Person: FAK, ALİ SERDAR
Loading...
Email Address
Birth Date
Research Projects
Organizational Units
Job Title
Last Name
FAK
First Name
ALİ SERDAR
Name
5 results
Search Results
Now showing 1 - 5 of 5
Publication Metadata only Expert panel on cost analysis of atrial fibrillation(TURKISH SOC CARDIOLOGY, 2013) FAK, ALİ SERDAR; Fak, Ali Serdar; Kucukoglu, M. Serdar; Fak, Nazire Afsar; Demir, Mesut; Agir, Aysen A.; Demirtas, Mustafa; Kose, Sedat; Ozdemir, MuratObjective: To estimate total cost of atrial fibrillation (AF) management concerning acute coronary syndrome, heart failure, stroke and drug related adverse events with respect to clinical practice and available guidelines. Methods: This cost analysis study was based on identification of total costs related to management of acute coronary syndrome, heart failure, stroke and the drug related adverse events in patients with AF based on standardized questionnaire forms filled by experts according to their daily clinical practice and also to ACCF/AHA/ESC guidelines. Total cost included cost items related to treatment, healthcare resources utilization, and diagnostic test and consultations. Results: The yearly cost of acute coronary syndrome per patient was 5.478.43 TL according to expert's view reflecting real clinical practice whereas it was 11.319.44 TL when calculation was based on recommendations in the guidelines. The average total cost of heart failure was 4.523.74 TL according to expert's view whereas it was 2.925.86 TL based on guidelines. The average total cost of stroke was 5.719.25 TL according to expert's view but 7.931.18 TL based on guidelines. Among drug related adverse events, only those related to cardiac adverse events were estimated to be higher according to expert view as compared to guideline recommendations (288.65 vs. 150.99 TL). Conclusions: Reflecting the treatment algorithms in the management of AF and related adverse events, our findings seem to emphasize the extra burden on health economics posed by patients suffering from the uncontrolled disease. (Anadolu Kardiyol Derg 2013; 13: 26-38)Publication Open Access Polymorphisms of the angiotensin-converting enzyme and angiotensinogen gene in patients with atrial fibrillation(SAGE PUBLICATIONS LTD, 2011-12) FAK, ALİ SERDAR; Topal, Nurdan Papila; Ozben, Beste; Hancer, Veysel Sabri; Tanrikulu, Azra Meryem; Diz-Kucukkaya, Reyhan; Fak, Ali Serdar; Basaran, Yelda; Yesildag, OsmanActivation of the renin-angiotensin system (RAS) is associated with atrial fibrillation (AF). The aim of this study was to investigate the relation between AF and polymorphisms in RAS. One hundred and fifty patients with AF, 100 patients with no documented episode of AF and 100 healthy subjects were consecutively recruited into the study. The angiotensin-converting enzyme (ACE) insertion/deletion (I/D) polymorphism, and the M235T, A-20C, and G-6A polymorphisms of the angiotensinogen gene were genotyped. Patients with AF had significantly lower frequency of II genotype of ACE I/D and higher frequency of angiotensinogen M235T polymorphism T allele and TT genotype and G-6A polymorphism G allele and GG genotype compared with the controls. AF patients had significantly larger left atrium, higher left ventricular mass index (LVMI) and higher frequency of significant valvular pathology. ACE I/D polymorphism II genotype, angiotensinogen M235T polymorphism TT genotype and G allele and GG genotype of angiotensinogen G-6A polymorphism were still independently associated with AF when adjusted for left atrium, LVMI and presence of significant valvular pathology. Genetic predisposition might be underlying the prevalence of acquired AF. Patients with a specific genetic variation in the RAS genes may be more liable to develop AF.Publication Open Access Yeni Bir Yaklaşımla Genç Bireylerde Kalp Sağlığı Takibi için Web ve Mobil Uygulama Geliştirilmesi(2019-11-01) FAK, ALİ SERDAR; ZEHRA AYSUN ALTIKARDEŞ;Mensur BAJGORA;Ufuk SARIKAYA;BUKET DOĞAN;ALİ SERDAR FAKKardiyovasküler hastalık riskini tetikleyen hipertansiyon, obezite, diyabet gibi önlenebilir hastalıkların ve risk faktörülerinin sıklığı ülkemizdekigenç bireylerde hızla artmaktadır. Bu hastalıkların kontrollü bir şekilde takip edilebilmesi ve önlenebilmesi için Marmara Üniversitesiöğrencilerinin demografik ve sağlık verilerinin kayıt altına alınmasını ve izlenmesini sağlayan web ve mobil uygulamanın geliştirilmesisağlanmıştır. Böylece, Framingham risk skoruna göre öğrencilerin 10 yıllık kardiyovasküler risklerinin hesaplanarak görüntülendiğive kişiye özel hale getirilmiş tıbbi önerilerin e-posta yoluyla bildirildiği bir web platformu PHP ve MySQL kullanılarak oluşturulmuştur.