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GÜLPINAR, MEHMET ALİ

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MEHMET ALİ

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Author: ALİCAN, YAŞAR İNCİ × Has files: false ×

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    Hypertension module: An interactive learning tool in physiology
    (AMER PHYSIOLOGICAL SOC, 2003) KURTEL, HIZIR; Isman, CA; Gulpinar, MA; Kurtel, H; Alican, I; Yegen, BC
    The aim of the present study was to evaluate the strong or weak aspects of an interactive study module introduced during the Cardiovascular and Respiratory Systems Subject Committee in the second year of the medical program. Five study groups consisting of 25 students attended two-hour module sessions for six weeks with the same tutor. According to the module assessment questionnaire, the majority of the students assessed the module as excellent or good. The students reported that they had gained not only in knowledge but also in skills development. The general opinion of the students was that both the organization and the implementation of the module met their expectations. Nearly one-half of the students reported that their expectations with regard to the educational environment and the participation of students were fully met. The major weakness in this new educational trial appears to be assessment of the module.
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    Beneficial effects of glycocholic acid (GCA) on gut mucosal damage in bile duct ligated rats
    (2001) ERCAN, FERİHA; Oktar, B. K.; Gülpinar, M. A.; Ercan, F.; Cingi, A.; Alican, I.; Yegen, B. C.
    In order to investigate the effect of bile acids on gastrointestinal inflammations, bile duct ligated rats (BDL) were treated with GCA (25 mM/ml, oral or colonic) or saline I h before ethanol challenge and twice daily for 3 days in the ileitis group, while GCA was given twice daily for 3 days in the colitis group. BDL reduced the macroscopic and microscopic damage scores in the ileitis group compared to sham operated group, while it had no significant effect on ulcer or colitis groups. However, GCA given in BDL group reduced the ulcer index and microscopic damage in colitis group compared to saline-treated groups, but had no effect in ileitis group. Both BDL and GCA administration in BDL group reduced ileitis- or colitis-induced elevations in MPO levels. GCA administration in BDL group inhibited gastric acid output and volume. Our results suggest that oral or colonic administration of primary bile acids may be useful for the treatment of gastrointestinal inflammations.