Person:
AKICI, AHMET

Profile Picture

Email Address

Birth Date

Research Projects

Organizational Units

OrgUnit Logo
Organizational Unit

Job Title

Last Name

AKICI

First Name

AHMET

Name

Filters

2020 - 202429
Reset filters

Settings

End date: 2024 × Start date: 2020 ×

Search Results

Now showing 1 - 10 of 29
  • Thumbnail Image
    PublicationOpen Access
    Kardiyovasküler komorbiditesi bulunan ve bulunmayan esansiyel hipertansiyon hastalarında ilaç kullanımının araştırılması
    (2020) AKICI, AHMET; Dilara BAYRAM;Volkan AYDIN;Orkun Celil SEL;Ali serdar FAK;Mehmet Sait AKMAN;Zehra Aysun ALTIKARDEŞ;Ahmet AKICI
    Amaç: Hipertansiyon, komorbiditesi sık bir hastalık olup bu durum tedaviyidüzenlenmede belirleyicidir. Bu çalışmada hipertansif hastalarda başkakardiyovasküler sorunların olup olmama durumuna göre ilaç kullanımınınincelenmesi amaçlandıGereç ve Yöntem: Bu retrospektif çalışmaya Türk Kalp Vakfı Tıp Merkezi’ninOcak 2016-Haziran 2018 arasındaki hasta verileri dahil edildi (n=11.085).Hastalara ait kayıtlı tanılar içerisinde (n=26.699) en sık karşılaşılan üç tanı olanhipertansiyon (HT), iskemik kalp hastalığı (İKH) ve dislipidemi (DL)bulunanların tedavilerindeki ilaçlar, tıbbi ve demografik özelliklerideğerlendirildi. Hipertansiyon verileri ile buna eşlik eden İKH ve DL verilerikarşılaştırıldı.Bulgular: Çalışma periyodunda oluşturulan protokollerin %22,2’sini (n=5929)HT oluşturmaktaydı. Toplam 3601 HT tanılı hastanın %43,7’sini (n=1572) tektanılı olanlar, %36,7’sini ise (n=1321) eşlik eden iki komorbiditenin en az biriniiçeren hastalar oluşturuyordu. İncelenen tüm tanı gruplarında en sık karşılaşılanilaç asetilsalisilik asit idi. En sık karşılaşılan antihipertansif ana ilaç grubu reninanjiyotensin sistemi (RAS) blokerleri, etkin maddeler ise metoprolol veamlodipin idi. Bunu tek başına HT ve HT’ye DL’nin eşlik ettiği grupta“valsartan+hidroklorotiyazid”, İKH’nin eşlik ettiği gruplarda ramipril izliyordu.Beta-bloker kullanımı ≥65 yaş hastalarda genç hastalara kıyasla daha düşüktü(sırasıyla %13,8 ve %16,1, p<0,05).Sonuç: Bu çalışmada en çok tercih edilen antihipertansif grubun, anjiyotensinreseptör blokerlerinin baskınlığında, RAS üzerinden etkililer, en çok tercih edilenilacın ise metoprolol olduğu göze çarpmaktadır. Son yıllardaki kılavuzlarda betabloker kullanımının nispeten geri plana düşmüş olmasına rağmen, bu çalışmadahipertansif hastalarda yaygın olarak kullanıldığı görülmektedir. Hipertansiyonaeşlik eden iki durumda da en sık kullanılan ilaçların genel olarak değişkenlikgöstermediği anlaşılmaktadır.
  • No Thumbnail Available
    PublicationMetadata only
    Investigation of vitamin utilization in primary care in Istanbul
    (2020-10-12) AKICI, AHMET; ATAÇ Ö., AYDIN V., Kiraci H., AKICI A.
  • No Thumbnail Available
    PublicationMetadata only
    Knowledge, opinions and attitudes of primary care physicians about generic drugs: a cross-sectional study
    (OXFORD UNIV PRESS, 2021) AKICI, AHMET; Oncu, Seyma; Bayram, Dilara; Aydin, Volkan; Isli, Fatma; Aksoy, Mesil; Akici, Ahmet; Ucku, Reyhan; Gelal, Ayse
    Background: Generic drug (GD) use is affected by many factors, including physicians' approach. Objective: This study aimed to investigate the knowledge, opinions and attitudes of primary care physicians (PCPs) about GDs and potentially associated factors. Methods: An adequately representative sample (n = 354) of PCPs was determined via stratified and simple random sample selection method in this descriptive, cross-sectional study.The research data were collected through a face-to-face 40-item survey, where the knowledge, opinions and attitudes about GDs were questioned. The prescribing percentage of GDs overall was also examined. Results: The survey was completed by 305 PCPs (mean age: 49.2 +/- 7.9 years; 57.4% male). The rate of correct responses about GDs was 67.6% for basic knowledge and 46.6% for the development process. The percentages of PCPs who declared