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UĞURLU, MUSTAFA ÜMİT

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UĞURLU

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MUSTAFA ÜMİT

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2016 - 201932020 - 20232
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Author: GÜLLÜOĞLU, MAHMUT BAHADIR × Has files: true ×

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    PublicationOpen Access
    Regional Clinical and Biochemical Differences among Patients with Primary Hyperparathyroidism
    (GALENOS YAYINCILIK, 2017-01-15) GÜLLÜOĞLU, MAHMUT BAHADIR; Makay, Ozer; Ozcinar, Beyza; Simsek, Turgay; Arici, Cumhur; Gungor, Bulent; Ozbas, Serdar; Akca, Tamer; Emre, Ali Ugur; Cakmak, Guldeniz Karadeniz; Akcay, Mufide; Unal, Bulent; Girgin, Mustafa; Girgin, Sadullah; Gorgulu, Semih; Sezer, Atakan; Karatas, Adem; Ozemir, Ibrahim Ali; Aksakal, Nihat; Erel, Serap; Ugurlu, M. Umit; Filiz, Ali Ilker; Atalay, Can; Uzunkoy, Ali; Deveci, Ugur; Kotan, Cetin; Icoz, Gokhan; Kurt, Yavuz; Kebudi, Abut; Canturk, N. Zafer; Erbil, Yesim; Pandev, Rumen; Gulluoglu, Bahadir M.
    Background: Environmental habitat may play a role in clinical disparities of primary hyperparathyroidism (pHPT) patients. Aims: To compare preoperative clinical symptoms and associated conditions and surgical findings in patients with pHPT, living in different geographical regions from the Black Sea, Mediterranean and Anatolia regions. Study Design: Retrospective, clinical-based multicentric study of 694 patients with pHPT. Methods: Patients from 23 centers and 8 different geographical regions were included. Data related to baseline demographics, clinical, pathologic and treatment characteristics of 8 regions were collected and included age, gender, residential data, symptoms, history of fracture, existence of brown tumor, serum total Ca and p levels, serum parathormone (PTH) levels, serum 25-OH vitamin D levels, bone mineral density, size of the resected abnormal parathyroid gland(s), histology, as well as the presence of ectopia, presence of dual adenoma, and multiple endocrine neoplasia (MEN)- or familial-related disease. Results: The median age was 54. Asymptomatic patient rate was 25%. The median PTH level was 232 pg/mL and serum total Ca was 11.4 mg/dL. Eighty-seven percent of patients had an adenoma and 90% of these had a single adenoma. Hyperplasia was detected in 79 patients and cancer in 9 patients. The median adenoma size was 16 mm. Significant parameters differing between regions were preoperative symptoms, serum Ca and p levels, and adenoma size. All patients from South-East Anatolia were symptomatic, while the lowest p values were reported from East Anatolia and the largest adenoma size, as well as highest Ca levels, were from Bulgaria. Conclusion: Habitat conditions vary between geographical regions. This affects the clinicopathological features of patients with pHPT.
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    PublicationOpen Access
    Minimally invasive thyroid anaplastic carcinoma with long survival
    (TURKISH SURGICAL ASSOC, 2018-01-15) ERBARUT SEVEN, İPEK; Ugurlu, Mustafa Umit; Seven, Ipek Erbarut; Eren, Funda; Yegen, Cumhur; Gulluoglu, Bahadir Mahmut
    Anaplastic thyroid carcinoma is a highly lethal malignancy. Previously, only five cases of a noninvasive form of anaplastic thyroid carcinoma with excellent prognosis were reported, We report a case of a 68-year-old man who presented with a 3,8 cm thyroid nodule diagnosed by fine needle aspiration biopsy as poorly differentiated spindled and epithelial malignant cells, Lobectomy and isthmusectomy were performed, and the final diagnosis was micro-invasive anaplastic thyroid carcinoma arising in a poorly differentiated carcinoma, The patient remains disease-free after six years, even after hemithyroidectomy and radiation treatment. Noninvasive/micromvasive anaplastic thyroid carcinoma appears to be a different disease entity from classical anaplastic thyroid carcinoma, with favorable prognosis and long disease-free survival.
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    PublicationOpen Access
    Association of biochemical and clinical parameters with parathyroid adenoma weight. Turkish-Bulgarian endocrine and breast surgery study group, hyperparathyroidism registry study
