Person: BECEREN, AYFER
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BECEREN
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AYFER
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Publication Open Access Safety of herbal drugs(2023-01-01) BECEREN, AYFER; BECEREN A.Publication Metadata only Evaluation of antioxidant, analgesic, anti-inflammatory and antispasmodic activity and genotoxic effect of micromeria fruticosa subsp brachycalyx in vitro and in vivo(2021-07-22) KABASAKAL, LEVENT; TAŞKIN, TURGUT; AYDEMİR, SEZGİN; BECEREN, AYFER; Çelikkol I., Beceren A., Kabasakal L., Taşkın T., Aydemir S.EVALUATION OF ANTIOXIDANT, ANALGESIC AND ANTIINFLAMMAUTORY ACTIVITY AND GENOTOXIC EFFECT OF MICROMERIA FRUTICOSA SUBSP BRACHYCALYX IN VITRO AND IN VIVO1Celikkol I., 2Beceren A., 3Kabasakal L., 4Taskin T., 5Aydemir S.1Marmara University, Institute of Health Sciences, Department of Pharmaceutical Toxicology Istanbul, Turkey, celikkolisik@gmail.com 2Marmara University, Department of Pharmaceutical Toxicology, Istanbul, Turkey, ayfertozan@hotmail.com 3Marmara University, Department of Pharmacology, Istanbul, Turkey, lkabasakal@gmail.com 4Marmara University, Department of Pharmacognosy, Istanbul, Turkey, turguttaskin@marmara.edu.tr 5Marmara University, Vocational School of Health Services, Department of Medical Services and Techniques, Istanbul, Turkey, szgnaydemir@gmail.comIntroduction: Today, antioxidants have been using diversely in various medical conditions. Therefore, there are growing interest for discovering and developing more effective and safer antioxidants derived from natural sources. Certain Micromeria species were identified as a rich source of antioxidant agents (1). This study aimed to investigate possible antioxidant activity and genotoxicity of Micromeria fruticosa subsp brachycalyx in methanol extract both in vitro and in vivo.Materials and Methods: In vitro antioxidant activity of Micromeria fruticosa subsp brachycalyx in methanol extract was evaluated by DPPH, ABTS, FRAP and CUPRAC assays. In vivo analyses performed on Balb/c mice that divided to three groups (n=6 for each group) as control group (%0,04 Carboxymethyl cellulose solution (CMC), 0,1 mL/10 g, p.o.), positive control group (Indomethacin in %0,04 CMC, 10 mg/kg, p.o.) and treatment group (Micromeria extract in %0,04 CMC, 200 mg/kg, p.o.) and each regimen was applied for 10 days. Myeloperoxidase levels were analyzed in mice liver and kidney tissues. Genotoxic effect was determined in mice blood with Comet Technique. The 8-hydroxy-2’-deoxyguanosine was analyzed in mice liver and kidney tissues with commercial ELISA kit. Results: The results showed that plant extract showed stronger DPPH radical scavenging activity, however, lower ABTS, CUPRAC and FRAP values versus to standards. According to the graph, which shows the elapsed time (second) in pain behavior versus time (minute) for each group, treatment group exhibited its efficacy in late phase (20-30 min) similar with indomethacin group. Myeloperoxidase levels in liver tissues of the extract group were significantly lower compared to the control group (p<0.05). Myeloperoxidase levels in kidney tissues of the extract group were not significantly different compared to both control and indomethacin group. Micromeria fruticosa subsp brachycalyx extract exerted no genotoxic effect on DNA similarly both control and indomethacin group.Conclusions: Our study showed that Micromeria fruticosa subsp brachycalyx has a potential antioxidant activity. It has also been contributed to raise awareness to this species in terms of its safety with the obtained results. Therefore, the usage of this species as natural antioxidant source is promising for new drug candidates.Acknowledgements:Not available.References: 1. Salameh N et al., (2020) Screening of Antioxidant and Antimicrobial Activity of Micromeria fruticosa serpyllifolia Volatile Oils: A Comparative Study of Plants Collected from Different Regions of West. BioMed Research International, 1-7.Publication Open Access Evaluation of clinical pharmacist interventions on drug-related problems in the gastroenterology ward(2022-01-01) SANCAR, MESUT; BECEREN, AYFER; CEYLAN C., SANCAR M., BECEREN A., Demir A., KUŞ C., Omurtag G. Z.Integrating clinical pharmacists in a multidisciplinary patient care team improves the treatment process by identifying and resolving drug-related problems (DRPs). The aim of the study was to determine the effect of clinical pharmacist intervention for DRPs in the gastroenterology service. The first period of the study was conducted between 15.06.2018 and 15.02.2019. Eighty patients admitted to the gastroenterology ward, who used at least one medication, were included in \"the study group\". The clinical pharmacist participated in ward rounds and made interventions to solve identified DRPs. In the second period of the study, the control group consisted of 80 patients admitted to the same ward between 01.03.2019 and 06.06.2019. DRPs were determined only from the data obtained from the hospital system in the control group. DRPs were classified according to the European Pharmaceutical Care Network (PCNE V9.1). A total of 136 and 46 with an average of 1.7 and 0.57 DRPs per patient (p <= 0.01) were identified in the study and control groups, respectively. Of the DRPs in the study group, 59 were related to treatment effectiveness, while 61 were related to treatment safety. Likewise, 21 DRPs were related to treatment effectiveness in the control group, while 12 were related to treatment (p <= 0.01). 