that GDs were 'less efficacious', 'of lower quality' and 'less safe' than original drugs were 65.2%, 53.4% and 35.4%, respectively. More than half (60.3%) of the PCPs declared not to pay attention to whether the drug is generic while prescribing. It was observed that, as the knowledge level of the physicians increased, negative opinions and prescribing attitudes regarding the effectiveness, quality and safety of the GDs decreased.The rate of GD prescribing (51.6%) in Izmir was lower than the rest of the country (54.6%; P < 0.001). Conclusion: This study shows that the knowledge of PCPs about GDs is generally inadequate, which reflects negatively on their opinions and attitudes regarding the use of GDs. Educational activities can help establish awareness that GDs can be used without doubt of their effectiveness, quality and safety.
  • No Thumbnail Available
    PublicationMetadata only
    Utilization of Injectable Drugs for Communicable and Non-communicable Diseases in Primary Healthcare: A Retrospective Study in Turkey
    (2023-03-01) AKICI, AHMET; Colak S. T., Vizdiklar C., AYDIN V., AYAZ B., Alkan A., AKICI A.
    Objective: Primary care, which is often the first level of contact for patients with various communicable diseases (CDs) and noncommunicable diseases (NCDs), might exhibit patterns of injectable drug utilization different from hospitals. We aimed to examine injection prescribing to adults with CD or NCD in primary care.
  • Thumbnail Image
    PublicationOpen Access
    The association of chiral characteristic with drug withdrawal due to safety: A comparative analysis
    (2022-08-01) AKICI, AHMET; Aydin V., Bahar A., Vizdiklar C., AKICI A.
    Aims Chirality of drugs might be associated with safety issues through pharmacokinetic or pharmacodynamic variations, interactions, or direct toxicological responses. We aimed to compare chiral status of the available drugs to that of drugs withdrawn due to adverse drug reactions (ADRs). Methods We searched the literature regarding withdrawn drugs due to safety-related issues (n = 391) to compare them with all available small-molecule drugs (n = 1633). We examined their chiral status and assigned as achiral compound, chiral mixture or pure enantiomer. We compared the mean survival (i.e., nonwithdrawal) time and withdrawal rates of drugs by their chirality, with further stratification by the launch year, ATC-1 (Anatomical Therapeutic Chemical) level and ADR. Results We identified higher withdrawal rate in achiral drugs (hazard ratio 2.1, 95% CI: 1.6-2.7) and chiral mixtures (hazard ratio 2.6, 95% CI: 1.9-3.5) compared to that in pure enantiomers. Pure enantiomers had the longest mean survival time (62.4 +/- 0.8 years), followed by achiral drugs (55.4 +/- 0.9 years, P < .01) and chiral mixtures (52.4 +/- 1.4 years, P < .01). Pure enantiomers had higher survival rates than chiral mixtures if launched before 1941 (P = .02), in 1961-1980 (P < .001) or 1981-2000 (P < .001). Pure enantiomers had lower withdrawal rate (18.2%) vs. chiral mixtures (35.1%, P = .02) in nervous system drugs. Pure enantiomers had lower withdrawal rate than chiral mixtures in hepatotoxic (P < .01) and cardiovascular ADRs (P < .01). Conclusion Our study showed lower likelihood of withdrawal for pure enantiomers compared to that in chiral mixtures and achiral drugs, which was more remarkable for those launched in certain time periods and several ADRs, including hepatotoxicity and cardiovascular toxicity.
  • No Thumbnail Available
    PublicationMetadata only
    Investigation of injectable drug utilization in primary care: A focus on different age groups in pediatric population
    (ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER, 2020) AKICI, AHMET; Akici, N.; Aydin, V; Donertas, B.; Alkan, A.; Akici, A.