    (2022-01) GÜLLÜOĞLU, MAHMUT BAHADIR; Özçınar, Beyza; Öner, Gizem; Makay, Özer; Soyder, Aykut; Zafer Cantürk, N.; Ümit Uğurlu, M.; Atakan Sezer, Y.; Görgülü, Semih; Girgin, Mustafa; Özemir, A. İbrahim; Özbaş, Serdar; Ünal, Bülent; Pandev, Rumen; Erel, Serap; Uğur Emre, A.; İlker Filiz, A.; Nuran Akçay, M.; Demircioğlu, Salih; Güler, S. Ata; Öztürk, Erkan; Yıldız, Ramazan; Çakmak, Güldeniz Karadeniz; Kurt, Yavuz; Erbil, Yeşim; Güllüoğlu, Bahadır M.
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    PublicationOpen Access
    Prediction of nipple involvement in breast cancer after neoadjuvant chemotherapy: Should we rely on breast MRI to preserve the nipple
    (2023-01-01) UĞURLU, MUSTAFA ÜMİT; BUĞDAYCI, ONUR; AKMERCAN, AHMET; KAYA, HANDAN; AKOĞLU, HALDUN; GÜLLÜOĞLU, MAHMUT BAHADIR; UĞURLU M. Ü., BUĞDAYCI O., AKMERCAN A., KAYA H., AKIN TELLİ T., AKOĞLU H., GÜLLÜOĞLU M. B.
    Background: Indications for nipple sparing mastectomy (NSM) is extending to post-neoadjuvant chemotherapy (NAC) setting. Eligibility for NSM with an optimum tumor-nipple distance (TND) after NAC is unclear. We examined predictive factors for nipple tumor involvement in patients undergoing total mastectomy following NAC. Methods: Clinical and pathological data from prospectively collected medical records of women with invasive breast carcinoma, who were undergone NAC and total mastectomy with sentinel lymph node biopsy and/or axillary lymph node dissection were analyzed. PreNAC and postNAC magnetic resonance imaging (MRI) views were examined and a cut-off TND value for predicting the negative nipple tumor status was determined. Results: Among 180 women, the final mastectomy specimen analysis revealed that 12 (7%) had nipple involvement as invasive carcinoma. Patients with nipple involvement had more postNAC multifocal/multicentric tumors (p: 0.03), larger tumors on preNAC and postNAC images (p: 0.002 and p 2mm) on preNAC and postNAC images (p < 0.001 and p: 0.01). The best likelihood ratios (LR) belonged to the postNAC positivity of the < 20 mm TND, with a + LR of 3.40, and − LR of 0.11 for nipple involvement. PreNAC positivity of the < 20 mm TND also had a similar − LR of 0.14. Conclusion: A TND-cut-off ≥ 2 cm on preNAC and postNAC MRI was shown to be highly predictive of negative nipple tumor involvement.
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    PublicationOpen Access
    2-(fluorine-18)-fluoro-2-deoxy-D-glucose positron emission tomography/computed tomography after breast conserving surgery: Correlation with molecular markers of breast cancer
    (MEDKNOW PUBLICATIONS & MEDIA PVT LTD, 2016) TUROĞLU, HALİL TURGUT; Ozguven, Salih; Inanir, Sabahat; Turoglu, Halil Turgut; Erdil, Tanju Yusuf; Ugurlu, Mustafa Umit; Gulluoglu, Bahadir
    Aim: To investigate the role of 2-(fluorine-18)-fluoro-2-deoxy-D-glucose (F-18-FDG) positron emission tomography/computed tomography (PET/CT) early after breast-conserving surgery (BCS) in patients with breast cancer (BC) and whether we can determine which molecular biomarkers of breast carcinoma put the patients at risk. Materials and Methods: This retrospective study involved 88 patients with histologically proven T1 or T2 BC, who were treated with BCS and underwent F-18-FDG PET/CT study. The correlation between biological markers (estrogen receptor, progesterone receptor, human epidermal growth factor receptor 2 [HER2], and Ki-67) of the primary tumor and F-18-FDG PET/CT findings was analyzed. Results: F-18-FDG PET/CT demonstrated the presence of BC disease (locoregional disease [LRD], distant metastases, or contralateral BC) in 26 of 88 patients (29.5%). Regarding immunohistochemical profiles, BC expressing high levels of Ki-67 were associated with an increased percentage of LRD, which was the major recurrence pattern on F-18-FDG PET/CT. Although the BC disease was observed more commonly in patients with HER2 positivity compared to those of HER2 negative, the difference did not reach statistical significance. The patients with T2 tumor or a higher histopathological grade had a higher percentage of BC disease. Conclusions: This study demonstrated that patients with early stage BC treated with BCS have a remarkable risk of the presence of BC even early after surgery, and there was a clinically important relationship between F-18-FDG PET/CT findings and biological markers of BC. These findings suggest that high-risk molecular biomarkers (Ki-67, HER2) can be taken into account in the decision-making the process for both preoperative imaging and planning of the surgical approach.