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GÜLLÜOĞLU, MAHMUT BAHADIR

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GÜLLÜOĞLU

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MAHMUT BAHADIR

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1997 - 19994
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End date: 1999 × Start date: 1997 ×

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    Bombesin ameliorates colonic damage in experimental colitis
    (1999) YEGEN, BERRAK; Güllüoğlu, B. M.; Kurtel, H.; Güllüoğlu, M. G.; Aktan, A. O.; Yeğen, B. C.; Dizdaroğlu, F.; Yalin, R.; Yeğen, B. C.
    In the present study we investigated the possible therapeutic effects of bombesin on an experimentally induced colitis model in rats. Inflammation of the colon was induced by a single intracolonic administration of 30 mg of 2,4,6-trinitrobenzene sulfonic acid (TNBS) at 8 cm from the anus. Immediately after the induction of colitis, some rats were given bombesin (10 microg/kg; subcutaneously) three times a day for 14 days, while another group received vehicle treatment. On day 14, the rats were decapitated and plasma carbonyl content and tissue myeloperoxidase level, as an index of granulocyte infiltration into intestinal tissue, were determined in order to obtain an objective evaluation of colonic injury. In the colitis group, increased macroscopic damage score, elevated MPO level and high plasma carbonyl content, together with the microscopic appearance revealed severe inflammatory changes resembling IBD. Bombesin treatment attenuated the TNBS-induced colonic damage and stimulated histopathologically apparent mucosal proliferation, suggesting that bombesin may play a role in protecting gut integrity.
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    Incidence of Meckel's diverticulum in Turkey
    (John Wiley and Sons Ltd, 1997) BEKİROĞLU, GÜLNAZ NURAL; Aktan A.Ö., Güllüoǧlu B.M., Cingi A., Bekiroǧlu N.
    [No abstract available]
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    Role of endothelins in trinitrobenzene sulfonic acid-induced colitis in rats
    (KARGER, 1999) YEGEN, BERRAK; Gulluoglu, B; Kurtel, H; Gulluoglu, MG; Yegen, C; Aktan, AO; Dizdaroglu, F; Yalin, R; Yegen, BC
    To determine the role of endothelins (ET) on experimental colitis, following intracolonic trinitrobenzene sulfonic acid administration, rats were given orally either bosentan (BS), a nonselective ET receptor antagonist (100 mg/kg in 5% arabic gum), or arabic gum by gavage for 2 or 14 days. Macroscopic damage scores obtained in the vehicle (1.4 +/- 0.4), acute (4.8 +/- 0.6) and chronic (3.8 +/- 0.3) colitis groups were significantly higher than in the control group (0). BS treatment reduced the scores in both acute (3 +/- 0.5) and chronic (2.3 +/- 0.5) colitis groups. Myeloperoxidase (MPO) activities of colonic tissues were elevated in acute and chronic colitis groups (325.1 +/- 44.9 and 431.8 +/- 54.6 U/g wet weight) as compared with the control group (73.6 +/- 11 U/g wet weight). Plasma protein oxidation levels were found to be significantly increased in the chronic colitis group (1,158.1 +/- 63.4 nmol/ml) compared with the control, ethanol and acute colitis groups (274.3 +/- 23.1, 490 +/- 52.2 and 422.2 +/- 50.5 nmol/ml). BS treatment significantly reduced both the protein oxidation level (375.5 +/- 46.9 nmol/ml) and MPO activity (167.5 +/- 35.8 U/g wet weight). The results of the present study suggest the involvement of ETs in the pathogenesis of colonic injury in this animal model of colitis.
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    Prospective multicentre trials in developing countries: Willingness of surgeons to participate
    (Scandinavian University Press, 1998) GÜLLÜOĞLU, MAHMUT BAHADIR; Aktan A.Ö., Güllüǒglu B.M., Cingi A.
    Objective: To assess the feasibility of conducting a multicentre study among surgeons in Turkey. Design: Prospective open multicentre study. Setting: Teaching hospitals in Turkey. Subjects: Surgeons working in 23 university and 15 state hospitals. Interventions: Surgeons willing to participate were asked to look for the presence of Meckel's diverticulum in all patients undergoing laparotomy. Main outcome measures: To find out the number of surgeons willing to participate in the study and once they agreed to see how they fulfilled the requirements. Results: 14 agreed to participate (12 from universities and 2 from state hospitals) and completed the study. A total of 2781 patient records were collected. University hospitals were more willing to participate than state hospitals (52% compared with 13%) but state hospitals contributed 20% of the patients. The number of patients contributed in the first and second halves of the study did not differ, reflecting no diminution of the enthusiasm. Conclusion: This study, with no financial support, showed that it is possible to conduct multicentre studies among surgeons in developing countries such as Turkey. Increased awareness of the importance of publication may have helped to obtain this result.