Person: ULAĞ, SONGÜL
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ULAĞ
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SONGÜL
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Publication Metadata only Characterizations of ethosuximide-loaded bismuth ferrite nanoparticles for the potential treatment of epilepsy(2023-07-15) ULAĞ, SONGÜL; Ulağ S.Epilepsy is the most common neurological disease that affected people of all ages, races, social classes, and geographical locations. According to the 2019 World Health Organization (WHO) data, about 0.7 % of the population is struggling with epilepsy. In addition, nearly 5 million people are diagnosed every year. The basic characteristic of epilepsy is aberrant electrical activity in several brain regions. About %70 patients with epilepsy can be treated successfully with antiepileptic drugs to control the patient's seizures. 20–30% of patients exhibit pharmacoresistance, and only a small portion of these patients will benefit from surgical intervention. Therefore, developing a successful treatment for the disease is still quite difficult. To accomplish this objective, antiepileptic drug-loaded carrier nanoparticles can be an alternative treatment for epilepsy.Recent developments to improve the release of drugs from smart materials include Near Infrared Light (NIR) radiation (NIR), ultraviolet (UV) and visible wavelength light, magnetic fields, ultrasound, and electrical stimulation. Compared to drug delivery systems based on stable passive delivery, these strategies offer more effective control over the delivery of drugs. Nanoparticle drug carriers are being studied further for controlled drug delivery due to their benefits including good structure and tunable characteristics. Multiferroic materials due to their controllable possession, have drawn interest in recent years to develop new materials or structures. Bismuth ferrite (BiFeO3, BFO) is a single-phase multiferroic material with a polar R3c space group and rhombohedral distorted cell, has the ability to be both ferroelectric and antiferromagnetic.In this study, bare and drug loaded bismuth ferrite nanoparticles were synthesized by coprecipitation method. Bare and drug loaded nanoparticles were characterized by fourier transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), X-ray diffraction analysis (XRD), and scanning electron microscopy (SEM). Ethosuximide is an FDA-approved, made available as an efficient and generally well-tolerated medication to treat absence seizures. It prevents clonic seizures generated on by bicuculline or pentylenetetrazole when administered subcutaneously. Also, biological test was done by using microglia cells.Publication Metadata only Characterization of scaffolds for neural tissue engineering(Elsevier Science, Oxford/Amsterdam , 2023-05-01) ULAĞ, SONGÜL; Ulağ S.Publication Metadata only Fabrication, characterization and investigation of antibacterial activity of propolis substituted sodium alginate tissue scaffolds using three-dimensional (3d) printing technology(2021-06-05) UZUN, MUHAMMET; SU TORUN, SENA; ULAĞ, SONGÜL; AKSU, MEHMET BURAK; GÜNDÜZ, OĞUZHAN; CESUR, SÜMEYYE; Aarancı K., Uzun M., Su Torun S., Cesur S., Ulağ S., Amin A., Güncü M. M., Aksu M. B., Kolaylı S., Silva J., et al.Publication Metadata only Ethosuximide-loaded alginate/polyethylene oxide 3d-printed scaffolds for epilepsy treatment(2023-01-17) ULAĞ, SONGÜL; Ulağ S.A chronic medical disease known as epilepsy typically causes spontaneous, unprovoked repeated seizures that have an impact on a variety of mental and physical activities. The majority of epilepsy patients can manage their seizures with medical treatment. More than one-third of patients who do not receive adequate benefit from oral antiepileptic drug therapy continue to have seizures. It is considered as a proper option to design local drug release to the focal area of the brain where the seizure occurs in order to reduce side effects of antiepileptic drugs and to increase therapeutic efficacy by providing higher and more effective doses to the seizure focus. This study concentrates on polymer-based implants, which are polymeric devices loaded with AED and designed for implantation at the seizure focus to provide gradual, prolonged release of AED directly into the area of the brain responsible for seizures. Ethosuximide, an antiepileptic drug used in the treatment of absence seizures, was chosen as the active ingredient in this study. With 3D printing, implantable scaffolds consisting of Alginate and polyethylene oxide polymers and containing the active substance ethosuximide were produced. The properties of drug-containing polymeric scaffolds were investigated by SEM analysis, and their chemical and thermal properties were analyzed using DSC and FTIR, respectively. The drug release of the scaffolds was tested in vitro. In this study, human neuroblastoma cell line, SH-SY5Y (CRL-2266™, ATCC) was used for toxicity analysis.Publication Metadata only Development of microparticles containing polylactic acid/bioactive glass/caffeic acid(2023-07-15) ULAĞ, SONGÜL; Ulağ S.Bone diseases or defects cause significant problems for people around the world, both in terms of the economy and their health. The deficiencies in traditional methods have led researchers to focus on bone tissue engineering (BTE) and explore new and improved methods. In this study, the production and characterization of microparticles (MPs) for BTE are emphasized. By using the polylactic acid (PLA), bioactive glass (BG), and caffeic acid (CA) electrospray (ES) method with optimum parameters, four different types of MPs (3% PLA, 3% PLA/0.1% BGs, 3% PLA/0.1% CA, and 3% PLA/0.1% BGs/0.1% CA) were produced. Scanning electron microscopy (SEM) analysis revealed an increase in the mean diameter with the addition of substances. Fourier transform infrared spectroscopy (FTIR) analysis confirmed the presence