Person: BİNNETOĞLU, ADEM
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BİNNETOĞLU
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ADEM
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Publication Metadata only Predictive value of the neutrophil-to-lymphocyte ratio in patients with deep neck space infection secondary to acute bacterial tonsillitis(ELSEVIER IRELAND LTD, 2015) BİNNETOĞLU, ADEM; Baglam, Tekin; Binnetoglu, Adem; Yumusakhuylu, Ali Cemal; Gerin, Fethullah; Demir, Berat; Sari, MuratObjective: The aim of this study was to determine whether the neutrophil-to-lymphocyte ratio (NLR) can be used as a predictor for deep neck space infections (DNSIs) that occur as a complication of acute bacterial tonsillitis in the pediatric population. Materials and methods: We evaluated the NLR values of 180 pediatric patients diagnosed with acute bacterial tonsillitis with or without DNSI who presented to the Otolaryngology Department of Marmara University Hospital between 2010 and 2013. In cases in which DNSI was suspected, the patients underwent complete otolaryngological examination and radiological imaging including CT and MRI. NLR was calculated in all the subjects and was compared between the patients with acute bacterial tonsillitis without DNSI and those with DNSI. Results: With regard to the tonsillitis-related complications, 17 patients had peritonsillar abscess (9.4%); five, parapharyngeal abscess (2.8%); and two, retropharyngeal abscess (1.1%). The mean NLR was significantly higher in the patients of acute bacterial tonsillitis with DNSI (P < 0.05). The optimum cut-off value of NLR was determined to be 5.4. Conclusion: This study is the first to investigate the relationship between NLR and DNSI as a complication of acute bacterial tonsillitis. The results demonstrated that the NLR value could be a potential laboratory parameter for diagnosing DNSIs. (C) 2015 Elsevier Ireland Ltd. All rights reserved.Publication Open Access Association between Family History and Idiopathic Sudden Sensorineural Hearing Loss(2015-07-07) BİNNETOĞLU, ADEM; Binnetoglu, Adem; Yumusakhuylu, Ali Cemal; Demir, Berat; Baglam, Tekin; Derinsu, Ufuk; Sari, MuratPublication Metadata only Circulating calprotectin as a biomarker of laryngeal carcinoma(SPRINGER, 2017) BİNNETOĞLU, ADEM; Topuz, Muhammet Fatih; Binnetoglu, Adem; Yumusakhuylu, Ali Cemal; Sari, Murat; Baglam, Tekin; Gerin, FetullahCalprotectin is an S100 protein and marker of inflammation found in neutrophils and monocytes; S100 proteins are a family of calcium-modulated proteins. The aim of this study was to determine if the serum concentration of calprotectin is higher in patients with laryngeal carcinoma than in patients with benign laryngeal pathologies and controls. The study included 107 participants. The serum calprotectin concentration was analyzed using the calprotectin ELISA (enzyme-linked immunosorbent assay) kit (Calpo AS, Norway). EDTA-serum for analysis was collected prior to surgery from patients with laryngeal carcinoma (n = 41), those with a benign laryngeal pathology (Reinke's edema, vocal nodules, etc.) (n = 32), and healthy controls (n = 34). The median serum calprotectin concentration was significantly higher in the laryngeal carcinoma group (2179.6 mu g L-1) than in the benign laryngeal pathology group (727.84 mu g L-1) and control group (733.73 mu g L-1) (P < 0.05). The median serum calprotectin concentration in patients with advanced-stage laryngeal cancer (5854.,4 mu g L-1) was significantly higher than in those with early-stage laryngeal cancer (971.84 mu g L-1) (P < 0.05); however, there was not a significant difference in the median calprotectin concentration between the control and benign laryngeal pathology groups (P > 0.05). Furthermore, the median serum calprotectin concentration in the patients with early-stage laryngeal cancer (n = 21) (971.84 mu g L-1) was significantly higher than that in the benign laryngeal pathology and control groups (n = 64) (730.6 mu g L-1) (P < 0.05). The serum calprotectin concentration was strongly correlated with poor survival and advanced-stage laryngeal carcinoma. Malignant laryngeal cancer patients (n = 4) that died during follow-up had a higher median serum calprotectin concentration (9468.4 mu g L-1) than those that remained alive (n = 37) (857.78 mu g L-1) (P < 0.05). The serum calprotectin concentration is higher in patients with laryngeal carcinoma than in those with benign laryngeal pathologies and healthy controls. The present findings show that the serum calprotectin concentration might be used as a marker to discriminate between laryngeal carcinoma and benign laryngeal pathologies. Additional research is needed to further assess the value of this parameter as a useful tumor