Person: UĞURLU, MUSTAFA ÜMİT
Loading...
Email Address
Birth Date
Research Projects
Organizational Units
Job Title
Last Name
UĞURLU
First Name
MUSTAFA ÜMİT
Name
13 results
Search Results
Now showing 1 - 10 of 13
Publication Metadata only Metastazı taklit eden brown tümörler: Paratiroid sintigrafisi ve PET/BT bulguları(2022-05-01) KESİM, SELİN; TUROĞLU, HALİL TURGUT; UĞURLU, MUSTAFA ÜMİT; ÖZGÜVEN, SALİH; ENGÜR, CEREN ÖZGE; FİLİZOĞLU, NUH; ÖNEŞ, TUNÇ; ERDİL, TANJU YUSUF; BALABAN GENÇ, ZEYNEP CEREN; Kesim S., Turoğlu H. T., Uğurlu M. Ü., Özgüven S., Engür C. Ö., Filizoğlu N., Niftaliyeva K., Kıssa T. N., Balaban Genç Z. C., Öksüzoğlu K., et al.Amaç: Kronik böbrek yetmezliğinde sürekli ve aşırı üriner kalsiyum atılımı, serum kalsiyum seviyelerini düşürerek parathormon düzeyinde artışa neden olur. Serum kalsiyum seviyelerini normal sınırlar içinde tutmak için kompansatuvar olarak oluşan hızlı osteoklastik kemik döngüsü brown tümörlerin oluşmasına neden olabilir. Bu olgu sunumunda, sekonder hiperparatiroidiye ikincil multipl brown tümörleri olan olgunun dual faz Tc-99m metoksiizobutilizonitril (MIBI) paratiroid sintigrafisi ve florodeoksiglukoz (F-18 FDG) pozitron emisyon tomografisi/bilgisayarlı tomografide (PET/BT) bulguları sunulmaktadır. Yöntem: Son dönem böbrek yetmezliği ile takip edilen, diyaliz bağımlı, serum fosfat, alkalen fosfataz ve paratiroid hormon seviyesi yüksek iken, serum kalsiyum seviyesi düşük olan, 57 yaşındaki kadın hastaya sekonder hiperparatiroidi etiyolojisi araştırılması amacıyla dual faz Tc99m MIBI paratiroid sintigrafisi yapıldı. Paratiroid sintigrafisi ile toraks BT görüntülemesinde kemik metastazlarını taklit eden osteolitik lezyonlarraporlanan olguya primer malignite araştırılması amacıyla F-18 FDG PET/BT görüntülemesi yapıldı. Bulgular: Tc-99m MIBI paratiroid sintigrafisinde erken ve geç fazda sağ ve sol alt paratiroid lojunda izlenen nodüler lezyonlarda multiglandüler paratiroid patolojisi ile uyumlu olarak değerlendirilen artmış aktivite tutulumu izlendi. Ek olarak, SPECT/CT (Tek foton emisyon bilgisayarlı tomografi) görüntülerinde sağ 4. ve 7. kosta anterolateralinde artmış MIBI tutulumu gösteren ekspansil osteolitik lezyonlar dikkati çekti (Şekil 1). Tanımlanan ekspansil lezyonların metastaz olma olasılığı açısından F-18 FDG PET/BT tetkikine refere edilen olguda; PET/BT görüntülemesinde aksiyel ve apendiküler iskelette yaygın yoğun hipermetabolik litik/yer yer ekspansil karakterde multipl lezyonlar izlendi. Ayrıca tiroid glandı her iki lob alt pol komşuluğunda yoğun hipermetabolik heterojen dansiteli nodüler lezyonlar saptandı (Şekil 2). Paratiroidektomi operasyonu yapılan hastada biyopsi sonucu paratiroid hiperplazisi ile uyumlu olarak raporlandı. Sonuç: Brown tümörler, neoplastik olmayan, hipervasküler kemik tümörleri olup hiperparatiroidizmin ciddi bir komplikasyonudur. Bu osteolitik lezyonların ayırıcı tanısısında dev hücreli onarım granülomu, metastaz, multipl myelom-plasmositom ve görüntüleme yöntemleriyle veya histolojik olarak ayırt edilemeyen dev hücreli kemik tümörü bulunur. Bununla birlikte, hastanın biyokimyasal profili tanı koymaya yardımcı olabilir. Brown tümörlerin kemik sintigrafisinde ve MIBI sintigrafisinde saptanabileceği gösterilmiştir. Ayrıca PET/BT tetkikinde osteoklast-benzeri dev hücreler ile makrafojlardaki artmış glukoz metabolizması sebebiyle FDG tutulumu gösterebilmektedir. Ayrıca, brown tümörlerin hiperparatiroidizm tedavisini takiben FDG afinitelerini kaybettiği bildirilmiştir. Kronik