of the main material, PLA. Differential scanning calorimetry (DSC) analysis demonstrated that the added substances affected the thermal properties of PLA. X-ray diffraction (XRD) analysis showed that the substances had minimal impact on the PLA pattern. In addition, in the in vitro drug release test, the release characteristics of CA from MPs were examined, and as a result, different compositions at different rates (180 min and 720 min) were determined. Moreover, the 3-(4,5- dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay results showed that the MPs did not show toxicity against human fetal osteoblastic (hFOB) 1.19 cell lines. In conclusion, this study provides comprehensive information about the production and characterization of MPs and will be a promising study for use in BTE studies thanks to the results obtained.Publication Metadata only Quantum Dot-Based Nanomaterials for Diagnostic and Therapeutic Applications.(Springer Nature, 2022-10-01) ULAĞ, SONGÜL; Ulağ S.Publication Metadata only Production of essential oil coated polycapralactone scaffold with antibacterial properties(2023-07-15) ULAĞ, SONGÜL; Ulağ S.Wound dressings are designed in a structure that can provide suitable environmental conditions for the healing of the wound that has occurred on any part of the skin. It can form an artificial tissue scaffold for cells and provides hygienic conditions for cells1 . Wound dressing is used in the treatment of wounds formed after various injuries and surgical interventions. The dressing protects the wound, reducing the risk of infection and accelerating the healing process. The dressings fit snugly to the wound area, closing the wound, reducing the risk of infection, and supporting the healing of injured tissues, helping the formation of new cells. It is used in the treatment of various wounds such as wound dressing, burns, cuts, scratches, surgical wounds2 . Extrusion bioprinting is based on the principle of extruding or dispersing material to build a 3D structure layer by layer. Typical extrusion bioprinting systems use pneumatic, screw-based or pistonbased mechanisms. Pneumatic systems are preferred because of their simplicity, but printing characteristics are largely dependent on the viscosity of the material.3 Mechanical systems are attractive because of the precise control of material flow; however, these systems generate high pressure and can damage the cells contained in the bioink. Fine details of the dressing can be produced with 3D extrusion printers. This technology is a method that can be used to create precise and customized dressings. In this proposed study, the wound dressing will be produced using an extrusion 3D printer (Hyrel 3D). In the next step, the produced wound dressings will be covered with polylactic acid (PLA) microparticles loaded with photosensitive, electrical properties and photodynamic activity of cardamom oil and St. John's wort oil nanoparticle using the electro-hydrodynamic atomization method (EDHA), which allows to produce micron-sized particles. Characterization tests of this sensitized wound dressing will be performed. Electron microscope (SEM) will be used to view the morphology of the wound dressing, Fourier transform infrared (FTIR) spectrometer device to learn about its molecular structure, differential scanning calorimetry (DSC) device to detect its thermal properties, tensile device to detect tensile strength, swelling and degradation tests. It will be tested on S.aureus and P.acruginosa bacteria to determine its antimicrobial property. In vitro cytotoxicity will be tested by performing a cell culture study. As a result, the proposed study aims to use an antimicrobial wound dressing with a surface coated with microparticles.Publication Metadata only Vitamin E microparticles coated on 3D polylactic acid (PLA)/polymethylsilsesquioxane (PMSQ) scaffold for wound healing applications(2023-07-15) ULAĞ, SONGÜL; Ulağ S.Skin is an important part of integumentary system and the excretory system, which can be injured and healed by the own body cells by having complex biological processes which generally needs 4 to 6 weeks according to injury type which differ according to etiology into surgical, penetrating, blunt, burn wounds, although,the depth of wound, severity, skin integrity and the degree of contamination plays a role in duration of wound healing. On the other hand other factors effect, some of this factors are local facors like oxygenation, infection, foreign body, venous and sufficiency, some of them are systemic factors like Age, gender, sex hormones, stress, ischemia, diseases (diabetes, uremia, obesity), medications (anti-inflammatory drugs, chemotherapy), Alcoholism, smoking, and Nutrition. For faster healing processes, 3D printed scaffolds were fabricated and coated with microparticles on its surface. In this study, PLA/PMSQ 3D printed scaffolds were fabricated and coated with vitamin E microparticles. Ethyl cellulose (EC) was mixed with vitamin E and used to load the vitamin E on the scaffolds by using electrospray device. PLA was used due to its desired properties of being biocompatible and providing controlled release of functional drugs and supplements. PMSQ was mixed with it due to its high hydrophobicity and prevents agglomeration and maintains free-flowing characteristics in loose-powder products. EC was used as barrier to deliver vitamin E microparticles and assist releasing of vitamin E process on the skin due to its hydrophobicity, lipophilicity and non-toxicity properties. Vitamin E was used because of its occlusive effect that provides penetration of the vitamin on the skin, and its chemical stability. The mechanical, thermal, chemical properties and morphological analysis of the vitamin E coated PLA/PMSQ scaffolds were examined. The drug release behaviour was tested in vitro and the biocompatibility test was done using MTT assay with fibroblast cell line.