marker for the diagnosis, treatment, and follow-up of laryngeal carcinoma.Publication Open Access Effectiveness of Recombinant Human Growth Hormone for Pharyngocutaneous Fistula Closure(KOREAN SOC OTORHINOLARYNGOL, 2015) BİNNETOĞLU, ADEM; Kucuk, Nurten; Sari, Murat; Midi, Ahmet; Yumusakhuylu, Ali Cemal; Findik, Ozan; Binnetoglu, AdemObjectives. In laryngeal cancer, which comprises 25% of head and neck cancer, chemotherapy has come into prominence with the increase in organ-protective treatments. With such treatment, salvage surgery has increased following recurrence; the incidence of pharyngocutaneous fistula has also increased in both respiratory and digestive system surgery We investigated the effects of recombinant human growth hormone on pharyngocutaneous fistula closure in Sprague-Dawley rats, based on an increase in amino acid uptake and protein synthesis for wound healing, an increase in mitogenesis, and enhancement of collagen formation by recombinant human growth hormone. Methods. This study was experimental animal study. Forty Sprague-Dawley rats were separated into two groups, and pharyngoesophagotomy was perfouned. The pharyngoesophagotomy was sutured with vicryl in both groups. Rats in group 1 (control group) received no treatment, while those in group 2 were administered a subcutaneous injection of recombinant human growth hormone daily. On day 14, the pharynx, larynx, and upper oesophagus were excised and examined microscopically. Results. Pharyngocutaneous fistula exhibited better closure macroscopically in the recombinant human growth hormone group. There was a significant difference in collagen formation and epithelisation in the recombinant human growth hormone group compared to the control group. Conclusion. This study is believed to be the first in which the effect of recombinant human growth hormone on pharyngocutaneous fistula closure was evaluated, and the findings suggest the potential of use of growth hormone for treatment of pharyngocutaneous fistula.Publication Metadata only Is it safe to perform adenotonsillectomy in children with Down syndrome?(SPRINGER, 2016) BİNNETOĞLU, ADEM; Yumusakhuylu, Ali Cemal; Binnetoglu, Adem; Demir, Berat; Baglam, Tekin; Sari, MuratThis retrospective review aims to evaluate the postoperative morbidity and mortality of 30 patients with Down syndrome who underwent adenotonsillectomy between June 2012 and December 2015 in a tertiary referral center. Mean age was 7.8 with a range of 3-12. There were 20 (66.6 %) male and ten (33.3 %) female patients. Mean follow-up was 23 months with a range of 7-43 months. 23 (76.6 %) of 30 patients had been operated due to obstructive tonsillar and adenoid hypertrophy, whereas seven (23.3 %) of them operated for chronic recurrent infections. All of the patients had undergone adenotonsillectomy operation; one patient had also bilateral tympanostomy tube insertion. Hospital stay was noted 1.3 days in average with a range of 1-3 days. Anesthetic complications of persistent bradycardia and postextubation respiratory difficulty occurred in two (6.6) patients. Patient who had intraoperative bradycardia necessitated intensive care unit stay and pacemaker implantation during follow-up. 3 (10 %) patients had late onset hemorrhage between days 7 and 10 and required intraoperative bleeding control. We did not experience any other morbidity and mortality except the abovementioned ones. In conclusion, adenotonsillectomy in patients with Down syndrome is a worthwhile operation with certain risks and these operations should better be performed by the tertiary referral centers which have the capacity to deal with the complications.Publication Open Access Use of a Gelatin-Thrombin Hemostatic Matrix for Secondary Bleeding After Pediatric Tonsillectomy(AMER MEDICAL ASSOC, 2016-10-01) BİNNETOĞLU, ADEM; Binnetoglu, Adem; Demir, Berat; Yumusakhuylu, Ali Cemal; Baglam, Tekin; Sari, MuratIMPORTANCE Secondary posttonsillectomy bleeding associated with oozing from multiple sites or overcauterized tonsillar bed deserves special evaluation. OBJECTIVE To evaluate the use of an absorbable, flowable gelatin-thrombin hemostatic matrix (GTHM) sealant for secondary bleeding after tonsillectomy. DESIGN, SETTING, AND PARTICIPANTS This was a retrospective data analysis, with information gathered from medical records of pediatric patients with secondary posttonsillectomy bleeding treated with the GTHM between 2012 and 2016 at a referral center and a local satellite facility. Forty-two pediatric patients admitted with secondary bleeding after tonsillectomy characterized by diffuse bleeding, multiple bleeding sites, or an overcauterized tonsillar bed, were treated with GTHM. Exclusion criteria were a bleeding disorder, genetic syndrome