böbrek hastalığı ve hiperparatiroidi anamnezi olan olgularda; metastaz şüpheli osteolitik lezyonlar değerlendirilirken ayırıcı tanıda Brown tümörler göz önünde bulundurulmalıdır. Anahtar Kelimeler: Hiperparatiroidi, brown tümör, Tc-99m MIBI paratiroid sintigrafisi, SPECT/BT, F-18 FDG PET/BTPublication Open Access Effect of the pandemic on surgical procedures in a tertiary care hospital: A retrospective review(2022-09-01) SAÇAK, BÜLENT; KESİMER, MEHMET DENİZ; ŞAHİN, BAHADIR; UĞURLU, MUSTAFA ÜMİT; SAKAR, MUSTAFA; YUMUŞAKHUYLU, ALİ CEMAL; Ozkan M. C. , SAÇAK B., KESİMER M. D. , ŞAHİN B., UĞURLU M. Ü. , Sirzai E. Y. , SAKAR M., Aykut A., Cicek I., YUMUŞAKHUYLU A. C.Objective: The aim of this study was to examine the impact of performing surgeries with necessary precautions and to evaluate demographic characteristics of operated patients during novel coronavirus-2019 (COVID-19) pandemic and the infection rates during hospitalization and within 14 days after surgery.Publication Open Access Changes in 18F-FDG-PET/CT tumor metabolism are not consistent with pathologic complete response in hormone-positive breast cancer(2017-09-01) DEDE, FUAT; KAYA, HANDAN; UĞURLU, MUSTAFA ÜMİT; Kaya S., Aktas B., Tanrikulu E., ÖZTÜRK M. S., DEDE F., KAYA H., Ugurlu U., Ozgen Z., Koca S., Halil S., et al.© 2017 Zerbinis Publications. All rights reserved.Purpose: Current evaluation of response to neoadjuvant chemotherapy (NAC) shows that it could achieve pathological complete response (pCR). The purpose of this study was to assess the consistency of maximum uptake values (SUVmax) changes and pCR in hormone-positive locally advanced breast cancer (LABC). Methods: Ninety hormone-positive LABC patients treated at Marmara University Medical Oncology Clinic, Istanbul, Turkey, between 2009 and 2015 were retrospectively studied. All eligible patients (n=51) received NAC (4-8 cycles) and were evaluated for pCR. 18F-fluorodeoxyglucose positron emission tomography/ computed tomography (18F-FDG-PET/CT) scan was performed before and after the completion of NAC. The relative changes of SUVmax both in the primary tumor and the axilla were assessed for consistency with pCR. Results: The patient median age was 46 years (range 26-76). The patients 13.7% achieved pCR. Values of >50% (n=40) and 75% SUVmax changes could achieve pCR of 20%. Interestingly, most patients with complete metabolic response did not achieve pCR (81%). The difference of the Ki67 levels before and after NAC, tumor localization, HER-2 positivity, menopausal status, grade of differentiation, lymphovascular and perineural invasion were not associated with pCR. Conclusion: SUVmax changes in later cycles of NAC as commonly practised in oncology clinics were not consistent with pCR (p=1.0). Complete metabolic response may not be associated with pCR in hormone-positive LABC. However, almost 80% of patients had >50% decrease in SUVmax and may still have a chance for conservative surgery and less postoperative morbidity. Therefore, 18F-FDG-PET/CT may still have a role to evaluate the tumor response with a need of larger studies and analysis for cost-effectiveness.Publication Metadata only Sentinel lymph node biopsy with/without axillary dissection in clinically node-positive breast cancer after neoadjuvant chemotherapy(2022-04-01) UĞURLU, MUSTAFA ÜMİT; Cabioglu N., Karanlik H., Gulcelik M. A., Ilgun S., Igci A., URAS C., Cakmak G. K., UĞURLU M. Ü., Muslumanoglu M., KOÇER H. B., et al.Publication Metadata only