65% of the interventions were made at the physician level and 49% at the drug level. 97% (n=133) of the total interventions were accepted. The number of DRPs was significantly reduced in the control group within the time frame after the clinical pharmacist intervention period. In conclusion, clinical pharmacists\" importance in detecting and preventing DRPs in the gastroenterology ward has been demonstrated.Publication Open Access Determination of in vitro genotoxic effects of pine resin and Aronia melonacarpa on prostate and breast cancer cell lines by using comet assay technique(2022-11-05) BECEREN, AYFER; BİNGÖL ÖZAKPINAR, ÖZLEM; Beceren A., Bingöl Özakpınar Ö.The cancer burden continues to grow globally and places extraordinary physical, emotional and financial pressures on individuals, communities and health systems. Studies continue without slowing down to establish new targets and treatment strategies for cancer, which still remains an important problem in the clinic and does not have a definitive cure yet. Natural compounds obtained from different sources stand out as new therapeutic agents in cancer due to their more effective and selective properties and lower toxic effects. Thus, we aimed to clarify the possible anticancer effects of Aronia melonacarpa on human breast cancer cell line (MCF-7) and pine resinon prostate cancer cell line (PC-3).Our target plants, pine resin and Aronia melonacarpa were collected from different locations from Aegean and Blacksea region of Türkiye, respectively. The genotoxic effect of the methanol extracts was determined by alkaline comet assay. 100, 200 and 400 μg/ml extract concentrations, which have the high cytotoxic effect, were used. The examined groups were control negative, plant extract and positive control groups. Comparison of the anti-cancer and genotoxic effect of different concentrations on MCF-7 of Aronia melonacarpa and pine resin on PC-3 was evaluated by SPSS 20.0 program. Comet assay results showed that the both Aronia melonacarpa and pine resin extract exhibited genotoxic effects against MCF-7 and PC-3 cell lines in a dose-dependent manner by increasing the mean percentage of DNA damage after 24hrs of treatment (p<0.001).However, the observed toxicity of this two plant extract needs to be confirmed by additional studies. Based on our results, further examination of the potential anticancer properties of two plant species and the identification of the active ingredients of these extracts is warranted. This preliminary study is important for future studies and we anticipate that it will contribute to the development of a new drug in cancer treatment.Publication Open Access Polyphenolic composition and Antioxidant Effect of Aerial Parts and Roots Extracts from Scorzonera veratrifolia(2021-08-17) DOĞAN, AHMET; Taşkin, Duygu; Geçi̇M, Mert; Doğan, Ahmet; Beceren, AyferPublication Metadata only It Is Time to Revitalize the Antibiotic Pipeline: Systems Ecology Can Help(MARY ANN LIEBERT, INC, 2020) BECEREN, AYFER; Sardas, Semra; Buyuk, Ayse Seyma; Beceren, AyferAntimicrobials have been known for millennia, but innovative antibiotics are currently in short supply. New antimicrobial discoveries are being threatened by planetary scale loss of biodiversity that has important impacts on species and ecosystems. This expert review underscores that microorganisms in nature and their diversity are essential cornerstones to revitalize the antibiotic innovation and discovery pipeline. The recent rise of systems ecology and planetary health offers new and actionable potentials in this regard. Without a systems scale focus and appreciation of systems ecology, the global threats to human and planetary health from inappropriate use of antibiotics and antimicrobial resistance will continue to escalate with serious consequences to all life on the planet. With acutely pressing research and development needs to revitalize antibiotic treatment and novel diagnostic tools for personalized medicine, national health systems ought to work across knowledge silos not only within but also across the ministries, for example, health, agriculture, environment, economy, trade, and social services ministries that collectively impact on systems ecology and by extension on health innovations including the antibiotic discovery pipeline. Such systems vision can also help to revitalize antibiotic discovery pipeline as most antibiotics have natural origins or have designs inspired or based on molecules in the environment and microorganisms that produce antibiotics. Above all, our audience and responsibility include every person who has an interest in his or her own health, in the health of his or her fellow human beings and all life on the planet, and in the health of future generations.