associated with abnormal oropharyngeal anatomy, and hemorrhage from a single site. EXPOSURES GTHM was used to treat posttonsillectomy secondary bleeding. MAIN OUTCOMES AND MEASURES Patient medical records were reviewed for information relevant to this study: (1) patient history, the tonsillectomy surgical technique used, and whether there were prior bleeding episodes (and if so, methods of treatment); (2) physical examination and laboratories on presentation, operative report details, and results of treatment; (3) hospital course and whether any further bleeding episodes occurred; and (4) hospital follow-up information (range, 3-20 months). RESULTS The study population comprised 22 boys (52%) and 20 girls (48%) (a total of 42 patients), and the mean (SD) age was 7 (2.7) years (range, 4-14 years). Two patients had presented with recurrent secondary bleeding necessitating multiple operations, but the others had only 1 episode. The mean day of occurrence of bleeding was on the eighth day (range, day 7-12; median, day 10). Only 2 patients required blood transfusions: they were the same patients who underwent multiple operations for recurrent episodes of secondary bleeding. All patients except for 1 (41 of 42) were discharged without further bleeding following treatment. No adverse effects were reported. CONCLUSIONS AND RELEVANCE Results suggest that GTHM is generally simple, safe, and effective for use in the treatment of posttonsillectomy secondary bleeding types not associated with a direct vein or artery source but oozing from multiple sites and/or overcauterized tonsillar bed that cannot be stopped by traditional hemostatic methods.Publication Open Access Does Papillary Carcinoma of Thyroglossal Duct Cyst Develop De Novo?(HINDAWI LTD, 2015) BİNNETOĞLU, ADEM; Baglam, Tekin; Binnetoglu, Adem; Yumusakhuylu, Ali Cemal; Demir, Berat; Askan, Gokce; Sari, MuratBackround. Thyroglossal duct cyst (TDC) is a developmental abnormality of the thyroid gland. Due to embryological remnants of thyroid tissue located in the TDC, the same malignant tumors that develop in the thyroid gland can also develop in the TDC. Methods. We present the unique case of a 39-year-old female with simultaneous de novo papillary carcinoma in a TDC and the thyroid gland. Results. With the suspicion of simultaneous papillary carcinoma in the TDC and the thyroid gland, Sistrunk procedure with total thyroidectomy and central neck exploration was performed. Conclusion. The clinician should have a high index of suspicion upon encountering papillary carcinoma of the TDC to differentiate de novo papillary carcinoma in the TDC fromthose originating fromthe thyroid gland, because papillary carcinoma in TDCmay originate froman occult thyroid papillary carcinoma.Publication Open Access A Rare Variation of Inferior Laryngeal Nerve: Nonrecurrent Laryngeal Nerve(GALENOS YAYINCILIK, 2015-05-11) BİNNETOĞLU, ADEM; Binnetoglu, Adem; Yumusakhuylu, Ali Cemal; Topuz, Muhammet Fatih; Demir, Berat; Baglam, Tekin; Sari, MuratA nonrecurrent laryngeal nerve variant of the inferior laryngeal nerve is very rarely seen, and surgeons should keep it in mind during thyroid surgery. Preoperative findings, like situs invertus and dysphagia lusoria, may be suggestive of a nonrecurrent laryngeal nerve. However, these findings always have not to be together with nonrecurrent laryngeal nerve, like our case.Publication Metadata only Comparison of pharyngocutaneous fistula closure with and without bacterial cellulose in a rat model(ELSEVIER SCI LTD, 2018) BİNNETOĞLU, ADEM; Demir, Berat; Sari, Murat; Binnetoglu, Adem; Yumusakhuylu, Ali Cemal; Filinte, Deniz; Tekin, Ishak Ozel; Baglam, Tekin; Batman, Abdullah CaglarObjective: The present study aimed to compare the effects of bacterial cellulose used for closure of pharyngocutaneous fistulae, a complication of total laryngectomy, with those of primary sutures in a rat model. Methods: Thirty female Sprague-Dawley underwent experimental pharyngoesophagotomy and were grouped depending on the material used for pharyngocutaneous fistula closure: group I, which received primary sutures alone, group II, which received bacterial cellulose alone; and group III, which received both. After 7 days, the rats were sacrificed. Pharyngocutaneous fistula development was assessed, the gross wound was inspected, and histological examination was conducted. Results: Pharyngocutaneous fistulae developed in 12 rats (41%) in all: 6 from group I (21%), 4 from group II (14%) and 2 from group III (7%). Conclusion: Fibroblast density and inflammatory cell infiltration were significantly greater in group III than group I. We concluded that bacterial cellulose may be useful for pharyngocutaneous fistula closure. (C) 2017 Elsevier B.V. All rights reserved.