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TÜRK, SEVDA

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Author: KAYMAKÇIOĞLU, BEDİA × Subject: sulfonamide ×

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    PublicationOpen Access
    Some N-(5-methyl-1,3,4-thiadiazol-2-yl)-4-[(3-substituted)ureido/thioureido]benzenesulfonamides as carbonic anhydrase I and II Inhibitors
    (MARMARA UNIV, FAC PHARMACY, 2016-08-25) KAYMAKÇIOĞLU, BEDİA; Turk, Sevda; Tok, Fatih; Celik, Hulya; Karakus, Sevgi; Nadaroglu, Hayrunnisa; Kocyigit-Kaymakcioglu, Bedia; Kucukoglu, Kaan
    In the present study, N-(5-methyl-1,3,4-thiadiazol-2-yl)-4-[(3-substituted)ureido]benzenesulfonamide (1-9) and N-(5-methyl-1,3,4-thiadiazol-2-yl)-4-[(3-substituted) thioureido]benzenesulfonamide (10-14) derivatives were synthesized from 4-amino-N-(5-methyl-1,3,4-thiadiazol-2-yl) benzenesulfonamide (sulfamethizole). All new compounds were characterized by elemental analysis and various spectroscopic methods (FTIR, H-1-NMR and MS). These new sulfonamide derivatives were investigated as inhibitors of carbonic anhydrase especially human carbonic anhydrase I and II. The new compounds showed higher activity against the human cytosolic CA I (IC50 values 0.144-15.65 nM) and CA II (IC50 values 0.109-17.95 nM) in comparison with the clinically used CA inhibitor acetazolamide.