Öğrencilerin ilerleyen zamandaki kardiyovasküler hastalık risklerinin takip edilebildiği bu platform, yüksek risk grubunda olan bireylerinrisk seviyelerinin normale indirilebilmesi için farkındalıklarını arttıran bir işlevselliğe sahiptir. Hazırlanan web platformunun desteklenmesiiçin, Marmara Üniversitesi öğrencilerinin kendi sağlık durumlarını takip edebilecekleri, kalp sağlığı konusunda bilinçlendirici bildirimlerledestekleneceği ve yaşam kalitelerini arttırabilmeleri için bir standart oluşturulmasına yardımcı olacak “Sağlıklı Kalpler” adındaAndroid ve iOS platformlarında kullanılmak üzere bir mobil uygulama geliştirilmiştir. Bu uygulama içerisinde adım sayar, egzersiz ekleme,listeleme, sağlıklı beslenme ve güncel sağlık durumunu izleme gibi fonksiyonlar bulunmaktadır.Publication Metadata only Investigation of the Association Between Dopamine D1 Receptor Gene Polymorphisms and Essential Hypertension in a Group of Turkish Subjects(INFORMA HEALTHCARE, 2011) FAK, ALİ SERDAR; Orun, Oya; Nacar, Cevdet; Cabadak, Hulya; Tiber, Pinar Mega; Dogan, Yuksel; Guneysel, Ozlem; Fak, Ali Serdar; Kan, BekiDopamine has been shown to influence blood pressure by regulating renal sodium excretion through direct interaction with the dopamine receptors, especially with the Dopamine D1 receptor (DRD1). To better understand the role of polymorphisms in those effects, we investigated the association between two polymorphic sites in the DRD1 promoter region (A-48G, G-94A) and essential hypertension in the Turkish population. The DRD1 variants were genotyped by restriction fragment length polymorphism (RFLP) analysis. A total of 205 unrelated individuals were enrolled in the study. We found that genotype distributions and allele frequencies of the control and hypertensive subjects were very similar and did not show any significant difference with respect to blood pressure (BP) and hypertension. Contribution of the gene variances in BP or hypertension by sex differences and dependence on body mass index (BMI) were also evaluated. Distribution of genotypes and allele frequencies were found to be in line with previous reports. However, increments detected in hypertensive subjects were far from being statistically significant.Publication Metadata only The Role of G Protein beta 3 Subunit Polymorphisms C825T, C1429T, and G5177A in Turkish Subjects with Essential Hypertension(TAYLOR & FRANCIS INC, 2011) FAK, ALİ SERDAR; Cabadak, Hulya; Orun, Oya; Nacar, Cevdet; Dogan, Yuksel; Guneysel, Ozlem; Fak, Ali Serdar; Kan, BekiHypertension is a multifactorial disorder that constitutes a major risk factor for the cardiovascular system. Heterotrimeric G-proteins, which couple receptors for diverse extracellular enzymes or ion channels, are correlated with disease mechanisms. Several studies have demonstrated an association between G protein polymorphisms and essential hypertension in some populations, although contradictive results also exist. In this study, we have investigated the potential role of the C825T, C1429T, and G5177A polymorphisms of the beta 3 subunit of G-proteins in essential hypertension in a group of Turkish subjects. Genomic DNA from 106 normotensive individuals (117.4 +/- 13.1, 75.2 +/- 10.5; systolic blood pressure (SBP) and diastolic blood pressure (DBP) levels, respectively) and 101 hypertensive subjects (152.3 +/- 18.0, 92.5 +/- 11.6; SBP and DBP levels, respectively) were studied by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and direct sequencing methods for these polymorphisms. Allele frequencies of the polymorphisms were consistent with Hardy Weinberg equilibrium, except for the C825T polymorphism (chi(2) = 7.8). The frequencies of the 825T and 1429T variants were higher in hypertensive subjects compared to those of controls. Differences between hypertensives and controls were not statistically significant, though difference was very close to significance for C825T (p = 0.056 and 0.099 for 825T and 1429T, respectively). T allele frequency in overall population showed significant association with hypertension for C825T (0.0134). The prevalence of the 5177A-variant was very low and all subjects carrying it were heterozygotes in both groups.