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YALÇIN, AHMET SUHA

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YALÇIN

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AHMET SUHA

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1992 - 19973
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Subject: Lipid Peroxidation ×

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Now showing 1 - 3 of 3
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    The functional assessment of autotransplanted splenic tissue by its capacity to remove oxidatively modified erythrocytes
    (1997) YALÇIN, AHMET SUHA; Haklar, G.; Demirel, M.; Peker, O.; Eskitürk, A.; Işgör, A.; Söyletir, G.; Yalçin, A. S.
    Free radicals and reactive oxygen species have been implicated in the pathogenesis of a variety of hematologic diseases and erythrocyte aging. Aged erythrocytes are removed from the circulation primarily by the spleen. In this study, we aimed to determine the functional effectiveness of autotransplanted splenic tissue by its capacity to remove oxidatively modified erythrocytes from the circulation. Our experimental model in rats includes splenectomy with autotransplantation of 80% of the excised splenic tissue into the omental pouch. In this model, free radical damage was estimated by different parameters of lipid peroxidation such as carbonyl content and thiobarbituric acid reactive substances (TBARS), together with Heinz body formation. Our results have shown that splenic autotransplantation was effective in removing oxidatively modified, aged erythrocytes from the circulation.
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    Cumene hydroperoxide-induced chemiluminescence in human erythrocytes: effect of antioxidants and sulfhydryl compounds
    (1992) YALÇIN, AHMET SUHA; Yalçin, A. S.; Sabuncu, N.; Emerk, K.
    1. The time-course of cumene hydroperoxide-induced changes in lipid peroxidation, protein sulfhydryl groups and chemiluminescence intensity was determined in human erythrocytes. 2. Increase in lipid peroxidation was maximal within 60 min of incubation and was paralleled by a decrease in protein sulfhydryl groups and an increase in chemiluminescence formation. 3. A standard assay system was established to investigate the protective effects of antioxidants and scavenger compounds on cumene hydroperoxide-induced chemiluminescence formation. 4. Chain-breaking antioxidants (i.e. butylated hydroxytoluene) and sulfhydryl compounds (i.e. dithiothreitol) were able to suppress chemiluminescence formation. 5. Our results suggested that secondary free radicals, as well as sulfhydryl groups of proteins are involved in cumene hydroperoxide-induced chemiluminescence formation.
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    Evaluation of oxidant stress in chronic hemodialysis patients: use of different parameters
    (1995) YALÇIN, AHMET SUHA; Haklar, G.; Yeğenağa, I.; Yalçin, A. S.
    Patients with chronic renal failure, particularly those undergoing regular dialysis treatment (RDT) are candidates for free radical damage. It is difficult to quantitate free radicals because of their short half-lives and reactive nature. Therefore, indirect methods measuring products of lipid peroxidation and protein oxidation are preferred. The present study displays a profile of lipid peroxidation and protein oxidation parameters, which are more sensitive and specific than the widely used method measuring thiobarbituric acid reactive substances (TBARS), adapted to the plasma and erythrocyte samples of RDT patients. We have observed increased levels of plasma and erythrocyte lipid peroxidation and also demonstrated increased protein oxidation in erythrocyte membranes of RDT patients.