Neoadjuvan kemoterapi̇ veri̇len lokal İleri̇ evre meme kanserli̇ hastaların genel karekteri̇sti̇k özelli̇kleri̇ni̇n İncelenmesi̇(2015-04-21) UĞURLU, MUSTAFA ÜMİT; ÖZGEN, ZERRİN; DANE, FAYSAL; Kaya S., Tanrıkulu Şimşek E., Uğurlu M. Ü., Özgen Z., Köse H., Halil S., Beşiroğlu M., Koca S., Babacan N., Dane F., et al.Publication Metadata only Conventional tools for predicting satisfactory response to neoadjuvant chemotherapy in HR+/HER2- breast cancer patients(2023-10-01) GÜLLÜOĞLU, MAHMUT BAHADIR; EREN, ÖZGÜR CAN; KAYA, HANDAN; UĞURLU, MUSTAFA ÜMİT; Oprea A. L., GÜLLÜOĞLU M. B., Aytin Y. E., EREN Ö. C., Aral C., Szekely T. B., TAŞTEKİN E., KAYA H., BADEMLER S., Karanllk H., et al.Aim: The aim of the study was to assess the role of Magee Equation 3 (MagEq3), IHC4 score, and HER2-low status in predicting \"satisfactory response (SR)\"to neoadjuvant chemotherapy (NAC) in HR+/HER2- breast cancer (BC) patients. Methods: In a retrospective study, female patients of any age with T1-4, N0-2, M0 HR+/HER2- BC who received NAC and underwent adequate locoregional surgical treatment were included. Patients were grouped according to 2 outcomes: (a) overall response to NAC in breast and axilla by using residual cancer burden (RCB) criteria and (b) axillary downstaging after NAC by using N staging. 2 cohorts for overall response were overall SR (RCB 0-1) and no SR (RCB 2-3). On the other hand, for axillary downstaging, 2 cohorts constituted from axillary SR (ypN0 and ypN0i+) and no SR (ypNmic-N3). MagEq3 and IHC4 scores were calculated from their pathological tumor slides in each patient. HER2 status was categorized as either \"no\"or \"low.\"In addition, patient age, family history, tumor histology, stage at admission, and Ki-67 status were compared between cohorts according to predefined outcomes. Results: In a total of 230 BC patients, 228 patients were included to compare according to their RCB levels. The mean age of patients with overall SR was significantly lower than those without. Patients with high Ki-67 expression, high (>30) MagEq3 score, high ICH4 quartile, and HER2-low status had significantly more overall SR. On the other hand, only patients with high Ki-67 expression had significantly more axillary SR. MagEq3 score levels, ICH4 quartiles, and HER2 status were similar between patients with axillary SR and not. Conclusion: MagEq3 and IHC4 tools seemed to be useful to predict those HR+/HER2- BC patients who are most likely to get benefit from NAC. But, only high Ki-67 expression level significantly predicted satisfactory axillary downstaging in HR+/HER2- BC patients.Publication Open Access Predictive value of (18)F-FDG PET/CT indices on extensive residual cancer burden in breast cancer patients treated with neoadjuvant chemotherapy.(2022-05-01) UĞURLU, MUSTAFA ÜMİT; KÖSTEK, OSMAN; ÖZGÜVEN, SALİH; Başoğlu T., Özgüven S., Özkan H. Ş., Çınar M., Köstek O., Demircan N. C., Arıkan R., Telli T. A., Ercelep Ö., Kaya H., et al.Aim: We investigated the correlation between 18F-FDG PET/CT indices and pathological response in breast cancer treated with neoadjuvant chemotherapy (NACT) which was scored with Residual Cancer Burden (RCB) system after surgery. Our aim is to detect extensive residual cancer burden earlier by using PET/CT indices. Methods: Characteristics of patients were retrieved retrospectively. Baseline maximum Standart Uptake Value (SUVmax), Metabolic Tumor Volume (MTV) and Total Lesion Glycolysis (TLG)indices and reduction rate (RR) between