth minute in group M and at first minute in group T and K and CHEOPS score at first, fifth, 15th and 60th min in group M were found to be significantly lower than in the control group. The time to first analgesic requirement was significantly longer in group M compared with ketamine and the control group. Six children in group M, nine in group T, 11 in group K and 15 in group S needed additional analgesics. Conclusions: Morphine hydrochloride 0.1 mg(.)kg(-1) i.v. administered during induction of anaesthesia provides efficient pain relief in children undergoing adenotonsillectomy.