    Objective: The suitability of the injectables may vary across different age groups especially for children; therefore, knowledge on their usage patterns is critical in terms of rational pharmacotherapy. This study aimed to investigate pediatric injectable drug utilization in primary care with a focus on different age groups. Method: By simple sampling method, 100 prescriptions that contained at least one injectable drug were randomly selected for each month of the year in 32 provinces of Turkey (n = 38 .400). Among these prescriptions, injectable drugs that were for children (< 18 years) were analyzed. Patterns of injectable drug utilization were compared according to the pediatric age group of infants, children, and adolescents. Results: We identified 5446 patients (14.2%) with a mean age of 7.4 +/- 5.2 years and a slight male tendency in distribution (53.8%). The most common indication for these patients was for the respiratory system (65.4%), of which 96.3% were respiratory tract infections. While less pronounced in adolescents than in infants and children, the most commonly prescribed injectable drugs were antibiotics in all age groups (61.5% vs. 78.6% and 79.9%, P < 0.0001), which was upheld across all seasons. More than 90% of all prescribed injectable antibiotics consisted of penicillins and cephalosporins; the latter being predominant in infants (67.4%) compared with penicillins in children (53.9%) and adolescents (59.0%). Analgesics and insulin were found to be prescribed more frequently to adolescents than they were to infants and children (P < 0.0001 and P < 0.0001, respectively). The mean cost of prescription and injectable drugs per encounter was significantly more likely to escalate with increasing age (P < 0.0001 and P < 0.0001, respectively). Conclusion: Considering the predominance of antibiotics as well as the substantially higher prescription of third-generation cephalosporins in primary care, which was especially more marked for younger children, our study indicates an inappropriate use of injectable drugs by primary care physicians for managing medical conditions in the pediatric population. (C) 2020 French Society of Pediatrics. Published by Elsevier Masson SAS. All rights reserved.
  • No Thumbnail Available
    PublicationMetadata only
  • Thumbnail Image
    PublicationOpen Access
    Investigation of prescribing trends and prescriptions for common diagnoses in primary care: Nationwide data of Turkey
    (CUKUROVA UNIV, FAC MEDICINE, 2020-06-30) AKICI, AHMET; Bayram, Dilara; Vizdiklar, Caner; Aydin, Volkan; Isli, Fatma; Akici, Ahmet
    Purpose: This study aimed to examine the details of prescriptions issued in primary care and the changes over the years in Turkey. Materials and Methods: We analyzed all electronic prescriptions registered to Prescription Information System by primary care physicians in Turkey between 2013 and 2016. The mean number of drugs per prescription (nDPP) was determined by patients' sex and age groups. The percentages of the prescriptions containing the top twenty most frequently encountered drugs were determined for each year of the study. In the four-year period, the percentage of prescriptions with the ten most common diagnoses among prescriptions with single diagnosis and nDPP were examined. Results: A total of 1.457.034.275 drugs were prescribed in 518.335.821 prescriptions and nDPP was 2.81 for the four-year period. The most commonly used drugs in all prescriptions were other cold preparations (19.2-19.7%) and amoxicillin+beta-lactamase inhibitor (9.9-10.5%). The diagnosis of hypertension (6.9%, nDPP: 2.00) and acute upper respiratory tract infection, unspecified (URTI), (6.5%, nDPP: 2.61) were in the top ranks in single-diagnosis prescriptions during four-year period. Conclusion: Primary care prescriptions appear to be mostly generated for women and elderly populations, with a tendency for URTI and hypertension indications. Overprescriptions of cold preparations, NSAIDs, PPIs, analgesics, and broad-spectrum antibiotics imply existence of important problems in the primary care regarding rational prescribing behavior.