baseline and interim evaluation were calculated with FDG PET/CT scan. All patients were evaluated according to RCB scores after surgery. Pathological responses and PET/CT measurement results were analyzed with demographic and clinical parameters. Results: A total of 95 patients were included in the study. According to pathological responses, the distribution of RCB -0, -1, -2, -3 were 13 (13.7%), 11 (11.6%), 30 (31.6%), 41 (43.2%), respectively. Diseasefree survival was significantly lower in the RCB3 group compared to the pathological responder group (p = 0.01). According to multivariate analysis, RR of SUVmax was determined as an independent variable predicting extensive residual cancer burden with an optimal cut-off value of 86% (p < 0.05). Conclusions: We determined RR of SUVmax as an independent factor for predicting extensive residual tumor burden. We believe that RR of SUVmax is sufficient to predict pathological response in daily practice. In addition, MTV and TLG measurements do not contribute additionally to SUVmax alone and can cause unnecessary labor loss.Publication Metadata only Treatment outcomes of breast cancer patients older than 65 years old received local radiotherapy(2014-09-30) ATASOY, BESTE MELEK; ÖZGEN, ZERRİN; YUMUK, PERRAN FULDEN; UĞURLU, MUSTAFA ÜMİT; KAYA, HANDAN; GÜLLÜOĞLU, MAHMUT BAHADIR; Atasoy B. M., Kefeli A., Özgen Z., Rzayev R., Yumuk P. F., Uğurlu M. Ü., Kaya H., Arıbal M. E., Güllüoğlu M. B.Publication Open Access Prediction of nipple involvement in breast cancer after neoadjuvant chemotherapy: Should we rely on breast MRI to preserve the nipple(2023-01-01) UĞURLU, MUSTAFA ÜMİT; BUĞDAYCI, ONUR; AKMERCAN, AHMET; KAYA, HANDAN; AKOĞLU, HALDUN; GÜLLÜOĞLU, MAHMUT BAHADIR; UĞURLU M. Ü., BUĞDAYCI O., AKMERCAN A., KAYA H., AKIN TELLİ T., AKOĞLU H., GÜLLÜOĞLU M. B.Background: Indications for nipple sparing mastectomy (NSM) is extending to post-neoadjuvant chemotherapy (NAC) setting. Eligibility for NSM with an optimum tumor-nipple distance (TND) after NAC is unclear. We examined predictive factors for nipple tumor involvement in patients undergoing total mastectomy following NAC. Methods: Clinical and pathological data from prospectively collected medical records of women with invasive breast carcinoma, who were undergone NAC and total mastectomy with sentinel lymph node biopsy and/or axillary lymph node dissection were analyzed. PreNAC and postNAC magnetic resonance imaging (MRI) views were examined and a cut-off TND value for predicting the negative nipple tumor status was determined. Results: Among 180 women, the final mastectomy specimen analysis revealed that 12 (7%) had nipple involvement as invasive carcinoma. Patients with nipple involvement had more postNAC multifocal/multicentric tumors (p: 0.03), larger tumors on preNAC and postNAC images (p: 0.002 and p 2mm) on preNAC and postNAC images (p < 0.001 and p: 0.01). The best likelihood ratios (LR) belonged to the postNAC positivity of the < 20 mm TND, with a + LR of 3.40, and − LR of 0.11 for nipple involvement. PreNAC positivity of the < 20 mm TND also had a similar − LR of 0.14. Conclusion: A TND-cut-off ≥ 2 cm on preNAC and postNAC MRI was shown to be highly predictive of negative nipple tumor involvement.Publication Metadata only Primer hiperparatiroidizmde cerrahi öncesi ve sonrası kemik metabolizması parametreleri ile ilişkili faktörler Seçkin Akçay, Must(2022-05-20) AKÇAY, SEÇKİN; UĞURLU, MUSTAFA ÜMİT; YAVUZ, DİLEK; Akçay S., Uğurlu M. Ü. , Yavuz D.