  • No Thumbnail Available
    PublicationMetadata only
    Supratherapeutic utilization of paracetamol versus ibuprofen among <12-year-old children in primary care in Istanbul
    (2023-03-01) AKICI, AHMET; BAYRAM D., Vizdiklar C., Aydin V., Akici N., Atac O., AKICI A.
    Background Paracetamol and ibuprofen are the most preferred analgesics for pain and fever management in children. Prescribing of these drugs in supratherapeutic doses may predispose to their toxicity. We aimed to compare prescribing patterns and potential overdosing of paracetamol and ibuprofen in primary care for Methods We analysed paracetamol- and ibuprofen-containing prescriptions (PCPs, n = 173,575 and ICPs, n = 145,655) of 1- to 11-year-old children, issued by 3:1 systematically sampled primary care physicians (n = 1,431) in Istanbul during 2016. We compared drug use parameters and prescriptions surpassing daily and single-use dose limits for paracetamol and ibuprofen. Results We identified that 29.9% of PCPs and 20.8% of ICPs were generated for those aged 1-2 years. Concomitant analgesic use was higher in ICPs than in PCPs (15.1% vs. 12.8%). We found that 4.4% of PCPs and 3.1% of ICPs exceeded maximum daily dose limit of paracetamol and ibuprofen, respectively (P < 0.001). This was more common in girls (5.1% and 3.3%, respectively) and at 1 year of age in both groups (9.2% and 8.5%, respectively). Single-use supratherapeutic dosing was encountered in 16.5% of PCPs and 13.2% of ICPs (P < 0.001, pessimistic model) and in 8.6% of PCPs and 10.6% of ICPs (P < 0.001, optimistic model). Conclusions Paracetamol and ibuprofen were generally used in primary care for similar clinical conditions with subtle differences. However, more pronounced in younger children and girls, potential overdosing seems to be more practiced for paracetamol than ibuprofen both in terms of maximal daily and single-use setting.
  • Thumbnail Image
    PublicationOpen Access
    Investigation of Warnings Regarding Driving and Machine Use in Summary of Product Characteristics and Patient Information Leaflets of Drugs Frequently Used in Psychiatry
    (GAZI UNIV, FAC MED, 2020-01-01) AKICI, AHMET; Bayram, Dilara; Aydin, Volkan; Akici, Ahmet
    Objective: This study aimed to investigate details of warnings about effects on ability to drive and use machines in the summary of product characteristics (SmPC) and patient information leaflet (PIL) of the drugs that are frequently used in psychiatry and have expected and undesirable effects in central nervous system. Methods: Current SmPCs/PILs of the ten most commonly prescribed drugs in Turkey were examined in detail. The information under the subheadings of effects on ability to drive and use machines in SmPC and driving and using machines in PILs was assessed in at least two different time periods via standard evaluation criteria. Results: SmPCs/PILs of 409 generic drugs were examined. While 80.2% of these generics had same warnings as their reference drugs, major differences were found in 8.3% of SmPCs and 8.1% of PILs, compared to that of originals. The active ingredients with major differences in SmPCs included venlafaxine (47.8%), risperidone (34.0%), sertraline (22.2%), and paroxetine (5.6%) whereas those having major differences in their PILs were paroxetine (72.2%), mirtazapine (52.0%), sertraline (22.2%) and venlafaxine (13.0%). Except paroxetine, all examined active ingredients were found to have consistent SmPCs and PILs in their warnings about driving and machine use. Conclusion: Although SmPCs/PILs of examined drugs overall seem compatible regarding the warnings of driving and machine use, it is noteworthy that warnings in SmPCs/PILs of considerable amount of reference drugs differed from their generics. The study findings indicate the need for a more rigorous approach to the standardization of the content within the SmPCs/PILs.